Searched for: author%3A%22Verheijen%2C+J.H.%22
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Slomp, J. (author), Koopman, J.L. (author), Quax, P.H.A. (author), de Bart, A.C.W. (author), Hennius, B.C. (author), Nieuwenbroek, N.M.E. (author), Verheijen, J.H. (author), TNO Preventie en gezondheid (author)
abstract
article 1996
document
Quax, P.H.A. (author), Koolwijk, P. (author), Verheijen, J.H. (author), van Hinsbergh, V.W.M. (author), TNO Preventie en gezondheid (author)
bookPart 1996
document
Wijnberg, M.J. (author), Nieuwenbroek, N.M.E. (author), Ouax, P.H.A. (author), Verheijen, J.H. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
The plasminogen activation system is known to be involved in several cell migration processes. A role for plasminogen activators in smooth muscle cell migration after vascular injury has been suggested from several animal studies. However, not much is known about their involvement in human vascular remodelling. In this study, the role of the...
article 1996
document
Ronday, H.K. (author), Smits, H.H. (author), van Muijen, G.N.P. (author), Pruszczynski, M.S.M. (author), Dolhain, R.J.E.M. (author), van Langelaan, E.J. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
Proteolytic joint destruction in inflammatory and non-inflammatory arthropathy is believed to be mediated, at least in part, by the plasminogen activation (PA) system. To further investigate possible involvement of the PA system, we quantified immunoreactive urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA),...
article 1996
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Ronday, H.K. (author), Smits, H.H. (author), Quax, P.H.A. (author), van der Pluijm, G. (author), Löwik, C.W.G.M. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
article 1995
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de Bart, A.C.W. (author), Quax, P.H.A. (author), Löwik, C.W.G.M. (author), Verheijen, J.H. (author), TNO Preventie en Gezondheid (author)
Plasmin-mediated extracellular proteolysis has been implicated in the degradation of bone in normal and pathological conditions. Normal and malignant osteoblasts can produce both tissue-type plasminogen activator (t- PA) and urokinase-type plasminogen activator (u-PA). We have used the osteosarcoma cell line MG63 to address the question of...
article 1995
document
Gaubius Instituut TNO (author), Bakker, A.H.F. (author), Weening-Verhoeff, E.J.D. (author), Verheijen, J.H. (author)
To describe the role of the lysyl binding site in the interaction of tissue-type plasminogen activator (t-PA, FGK1K2P) with a forming fibrin clot, we performed binding experiments with domain deletion mutants GK1K2P, K2P, and the corresponding point mutants lacking the lysyl binding site in the absence and the presence of ε-amino caproic acid ...
article 1995
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Padro, T. (author), Quax, P.H.A. (author), van den Hoogen, C.M. (author), Roholl, P. (author), Verheijen, J.H. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Plasminogen activator (PA) and PA inhibitor (PAI) antigen, activity, and mRNA were analyzed in the three layers of rat aorta, and the effect of endotoxin on PA and PAI was studied. All PA activity in aorta was identified as tissue-type PA (TPA) activity; no urokinase-type PA was detected. In the tunica adventitia TPA activity, TPA antigen, and...
article 1994
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Ganesh, S. (author), Sier, C.F.M. (author), Griffioen, G. (author), Vloedgraven, H.J.M. (author), de Boer, A. (author), Welvaart, K. (author), van de Velde, C.J.H. (author), van Krieken, J.H.J.M. (author), Verheijen, J.H. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Human colorectal carcinogenesis has been shown previously to be associated with impressive changes in the tissue levels of plasminogen activators and their inhibitors, exemplified by an increase in the urokinase-type plasminogen activator (u-PA) and the inhibitors PAI-1 and PAI-2, and a decrease in tissue-type plasminogen activator (t-PA). In...
article 1994
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van Hinsbergh, V.W.M. (author), Quax, P.H.A. (author), Koolwijk, P. (author), Verheijen, J.H. (author), TNO Preventie en Gezondheid (author)
Abstract
article 1994
document
van Muijen, G.N.P. (author), de Vries, T.J. (author), Danen, E.H.J. (author), Quax, P. (author), Verheijen, J.H. (author), Ruiter, D.J. (author), TNO Preventie en Gezondheid (author)
In the pathogenesis qf human tumors the capacity of tumor cells to form metastases is one of the most crucial events. Ther^ore, the unravelling of molecular mechanisms involved in the process of metastasis is very important. Next to a great number of other factors, extracellular proteases and adhesion molecules of the integrin superfamily...
bookPart 1994
document
Gaubius Instituut TNO (author), Bakker, A.H.F. (author), van der Greef, W. (author), Rehberg, E.F. (author), Marotti, K.R. (author), Verheijen, J.H. (author)
Despite the high overall similarity in primary structure between kringle one (K1) and kringle two (K2) of tissue-type plasminogen activator (t-PA) there exists an enormous functional difference. It is thought that, in contrast to K1, K2 mediates lysine binding and fibrin binding and is involved in stimulation of plasminogen activation by fibrin...
article 1993
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Emeis, J.J. (author), Verheijen, J.H. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Chemicals/CAS: Recombinant Proteins; Tissue Plasminogen Activator, EC 3.4.21.68
article 1992
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Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Kluft, C. (author), Verheijen, J.H. (author)
Procedures of blood collection and handling are different for the various variables in haemostasis and tend to change gradually with progress in knowledge and methods. The Working Party has gathered background information about procedures and discussed minimal requirements specifically for t-PA and PAI-1 assessment. The general procedure from...
article 1992
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Weening-Verhoeff, E.J.D. (author), Quax, P.H.A. (author), van Leeuwen, R.T.J. (author), Rehberg, E.F. (author), Marotti, K.R. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
article 1990
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Quax, P.H.A. (author), van Leeuwen, R.T.J. (author), Verspaget, H.W. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
In 22 human tumor cell lines the regulation of production of plasminogen activators urokinase (u-PA) and tissue-type (u-PA) and their inhibitors PAI-1 and PAI-2 was studied. These four components may determine the net plasminogen activator activity, which is often associated with tumor development and metastatic processes. The amount of specific...
article 1990
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Gaubius Instituut TNO (author), Quax, P.H.A. (author), van den Hoogen, M. (author), Verheijen, J.H. (author), Padro, T. (author), Zeheb, R. (author), Gelehrter, T.D. (author), van Berkel, T.J.C. (author), Kuiper, J. (author), Emeis, J.J. (author)
The tissue-specific distribution of tissue-type and urokinase-type plasminogen activator (t-PA and u-PA) and their inhibitor type 1 (PAI-1) was analyzed at mRNA level in five major rat organ tissues. t-PA mRNA was detected in lung, kidney, heart, and liver. u-PA mRNA was detected in kidney and lung. Presence of PA mRNA correlated with the...
article 1990
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Gezondheidsorganisatie TNO Gaubius instituut TNO (author), de Bruin, P.A.F. (author), Verspaget, H.W. (author), Griffioen, g. (author), Verheijen, J.H. (author), Dooijewaard, G. (author), Lamers, C.B.H.W. (author)
In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies of colonic and gastric...
article 1989
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Verheijen, J.H. (author), Gaubius Instituut TNO (author)
At the beginning of this century the first experiments on cell and tissue culturing were performed. In this early period of culturing techniques, cells and tissues were frequently cultured on blood or plasma clots. It was observed that culturing of some tissues led to lysis of the clot, while other tissues had no effect on clot consistency. In a...
bookPart 1988
document
Verheijen, J.H. (author), Visse, R. (author), Wijnen, T.J. (author), Gaubius Instituut TNO (author)
Using 1.2kb 3'-terminal Pst-I fragment of a full length tissue-type plasminogen activator (t-PA) cDNA clone (ptPA-8FL) and a set of rodent human somatic cell hydrids, the corresponding human gene PLAT was localized on chromosome 8. Chemicals/CAS: plasminogen activator, 9039-53-6; DNA Restriction Enzymes, EC 3.1.21; DNA, 9007-49-2; Genetic...
article 1986
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