Searched for: author%3A%22Verheijen%2C+J.H.%22
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Hanemaaijer, R. (author), Verheijen, J.H. (author), Maguire, T.M. (author), Visser, H. (author), Toet, K. (author), McDermott, E. (author), O'Higgins, N. (author), Duffy, M.J. (author), Gaubius Instituut TNO (author)
Matrix metalloproteinases (MMP) types 2 and 9 (also known as gelatinase A and B) are thought to be causally involved in cancer invasion and metastasis. In normal as well as in malignant tissue, both these MMPs occur in multiple forms such as inactive precursors, active enzymes and enzyme- inhibitor complexes. Using newly developed quantitative...
article 2000
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van der Laan, W.H. (author), Pap, T. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), TeKoppele, J.M. (author), Breedveld, F.C. (author), Gay, R.E. (author), Gay, S. (author), Huizinga, T.W.J. (author), Verheijen, J.H. (author), Quax, P.H.A. (author)
article 2000
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de Smet, B.J.G.L. (author), de Kleijn, D. (author), Hanemaaijer, R. (author), Verheijen, J.H. (author), Robertus, L. (author), van der Helm, Y.J.M. (author), Borst, C. (author), Post, M.J. (author), Gaubius Instituut TNO (author)
Background - Arterial remodeling after balloon angioplasty has been recognized as a major determinant of restenosis. Perturbation of collagen metabolism might be important. After balloon injury, matrix metalloproteinase (MMP) expression is upregulated. We investigated the effect of Batimastat, a nonspecific MMP inhibitor, on late lumen loss,...
article 2000
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Gaubius Instituut TNO (author), van der Laan, W.H. (author), Molenaar, E.T. (author), Verheijen, J.H. (author), Breedveld, F.C. (author), Dijkmans, B.A.C. (author), te Koppele, J.M. (author)
article 2000
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Wijnberg, M.J. (author), Slomp, J. (author), Verheijen, J.H. (author), Gaubius instituut TNO (author)
In this study we examined the localization of the plasminogen activation system and the matrix metalloproteinases in normal human arteries, arteries with diffuse intimal thickenings and atherosclerotic arteries. We found that MMP-1, MMP-2, MMP-3, TIMP-1 and TIMP-2 did not stain differently in normal arteries, arteries with intimal thickening and...
article 1999
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van der Laan, W.H. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), TeKoppele, J.M. (author), Huizinga, T.W.J. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Quax, P.H.A. (author), Gaubius Instituut TNO (author)
bookPart 1999
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Gaubius Instituut TNO (author), van der Laan, W.H. (author), Ronday, H.K. (author), Grimbergen, J.M. (author), Huisman, L.G.M. (author), Breedveld, F.C. (author), te Koppele, J.M. (author), Huizinga, T.W.J. (author), Quax, P.H.A. (author), Verheijen, J.H. (author)
article 1999
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Ronday, H.K. (author), TeKoppele, J.M. (author), Greenwald, R.A. (author), Moak, S.A. (author), de Roos, J.A.D.M. (author), Dijkmans, B.A.C. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
The plasminogen activation system is one of the enzyme systems held responsible for bone and cartilage degradation in rheumatoid arthritis (RA). In this study, we evaluated the effect of tranexamic acid (TEA), an inhibitor of plasminogen activation, on urinary collagen cross-link excretion and radiological joint damage in rat adjuvant arthritis ...
article 1998
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Hanemaaijer, R. (author), Visser, H. (author), Konttinen, Y.T. (author), Koolwijk, P. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
Here we describe a new principle for accessing the activity of the different members of the human matrix-metalloproteinases (MMPs) by a colorimetric assay. Using protein engineering, a modified pro-urokinase was made in which the activation sequence, normally recognized by plasmin (ProArgPheLys ↓ IlelleGlyGly), was replaced by a sequence that is...
article 1998
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Quax, P.H.A. (author), Grimbergen, J.M. (author), Lansink, M. (author), Bakker, A.H.F. (author), Blatter, M.C. (author), Belin, D. (author), van Hinsbergh, V.W.M. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
Urokinase-type plasminogen activator (UPA), particularly when bound to its receptor (UPAR), is thought to play a major role in local proteolytic processes, thus facilitating cell migration as may occur during angiogenesis, neointima and atherosclerotic plaque formation, and tumor cell invasion. To facilitate understanding of the need and...
article 1998
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Hanemaaijer, R. (author), Visser, H. (author), Duffy, J. (author), Verspaget, H.W. (author), Verheijen, J.H. (author), Maguire, T. (author), Gaubius Instituut TNO (author)
Matrix metalloproteinases (MMPs) play an important role in many pathological processes. However, MMP activities are difficult to determine since no simple specific and/or chromogenic substrates exist. Therefore, we have developed a novel MMP activity assay using a modified urokinase as a substrate. In this urokinase, as obtained by protein...
article 1998
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van der Laan, W.H. (author), Grimbergen, J.M. (author), Verheijen, J.H. (author), Pha, Q. (author), Gaubius Instituut TNO (author)
In rheumatoid arthritis (RA), irreversible joint damage is the result of degradation of articular structures such as cartilage, bone and tendons. The plasminogen activator (PA) system has been shown to be involved in the proteolytic degradation of cartilage matrix by rheumatoid synovial fibroblasts in vitro. To study the possibilities for...
article 1998
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Wijnberg, M.J. (author), Quax, P.H.A. (author), Nieuwenbroek, N.M.E. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
The plasminogen activation system is thought to be important in cell migration processes. A role for this system during smooth muscle cell migration after vascular injury has been suggested from several animal studies. However, not much is known about its involvement in human vascular remodelling. We studied the involvement of the plasminogen...
article 1997
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Gaubius Instituut TNO (author), Verheijen, J.H. (author), Nieuwenbroek, N.M.E. (author), Beekman, B. (author), Hanemaaijer, R. (author), Verspaget, H.W. (author), Ronday, K.H. (author), Bakker, A.H.F. (author)
We describe a new principle for assessment of the activity of proteolytic enzymes of all classes and show the application of this principle for the quantitative assay of bacterial collagenase and human matrix metalloproteinases (MMPs). Central to this new principle is the presence of a proenzyme that can be activated into an active enzyme by a...
article 1997
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Mulder, M. (author), Kohnert, U. (author), Fischer, S. (author), van Hinsbergh, V.W.M. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
The Escherichia coli-expressed recombinant plasminogen activator (r-PA) comprising the kringle 2 and protease domains of human tissue-type plasminogen activator (t-PA) has a four-fold longer half-life time in the circulation than t-PA, possibly resulting in an increased opportunity for r-PA to interact with the endothelial lining. In the present...
article 1997
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Gaubius Instituut TNO (author), Ganesh, S. (author), Sier, C.F.M. (author), Heerding, M.M. (author), van Krieken, J.H.J.M. (author), Griffioen, G. (author), Welvaart, K. (author), van de Velde, C.J.H. (author), Verheijen, J.H. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author)
Despite the advances in pre-, peri- andpost-operative medical care of colorectal carcinoma patients, the prognosis has improved only marginally over recent decades. Thus, additional prognostic indicators would be of great clinical value to select patients for adjuvant therapy. In previous studies we found that colorectal carcinomas have a marked...
article 1997
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Koopman, J.L. (author), Slomp, J. (author), de Bart, A.C.W. (author), Quax, P.H.A. (author), Verheijen, J.H. (author), TNO Preventie en gezondheid (author)
article 1996
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de Vries, T.J. (author), Verheijen, J.H. (author), de Bart, A.C.W. (author), Weidle, U.H. (author), Ruiter, D.J. (author), van Muijen, G.N.P. (author), Gaubius Instituut TNO (author)
We recently found that the proteins of the proteolytic system of plasminogen activation emerge in late stages of melanocytic tumor progression. A large body of evidence suggests a role for two proteins, the low-density lipoprotein receptor-related protein (LRP)/α2-macroglobulin receptor and its receptor-associated protein (RAP), in the...
article 1996
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Wijnberg, M.J. (author), Nieuwenbroek, N.M.E. (author), Slomp, J. (author), Quax, P.H.A. (author), Verheijen, J.H. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
The objective of this study was to investigate the role of the plasminogen activation system in the migration of human vascular smooth muscle cells in vitro. After wounding of confluent human smooth muscle cell cultures by stripping cells from their extracellular matrix, cells start to migrate from the wounded edge into the denuded area....
article 1996
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Ronday, H.K. (author), Breedveld, F.C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
article 1996
Searched for: author%3A%22Verheijen%2C+J.H.%22
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