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Keuken, M.P. (author), Moerman, M. (author), Voogt, M. (author), Zandveld, P. (author), Verhagen, H. (author), Stelwagen, U. (author), de Jonge, D. (author)In this study, NOx and particle number concentration (PNC) at an urban background and a traffic location were measured in the city of Amsterdam (the Netherlands). Modelled and measured contributions to NOx and PNC at the traffic location were used to derive real-world PN emission factors for average urban road traffic. The results for NOx were...article 2016
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Klok, L. (author), Zwart, S. (author), Verhagen, H. (author), Mauri, E. (author)Thermal infrared high resolution satellite images from Landsat sensors were used to spatially quantify the surface heat island (SHI) of Rotterdam in the Netherlands. Based on surface temperature maps retrieved on 15 summer days since 1984, the average surface temperature of each district and neighbourhood within the city was compared to the...article 2012
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Verhagen, H. (author), Andersen, R. (author), Antoine, J.-M. (author), Finglas, P. (author), Hoekstra, J. (author), Kardinaal, A. (author), Nordmann, H. (author), Pekcan, G. (author), Pentieva, K. (author), Sanders, T.A. (author), van den Berg, H. (author), van Kranen, H. (author), Chiodini, A. (author)The respective examples, described in this paper, illustrate how the BRAFO-tiered approach, on benefit-risk assessment, can be tested on a wide range of case studies. Various results were provided, ranging from a quick stop as the result of non-genuine benefit-risk questions to continuation through the tiers into deterministic/probabilistic...article 2012
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- Henzing, B. (author), Moerman, M.M. (author), Verhagen, H. (author), Schaap, M. (author), de Leeuw, G. (author), TNO Bouw en Ondergrond (author) conference paper 2008
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TNO Kwaliteit van Leven (author), Klein, E. (author), Maathuis, E. (author), Wever, C. (author), van der Greft, A. (author), Tas, W. (author), Beekman, V. (author), Gilissen, L. (author), van Gorcom, R. (author), Jansman, A. (author), Kardinaal, A. (author), te Koppele, J. (author), Schenk, E. (author), van der Sluis, A. (author), Teeuw, J. (author), Verhagen, H. (author), van Zandvoort, C. (author), Zondervan, C. (author)ZonMw heeft samen met Wageningen UR, TNO en RIVM een programmeringsstudie over voeding en gezondheid uitgebracht. De studie doet onder meer aanbevelingen voor het werken aan preventie van chronische ziekten (te beginnen bij kinderen), de verbetering van de kwaliteit van leven (te beginnen bij de doelgroep ouderen en patiënten) en het...book 2007
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TNO Bouw en Ondergrond (author), Duyzer, J. (author), Hollander, K. (author), Voogt, M. (author), Verhagen, H. (author), Weststrate, H. (author)The factors used to estimate emissions of sea going ships to air (so called emission factors) are based upon critical evaluation of the literature. Current estimates of emission factors of sea going ships are based upon a limited number of laboratory experiments and information on fuel usage and engine power. Especially emissions of nitrogen...report 2006
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Vermeulen, M. (author), Zwanenburg, B. (author), Chittenden, G.J.F. (author), Verhagen, H. (author)Twelve mercapturic acids derived from saturated and unsaturated aliphatic and aromatic isothiocyanates were synthesised, by adding isothiocyanate to a solution of N-acetyl-L-cysteine and sodium bicarbonate, in a typical yield of 77%. Isothiocyanates were synthesised first by adding the corresponding alkyl bromide to phthalimide potassium salt....article 2003
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- Krul, C.A.M. (author), Luiten-Schuitema, A. (author), Baan, R. (author), Verhagen, H. (author), Havenaar, R. (author) article 2001
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Krul, C.A.M. (author), Luiten-Schuite, A. (author), Tenfelde, A. (author), van Ommen, B. (author), Verhagen, H. (author), Havenaar, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)An in vitro gastrointestinal model, which simulates the conditions in the human digestive tract, was used to determine potential antimutagenic activity of extracts of black tea and green tea. In this paper, results are presented on the availability for absorption of potential antimutagenic compounds present in tea and on the influence of the...article 2001
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- Krul, C.A.M. (author), Luiten-Schuite, A. (author), Tenfelde, A. (author), van Ommen, B. (author), Verhagen, H. (author), Havenaar, R. (author), TNO Voeding (author) article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Verhagen, H. (author), Hageman, G.J. (author), Rauma, A.L. (author), de Versluis-Haan, G. (author), van Herwijnen, M.H.M. (author), de Groot, J. (author), Törrönen, R. (author), Mykkänen, H. (author)Allium vegetables (onions, leeks, chives) and in particular garlic have been claimed to have health-promoting potential. This study was conducted to get insight into the perspectives for monitoring the intake of garlic by a biomarker approach. Chemically, the bimarker results from exposure to gamma-glutamyl-S-allyl-L-cysteine, which is first...article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Crews, H. (author), Alink, G. (author), Andersen, R. (author), Braesco, V. (author), Holst, B. (author), Maiani, G. (author), Ovesen, L. (author), Scotter, M. (author), Solfrizzo, M. (author), van den Berg, R. (author), Verhagen, H. (author), Williamson, G. (author)In this review many examples are given of the complexities involved in using some biomarkers in relation to assessing the effects of dietary exposure, when there is frequently a need to determine changes following long-term low level exposure to dietary components. These range from understanding why the biomarker might be valuable and how best...article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Branca, F. (author), Hanley, A.B. (author), Pool-Zobel, B. (author), Verhagen, H. (author)Biomarkers have considerable potential in aiding the understanding of the relationship between diet and disease or health. However, to assess the role, relevance and importance of biomarkers on a case by case basis it is essential to understand and prioritise the principal diet and health issues. In the majority of cases, dietary compounds are...article 2001
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- van Loon, L.J.C. (author), Saris, W.H.M. (author), Verhagen, H. (author), Wagenmakers, A.J.M. (author) article 2000
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Krul, C.A.M. (author), Luiten-Schuite, A. (author), Baan, R. (author), Verhagen, H. (author), Mohn, G. (author), Feron, V. (author), Havenaar, R. (author)The TNO gastro-Intestinal tract Model (TIM) is a dynamic computer-controlled in vitro system that mimics the human physiological conditions in the stomach and small intestine. In the current TIM physiological parameters such as pH, temperature, peristaltic movements, secretion of digestion enzymes, bile and pancreatic juices, and absorption of...article 2000
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van Poppel, G. (author), Verhoeven, D.T.H. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This paper first gives an overview of the epidemiological data concerning the cancer-preventive effect of brassica vegetables, including cabbages, kale, broccoli, Brussels sprouts, and cauliflower. A protective effect of brassicas against cancer may be plausible due to their relatively high content of glucosinolates. Certain hydrolysis products...article 2000
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- van Loon, L.J.C. (author), van Rooijen, J.J.M. (author), Niesen, B. (author), Verhagen, H. (author), Saris, W.H.M. (author), Wagenmakers, A.J.M. (author) article 2000
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van Loon, L.J.C. (author), Kruijshoop, M. (author), Verhagen, H. (author), Saris, W.H.M. (author), Wagenmakers, A.J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)To optimize the postexercise insulin response and to increase plasma amino acid availability, we studied postexercise insulin levels after the ingestion of carbohydrate and wheat protein hydrolysate with and without free leucine and phenylalanine. After an overnight fast, eight male cyclists visited our laboratory on five occasions, during which...article 2000
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Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Schuurman, C.R.W.C. (author), Verhagen, H. (author), van den Berg, H. (author), Kok, F.J. (author), van Poppel, G. (author), TNO Voeding (author)Observational epidemiologic studies have shown that a high consumption of fruits and vegetables is associated with a decreased risk of chronic diseases. Little is known about the bioavailability of constituents from vegetables and fruits and the effect of these constituents on markers for disease risk. Currently, the recommendation is to...article 2000
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Botterweck, A.A.M. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Kleinjans, J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Both carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The association between dietary intake of BHA and BHT and stomach cancer risk was investigated in the Netherlands Cohort Study (NLCS) that started in 1986 among 120,852 men and...article 2000