Searched for: author%3A%22Vanwersch%2C+R.A.P.%22
(1 - 20 of 20)
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Verhave, P.S. (author), Jongsma, M.J. (author), van den Berg, R.M. (author), Vanwersch, R.A.P. (author), Smit, A.B. (author), Philippens, I.H.C.H.M. (author)
The present study evaluates neuroprotection in a marmoset MPTP (1-methyl-1,2,3,6-tetrahydropyridine) model representing early Parkinson's disease (PD). The anti-glutamatergic compound riluzole is used as a model compound for neuroprotection. The compound is one of the few protective compounds used in the clinic for a neurodegenerative disorder....
article 2012
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Verhave, P.S. (author), Jongsma, M.J. (author), van den Berg, R.M. (author), Vis, J.C. (author), Vanwersch, R.A.P. (author), Smit, A.B. (author), van Someren, E.J.W. (author), Philippens, I.H.C.H.M. (author)
Study Objectives: Sleep problems are a common phenomenon in most neurological and psychiatric diseases. In Parkinson disease (PD), for instance, sleep problems may be the most common and burdensome non-motor symptoms in addition to the well-described classical motor symptoms. Since sleep disturbances generally become apparent in the disease...
article 2011
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Verhave, P.S. (author), Vanwersch, R.A.P. (author), Helden, H.P.M. (author), Smit, A.B. (author), Philippens, I.H.C.H.M. (author), TNO Defensie en Veiligheid (author)
The validity of the common marmoset (Callithrix jacchus) as a model for human disease depends on the development of parameters with clinical relevance. We tested the effect of treatment with MPTP in two newly developed non-invasive motor behavioral paradigms in the context of Parkinson's disease. The "Tower" was designed to quantify the marmoset...
article 2009
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TNO Defensie en Veiligheid (author), van Vliet, S.A.M. (author), Vanwersch, R.A.P. (author), Jongsma, M.J. (author), Olivier, B. (author), Philippens, I.H.C.H.M. (author)
Current therapies for Parkinson's disease (PD) like l-dopa and dopamine (DA) agonists have declined efficacy after long term use. Therefore, research towards supplementary or alternative medication is needed. The implementation in PD can be expedited by application of compounds already used in the clinic. In this study the therapeutic effects of...
article 2008
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TNO Defensie en Veiligheid (author), van Vliet, S.A.M. (author), Jongsma, M.J. (author), Vanwersch, R.A.P. (author), Olivier, B. (author), Philippens, I.H.C.H.M. (author)
article 2008
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TNO Defensie en Veiligheid (author), Philippens, I.H.C.H.M. (author), Jongsma, M.J. (author), Joosen, M.J.A. (author), Bouwman, G. (author), Vanwersch, R.A.P. (author)
Compounds with another mechanism of action than enzyme inhibition alone were tested in their capability to counteract or prevent incapacitation and lethality after 2xLD50 soman when used as a pretreatment or as a post-intoxication therapy in guinea pigs. To increase the validity of extrapolating data to man, crucial experiments were performed in...
conference paper 2007
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TNO Defensie en Veiligheid (author), van Vliet, S.A.M. (author), Vanwersch, R.A.P. (author), Jongsma, M.J. (author), van der Gugten, J. (author), Olivier, B. (author), Philippens, I.H.C.H.M. (author)
The vigilance-enhancing agent modafinil has neuroprotective properties: it prevents striatal ischemic injury, nigrostriatal pathway deterioration after partial transsection and intoxication with 1-methyl-1,2,3,6-tetrahydropyridine. The present study determines the protective effects of modafinil in the marmoset 1-methyl-1,2,3,6...
article 2006
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TNO Defensie en Veiligheid (author), van Vliet, S.A.M. (author), Jongsma, M.J. (author), Vanwersch, R.A.P. (author), Olivier, B. (author), Philippens, I.H.C.H.M. (author)
Rationale: Modafinil is increasingly used in sleep disturbances in general and in neurodegenerative diseases and is recently being used in healthy people for attention control. However, the application of modafinil is possibly not only restricted to alertness enhancing effects. More insight in this compound may lead to new applications. Not all...
article 2006
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TNO Defensie en Veiligheid (author), Philippens, I.H.C.H.M. (author), Joosen, M.J.A. (author), Vanwersch, R.A.P. (author)
During military operations, soldiers may be exposed to mixtures of chemicals and to physical, emotional and psychological stress factors, which all may influence efficacy of any treatment, including the nerve agent pretreatment regimen. The purpose of this study was therefore to investigate the influence of chronic intermittent, variable,...
article 2005
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Philippens, I.H.C.H.M. (author), Jongsma, M.J. (author), Vanwersch, R.A.P. (author), Prins Maurits Laboratorium TNO (author)
The efficacy against lethality and post-intoxication incapacitation after 2x LD50 soman of different subacute pretreatment scenarios of 12 days was tested with or without post-intoxication therapy in guinea pigs. These pretreatment regimes were 1) the currently used pretreatment with pyridostigmine (PYR, 0.04 mg/kg/hr), 2) the combination of...
conference paper 2004
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van Helden, H.H.P.M. (author), Vanwersch, R.A.P. (author), Kuijpers, W.C. (author), Trap, H.C. (author), Philippens, I.H.C. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
The main purpose of this pilot study was to estimate the lowest observable adverse effect level (LOAEL) for the electroencephalogram (EEG) upon long-term, low-level exposure of vehicle-pretreated and pyridostigmine-pretreated marmoset monkeys to sarin vapour. This is the C·t value (t = 5 h) of exposure at which the EEG becomes significantly...
article 2004
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van Helden, H.P.M. (author), Trap, H.C. (author), Kuijpers, W.C. (author), Oostdijk, J.P. (author), Vanwersch, R.A.P. (author), Phillippens, I.H.C.H.M. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
Realistic scenarios for low-level exposure to nerve agents will often involve exposures over several hours to extremely low doses of agent. The purpose of this pilot study was to indicate for sarin: (i) the lowest observable effect level (LOEL), i.e., the C.t-value (t = 5 h) of exposure at which an internal dose (fluoride-regenerated sarin from...
conference paper 2004
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Philippens, I.H.C.H.M. (author), Joosen, M.J.A. (author), Groen, B. (author), Vanwersch, R.A.P. (author), Busker, R.W. (author), Nieuwenhuizen, M.S. (author)
During research efforts towards finding effective drugs are performed in a standard laboratory situation. However, in a more realistic situation other factors may interfere with the treatment regime. There is growing evidence that stress occurring during military operations can impair the efficacy and appearance of side effects of medical...
conference paper 2001
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van Helden, H.P.M. (author), Trap, H.C. (author), Kuijpers, W.C. (author), Groen, B. (author), Oostdijk, J.P. (author), Vanwersch, R.A.P. (author), Phillippens, I.H.C.H.M. (author), Langenberg, J.P. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
conference paper 2001
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Trap, H.C. (author), Kuijpers, W.C. (author), Groen, B. (author), Oostdijk, J.P. (author), Vanwersch, R.A.P. (author), Phillippens, I.H.C. (author), Langenberg, J.P. (author), Benschop, H.P. (author), van Helden, H.P.M. (author)
The purpose of the present study was to establish for both saline-pretreated and pyridostigmine-pretreated conscious guinea pigs whole-body exposed to low levels of GB vapor: (i) The Lowest Observable Effect Level (LOEL) for GB, i.e., the C.t-value (t = 5-h) of exposure at which an internal dose (fluoride-regenerated GB from blood ChE) becomes...
conference paper 2000
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Wolthuis, O.L. (author), Philippens, I.H.C.H.M. (author), Vanwersch, R.A.P. (author), Medisch Biologisch Laboratorium TNO (author), MBL (author)
Several earlier studies showed that, in contrast with DFP, repeated injections with soman did not lead to behavioral tolerance in rats. The reason for the difference between the effects of these two organophosphate cholinesterase inhibitors was not clear and a neurophysiological approach was undertaken. Four experiments (A, B, C and D) were...
article 1991
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Medisch Biologisch Laboratorium TNO (author), Kulig, B.M. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author)
The effects of CNS-active drugs and neurotoxic agents on motor coordination in the rat were studied using a newly developed, automated technique. In this test, a tv/microprocessor-based system was utilized to detect and describe the movement and placement characteristics of one of the rat's hindpaws as the rat placed its paw from one rung to...
article 1985
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Wolthuis, O.L. (author), Vanwersch, R.A.P. (author), Medisch Biologisch Laboratorium TNO (author)
article 1984
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...
article 1981
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Tanger, H.J. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
A method is described whereby open field behaviour of rats can be automatically registered using a TV camera, a video converter, an X-Y recorder and a papertape puncher. Use is made of the scanning properties of the TV camera to obtain the X and Y coordinates of the rat's position and to print this position on an X-Y recorder to obtain the...
article 1978
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