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van Son, K.C. (author), Verschuren, L. (author), Hanemaaijer, R. (author), Reeves, H. (author), Takkenberg, R.B. (author), Drenth, J.P.H. (author), Tushuizen, M.E. (author), Holleboom, A.G. (author)
Hepatocellular carcinoma (HCC) in the setting of non-alcoholic fatty liver disease (NAFLD)-related cirrhosis and even in the pre-cirrhotic state is increasing in incidence. NAFLD-related HCC has a poor clinical outcome as it is often advanced at diagnosis due to late diagnosis and systemic treatment response is poor due to reduced immune...
article 2023
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van der Zijl, N.J. (author), Hanemaaijer, R. (author), Tushuizen, M.E. (author), Schindhelm, R.K. (author), Boerop, J. (author), Rustemeijer, C. (author), Bilo, H.J. (author), Verheijen, J.H. (author), Diamant, M. (author), TNO Kwaliteit van Leven (author)
Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity in patients with type 2 diabetes mellitus (T2DM) is related to a decline in renal function. We determined MMP-2, -8 and -9 activity in 24-h urine collections in relation to risk factors...
article 2010