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Willems, N. (author), Yang, H.Y. (author), Langelaan, M.L.P. (author), Tellegen, A.R. (author), Grinwis, G.C.M. (author), Kranenburg, H.J.C. (author), Riemers, F.M. (author), Plomp, S.G.M. (author), Craenmehr, E.G.M. (author), Dhert, W.J.A. (author), Papen-Botterhuis, N.E. (author), Meij, B.P. (author), Creemers, L.B. (author), Tryfonidou, M.A. (author)Introduction: Chronic low back pain due to intervertebral disc (IVD) degeneration is associated with increased levels of inflammatory mediators. Current medical treatment consists of oral anti-inflammatory drugs to alleviate pain. In this study, the efficacy and safety of a novel thermoreversible poly-N-isopropylacrylamide MgFe-layered double...article 2015
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Yang, H.Y. (author), van Ee, R.J. (author), Timmer, K. (author), Craenmehr, E.G.M. (author), Huang, J.H. (author), Öner, C. (author), Dhert, W.J.A. (author), Kragten, A.H.M. (author), Willems, N. (author), Grinwis, G.C.M. (author), Tryfonidou, M.A. (author), Papen-Botterhuis, N.E. (author), Creemers, L.B. (author)Hybrid hydrogels composed of poly(N-isopropylacrylamide) (pNIPAAM) and layered double hydroxides (LDHs) are presented in this study as novel injectable and thermoresponsive materials for siRNA delivery, which could specifically target several negative regulators of tissue homeostasis in cartilaginous tissues. Effectiveness of siRNA transfection...article 2015
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Tryfonidou, M.A. (author), Holl, M.S. (author), Stevenhagen, J.J. (author), Buurman, C.J. (author), Deluca, H.F. (author), Oosterlaken-Dijksterhuis, M.A. (author), van den Brom, W.E. (author), van Leeuwen, J.P.T.M. (author), Hazewinkel, H.A.W. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)The effects of excessive non-toxic dietary Vitamin D3 supplementation on Ca homeostasis with specific effects on endochondral ossification and skeletal remodeling were investigated in a group of growing Great Dane dogs supplemented with cholecalciferol (Vitamin D3; HVitD) versus a control group (CVitD) (1350 μg versus 11.4 μg Vitamin D3 per...article 2003
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Tryfonidou, M.A. (author), Stevenhagen, J.J. (author), van den Bemd, G.J.C.M. (author), Oosterlaken-Dijksterhuis, M.A. (author), Deluca, H.F. (author), Mol, J.A. (author), van den Brom, W.E. (author), van Leeuwen, J.P.T.M. (author), Hazewinkel, H.A.W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Hormonal regulation of calcium (Ca) absorption was investigated in a cholecalciferol (vitamin D3)supplemented group (hVitD) vs. a control group (cVitD) of growing Great Danes (100 vs. 12.5 μg vitamin D3/kg diet). Although Ca intakes did not differ, fractional Ca absorption was significantly lower in the hVitD group than in the cVitD group. There...article 2002