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Subchronic (13-week) oral toxicity study of y-cyclodextrin in dogs

Til, H.P. (author), Bär, A. (author)

The oral toxicity of γ-cyclodextrin (γ- CD) was examined in a 13-week feeding study in which four groups of four male and four female Beagle dogs received γ-CD in the diet at concentrations of 0 (control), 5, 10, or 20%. No treatment-related changes were noted in behavior or appearance of the dogs and no mortalities occurred. Transient diarrhea...

article 1998

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Chronic toxicity and carcinogenicity study of erythritol in rats

Lina, B.A.R. (author), Bos-Kuijpers, M.H.M. (author), Til, H.P. (author), Bär, A. (author)

The potential toxicity and carcinogenicity of erythritol, a low-calorie sugar substitute, were examined in Wistar Crl:(WI) WU BR rats. Groups of 50 rats of each sex consumed diets with 0, 2, 5, or 10% erythritol, or 10% mannitol, for a period of 104-107 weeks. To each of these main groups, two satellite groups of 20 males each were attached for...

article 1996

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Four-week oral toxicity study with erythritol in rats

Til, H.P. (author), Modderman, J. (author), TNO Voeding (author)

Erythritol was orally administered to Wistar rats at dietary levels of 0, 5, and 10% for 4 weeks. Soft stools and diarrhea were observed in male and female animals of the 10% group and in female animals of the 5% group. These symptoms disappeared during the course of the study. Mean body weights of male rats in the high-dose group were...

article 1996

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Subchronic oral toxicity studies with erythritol in mice and rats

Til, H.P. (author), Kuper, C.F. (author), Falke, H.E. (author), Bär, A. (author)

Erythritol is a sugar alcohol (polyol) with potential applications as a low-calorie, bulk sweetener. Ingested erythritol is efficiently absorbed and excreted unchanged via the urine since it is not metabolized systemically by the animal or human body. Erythritol was administered to four groups of 10 male and 10 female Swiss CD-1 mice and four...

article 1996

document

Subchronic oral toxicity study with regular and enzymatically depolymerized sodium carboxymethylcellulose in rats

Bär, A. (author), Til, H.P. (author), Timonen, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

article 1995

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Subchronic toxicity experiments with potassium nitrite in rats

Til, H.P. (author), Kuper, C.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

conference paper 1995

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Human diets cooked by microwave or conventionally: Comparative sub-chronic (13-wk) toxicity study in rats

Jonker, D. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

To compare the possible effects of microwave and conventional cooking on a range of common dietary components, mixed human diets containing beef, potatoes and vegetables were fed to groups of 10 male and 10 female Wistar rats for 13 wk. The diet ingredients were cooked by either of the methods in a normal and an abused manner, the latter...

article 1995

document

Neonatal pigs as model animals for studying protein hydrolysates

Tolman, G.H. (author), Til, H.P. (author), Maire, J.C. (author), Schiffrin, E. (author), Huggett, A.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

conference paper 1995

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Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: Comparison with the toxicity of the individual compounds

Centraal Instituut voor Voedingsonderzoek TNO (author), Jonker, D. (author), Woutersen, R.A. (author), van Bladeren, P.J. (author), Til, H.P. (author), Feron, V.J. (author)

In a 4-wk study, 10-wk-old Wistar rats were fed the nephrotoxins hexachloro-1,3-butadiene (HCBD), mercuric chloride, d-limonene and lysinoalanine either alone or in combination. These nephrotoxins damage epithelial cells of the proximal tubules, but by different mechanisms. Each chemical was given alone at a Minimum-Nephrotoxic-Effect Level ...

article 1993

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Subchronic and chronic toxicity/carcinogenicity feeding studies with lactitol in rats

Instituut CIVO-Toxicologie en Voeding TNO (author), Sinkeldam, E.J. (author), Woutersen, R.A. (author), Hollanders, V.M.H. (author), Til, H.P. (author), van Garderen-Hoetmer, A. (author)

The toxicity and possible carcinogenicity of lactitol, a lactose-derived reduced calorie sugar substitute, were examined in Wistar Cpb:WU rats. In a first 13-week study, groups of 10 weanling rats of each sex were fed diets containing 0, 5, 10, or 20% lactitol, or 25% lactose. In a second 13-week study, groups of 20 rats of each sex received...

article 1992

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Chronic toxicity and carcinogenicity study of lactitol in mice

Instituut CIVO-Toxicologie en Voeding TNO (author), Til, H.P. (author), Hollanders, V.M.H. (author), Woutersen, R.A. (author), Bär, A. (author)

Lactitol is a sweet-tasting disaccharide sugar alcohol with potential applications as a reduced calorie sugar substitute. In a chronic toxicity/carcinogenicity study, groups of 50 male and 50 female Cpb:Swiss random (SPF) mice received diets containing 0, 2, 5, and 10% lactitol for 104 weeks. The test compound was added to the diet at the...

article 1992

document

4-Week oral toxicity study of a combination of eight chemicals in rats: comparison with the toxicity of the individual compounds

Centraal Instituut voor Voedingsonderzoek TNO (author), Jonker, D. (author), Woutersen, R.A. (author), van Bladeren, P.J. (author), Til, H.P. (author), Feron, V.J. (author)

In a 4-wk oral toxicity study, 4-wk-old male and female Wistar rats were exposed to a combination of arbitrarily chosen chemicals comprising sodium metabisulphite, Mirex, Loperamide, metaldehyde, di-n-octyltin dichloride, stannous chloride, lysinoalanine and potassium nitrite. The dose levels used were based on the 'no-observed-adverse-effect...

article 1990

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Chronic (89-week) feeding study with hydroxypropyl distarch phosphate, starch acetate, lactose and sodium alginate in mice

Til, H.P. (author), Feron, V.J. (author), Immel, H.R. (author), Vogel, W.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author)

article 1986

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Lifespan oral toxicity study of vinyl chloride in rats

Feron, V.J. (author), Hendriksen, C.F.M. (author), Speek, A.J. (author), Til, H.P. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

A lifespan oral toxicity of vinyl chloride monomer (VCM) was carried out in Wistar rats, using five groups each of 60-80 males and 60-80 females. VCM was administered by incorporating polyvinyl chloride (PVC) powder with a high VCM content into the diet or by gastric intubation of a 10% VCM solution in soya-bean oil. The VCM doses (actual...

article 1981

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One-year time sequence inhalation toxicity study of vinyl chloride in rats. I. Growth, mortality, haematology, clinical chemistry and organ weights

Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Wistar rats were exposed to atmospheres containing 0 (control) or 5000 ppm vinyl chloride monomer (VCM), 7 h/day, 5 days/week, for a period of 52 weeks. After 4, 13, 26 and 52 weeks each time 10 rats/sex/group were killed and subjected to extensive examinations. The present paper deals with growth, mortality, haematology, clinical chemistry and...

article 1979

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Repeated exposure to butenolide vapour: Subacute study in Syrian golden hamsters

Feron, V.J. (author), Kruysse, A. (author), Immel, H.R. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, salivation, nasal discharge,...

article 1979

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Repeated exposure to acrolein vapour: Subacute studies in hamsters, rats and rabbits

Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)

The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 hr/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal...

article 1978

document

Safety evaluation of yeast grown on hydrocarbons. II: One-year feeding study in rats with yeast grown on pure n-paraffins

de Groot, A.P. (author), Til, H.P. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Yeast grown on hydrocarbons according to the n-paraffin process of The British Petroleum Company Ltd. was fed to groups of male and female rats at dietary levels of 10, 20 and 30% for 1 yr. Two control diets were used, one being similar to the yeast diet but with soya-bean meal substituted for yeast and the other being the institute's stock diet...

article 1970

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Safety evaluation of yeast grown on hydrocarbons. I: One-year feeding study in rats with yeast grown on gas oil

de Groot, A.P. (author), Til, H.P. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Yeast grown on hydrocarbons according to the gas-oil process was fed to rats at dietary levels of 10, 20 or 30% for 1 yr. Two control diets were used, one being similar to the yeast diets but containing soyabean-oil meal instead of yeast and the other being the institute's stock diet. The yeast diets had no effect on mortality, general condition...

article 1970

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Toxicologic and pharmacologic properties of iocetamic acid, a new oral cholecystographic agent

Centraal Instituut voor Voedingsonderzoek TNO (author), Janbroers, J.M. (author), Sanders, J.C. (author), Til, H.P. (author), Feron, V.J. (author), de Groot, A.P. (author)

Studies in rats on iocetamic acid show that the LD50 levels of this compound compare favorably with those of a number of other oral cholecystographic agents. Pathologic effects are not found in rats and cats in studies of the subacute toxicity. Incompatibility with an anesthetic or a tranquilizer is not found. The elimination pattern of...

article 1969