Searched for: author%3A%22Tibboel%2C+D.%22
(1 - 8 of 8)
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van Groen, B.D. (author), van Duijn, E. (author), de Vries, A. (author), Mooij, M.G. (author), Tibboel, D. (author), Vaes, W.H.J. (author), de Wildt, S.N. (author)
Growth and development affect drug-metabolizing enzyme activity thus could alter the metabolic profile of a drug. Traditional studies to create metabolite profiles and study the routes of excretion are unethical in children due to the high radioactive burden. To overcome this challenge, we aimed to show the feasibility of an absorption,...
article 2020
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Kleiber, N. (author), Calvier, E. (author), Mooij, M.G. (author), Krekels, E.H.J. (author), Vaes, W.H.J. (author), Tibboel, D. (author), Knibbe, C.A.J. (author), de Wildt, S.N. (author)
OBJECTIVES: Decreasing morbidity and mortality by rationalizing drug treatment in the critically ill is of paramount importance but challenging as the underlying clinical condition may lead to large variation in drug disposition and response. New microtracer methodology is now available to gain knowledge on drug disposition in the intensive care...
article 2019
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van Groen, B.D. (author), Vaes, W.H. (author), Park, B.K. (author), Krekels, E.H.J. (author), van Duijn, E. (author), Korgvee, L.T. (author), Maruszak, W. (author), Grynkiewicz, G. (author), Garner, R.C. (author), Knibbe, C.A.J. (author), Tibboel, D. (author), de Wildt, S.N. (author), Turner, M.A. (author)
Aims: Drug disposition in children may vary from adults due to age-related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [14C]midazolam microdose, by comparing the PK of an...
article 2019
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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)
Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...
article 2018
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Mooij, M.G. (author), van de Steeg, E. (author), van Rosmalen, J. (author), Windster, J.D. (author), de Koning, B.A.E. (author), Vaes, W.H.J. (author), van Groen, B.D. (author), Tibboel, D. (author), Wortelboer, H.M. (author), de Wildt, S.N. (author)
Human hepatic membrane-embedded transporter proteins are involved in trafficking endogenous and exogenous substrates. Even though impact of transporters on pharmacokinetics is recognized, little is known on maturation of transporter protein expression levels, especially during early life. We aimed to study the protein expression of 10...
article 2016
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Mooij, M.G. (author), van Duijn, E. (author), Knibbe, C.A.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Vaes, W.H.J. (author), Spaans, E. (author), Fabriek, B.O. (author), Sandman, H. (author), Grossouw, D. (author), Hanff, L.M. (author), Janssen, P.J.J.M. (author), Koch, B.C.P. (author), Tibboel, D. (author), de Wildt, S.N. (author)
Results: Ten infants (aged 0.1–83.1 months) were included; one was excluded as he vomited shortly after administration. In nine patients, [14C]AAP and metabolites in blood samples were detectable at expected concentrations: median (range) maximum concentration (Cmax) [14C]AAP 1.68 (0.75–4.76) ng/L, [14C]AAP-Glu 0.88 (0.34–1.55) ng/L, and [14C...
article 2014
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Hulst, J. (author), Joosten, K. (author), Zimmermann, L. (author), Hop, W. (author), van Buuren, S. (author), Büller, H. (author), Tibboel, D. (author), van Goudoever, J. (author), TNO Preventie en Gezondheid (author)
Background & Aims: Little is known about the nutritional status of critically ill children during hospitalisation in and after discharge from an intensive care unit. We set up a prospective, observational study to evaluate the nutritional status of children in an intensive care unit from admission up to 6 months after discharge. A secondary aim...
article 2004
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Peters, J.W.B. (author), Koot, H.M. (author), Grunau, R.E. (author), de Boer, J. (author), van Druenen, M.J. (author), Tibboel, D. (author), Duivenvoorden, H.J. (author), TNO Preventie en Gezondheid (author)
Objective: The objectives of this study were to: (1) evaluate the validity of the Neonatal Facial Coding System (NFCS) for assessment of postoperative pain and (2) explore whether the number of NFCS facial actions could be reduced for assessing postoperative pain. Design: Prospective, observational study. Patients: Thirty-seven children (0-18...
article 2003
Searched for: author%3A%22Tibboel%2C+D.%22
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