Searched for: author:"Thissen, U."
(1 - 13 of 13)
document
Krishnan, S. (author), Verheij, E.E.R. (author), Bas, R.C. (author), Hendriks, M.W.B. (author), Hankemeier, T. (author), Thissen, U. (author), Coulier, L. (author)
RATIONALE Mass spectra obtained by deconvolution of liquid chromatography/high-resolution mass spectrometry (LC/HRMS) data can be impaired by non-informative mass-over-charge (m/z) channels. This impairment of mass spectra can have significant negative influence on further post-processing, like quantification and identification. METHODS A metric...
article 2013
document
Tapp, H.S. (author), Radonjic, M. (author), Kemsley, E.K. (author), Thissen, U. (author)
Genomics-based technologies produce large amounts of data. To interpret the results and identify the most important variates related to phenotypes of interest, various multivariate regression and variate selection methods are used. Although inspected for statistical performance, the relevance of multivariate models in interpreting biological...
article 2012
document
Krishnan, S. (author), Vogels, J.T.W.E. (author), Coulier, L. (author), Bas, R.C. (author), Hendriks, M.W.B. (author), Hankemeier, T. (author), Thissen, U. (author)
Setting appropriate bin sizes to aggregate hyphenated high-resolution mass spectrometry data, belonging to similar mass over charge (m/. z) channels, is vital to metabolite quantification and further identification. In a high-resolution mass spectrometer when mass accuracy (ppm) varies as a function of molecular mass, which usually is the case...
article 2012
document
Coulier, L. (author), Tas, A. (author), Thissen, U. (author)
Comprehensive analysis of both volatile and non-volatile metabolites in food combined with information on sensory properties and multivariate statistics can be a valuable tool in understanding and improving the taste of food. Performing food metabolomics studies is, however, challenging and requires the analytical measurements to be of a very...
article 2011
document
Thissen, U. (author), Coulier, L. (author), Overkamp, K.M. (author), Jetten, J. (author), van de Werff, B.J.C. (author), van de Ven, T. (author), van der Werf, M.J. (author)
In agricultural and food products, typical quality parameters are sensory properties, shelf-life, safety, health, nutritional value, crop yield per area and disease resistance. It is known that these parameters are importantly determined by the metabolites in the crops and food products. Metabolomics is the state-of-the-art routine technique...
article 2011
document
Coulier, L. (author), Bas, R. (author), Hekman, M. (author), van der Werff, B.J.C. (author), Burgering, M. (author), Thissen, U. (author)
An ion-pair LC-ESI-MS method was developed capable of analyzing various reported umami or umami-enhancing compounds, including glutamic acid and 5'-ribonucleotides. The method was validated using tomato and potato samples and showed overall good analytical performance with respect to selectivity, detection limit, linearity, and repeatability....
article 2011
document
van de Ven, P. (author), Bijlsma, S. (author), Gout, E. (author), van der Voort Maarschalk, K. (author), Thissen, U. (author)
Introduction: The aim of this study was to develop and demonstrate a framework assuring efficient process development using fewer experiments than standard experimental designs. Methods: A novel optimality criterion for experimental designs (Iw criterion) is defined that leads to more efficient process development because: (a) prior knowledge is...
article 2011
document
Rubingh, C. (author), Thissen, U. (author), van de Voort Maarschalk, K. (author), TNO Kwaliteit van Leven (author)
Statistics are often viewed as confusing and complicated, but multivariate data analysis (MVA) methods can be used to amass knowledge simply. MVA can increase the quality and yield of production processes by elucidating hidden knowledge and identifying opportunities for adaptation using historical or routine data. An application in...
article 2010
document
Duval, C. (author), Thissen, U. (author), Keshtkar, S. (author), Accart, B. (author), Stienstra, R. (author), Boekschoten, M.V. (author), Roskams, T. (author), Kersten, S. (author), Müller, M. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE - Nonalcoholic fatty liver disease (NAFLD) is linked to obesity and diabetes, suggesting an important role of adipose tissue in the pathogenesis of NAFLD. Here, we aimed to investigate the interaction between adipose tissue and liver in NAFLD and identify potential early plasma markers that predict nonalcoholic steatohepatitis (NASH)....
article 2010
document
Thissen, U. (author), Wopereis, S. (author), van den Berg, S.A.A. (author), Bobeldijk, I. (author), Kleemann, R. (author), Kooistra, T. (author), van Dijk, K.W. (author), van Ommen, B. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)
Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study design can be used to decompose the total data...
article 2009
document
Geert Heidema, A. (author), Thissen, U. (author), Boer, J.M.A. (author), Bouwman, F.G. (author), Feskens, E.J.M. (author), Mariman, E.C.M. (author), TNO Kwaliteit van Leven (author)
In this study, we applied the multivariate statistical tool Partial Least Squares (PLS) to analyze the relative importance of 83 plasma proteins in relation to coronary heart disease (CHD) mortality and the intermediate end points body mass index, HDL-cholesterol and total cholesterol. From a Dutch monitoring project for cardiovascular disease...
article 2009
document
Hendriksen, P.J.M. (author), Freidig, A.P. (author), Jonker, D. (author), Thissen, U. (author), Bogaards, J.J.P. (author), Mumtaz, M.M. (author), Groten, J.P. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)
The present research aimed to study the interaction of three chemicals, methyl mercury, benzene and trichloroethylene, on mRNA expression alterations in rat liver and kidney measured by microarray analysis. These compounds were selected based on presumed different modes of action. The chemicals were administered daily for 14 days at the Lowest...
article 2007
document
Chang, W.T. (author), Thissen, U. (author), Ehlert, K.A. (author), Koek, M.M. (author), Jellema, R.H. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author), TNO Kwaliteit van Leven TNO Voeding (author)
Metabolite profiling in combination with multivariate statistics is a sophisticated method for quality assessment of natural products. For the development of a quality control strategy in Traditional Chinese Medicine (TCM), we have measured the metabolite fingerprints of Rehmannia glutinosa by GC-MS. Plants were grown under different climate and...
article 2006
Searched for: author:"Thissen, U."
(1 - 13 of 13)