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TNO Kwaliteit van Leven Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)ln 2018 komt er een einde aan de aanwezigheid van TNO aan de Utrechtseweg 48 in Zeist. Duizenden TNO'ers (en bezoekers) zijn gedurende vele jaren het markante gebouw met de nog markantere trap binnengekomen en hebben gedurende die jaren daar hun beste krachten gegeven. Wanneer het gebouw kon spreken, dan zouden we wellicht versteld staan wat er...book 2017
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TNO Voeding (author), Janus, M.M. (author), Volgenant, C.M.C. (author), Brandt, B.W. (author), Buijs, M.J. (author), Keijser, B.J.F. (author), Crielaard, W. (author), Zaura, E. (author), Krom, B.P. (author)Gingivitis is one of the most common oral infections in humans. While sugar alcohols such as erythritol are suggested to have caries-preventive properties, it may also have beneficial effects in prevention of gingivitis by preventing maturation of oral biofilms. The aim of this study was to assess the effect of erythritol on the microbial...article 2017
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TNO Voeding (author), Fransman, W. (author), Buist, H. (author), Kuijpers, E. (author), Walser, T. (author), Meyer, D. (author), Zondervan-van den Beuken, E. (author), Westerhout, J. (author), klein Entink, R.H. (author), Brouwer, D.H. (author)For safe innovation, knowledge on potential human health impacts is essential. Ideally, these impacts are considered within a larger life-cycle-based context to support sustainable development of new applications and products. A methodological framework that accounts for human health impacts caused by inhalation of engineered nanomaterials (ENMs...article 2017
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TNO Voeding (author), Eelderink, C. (author), Noort, M.W.J. (author), Sozer, N. (author), Koehorst, M. (author), Holst, J.J. (author), Deacon, C.F. (author), Rehfeld, J.F. (author), Poutanen, K. (author), Vonk, R.J. (author), Oudhuis, L. (author), Priebe, M.G. (author)Purpose: Underlying mechanisms of the beneficial health effects of low glycemic index starchy foods are not fully elucidated yet. We varied the wheat particle size to obtain fiber-rich breads with a high and low glycemic response and investigated the differences in postprandial glucose kinetics and metabolic response after their consumption....article 2017
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- TNO Voeding (author), Jones, B. (author), Schoen, E.D. (author), Montgomery, D.C. (author) article 2016
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TNO Voeding (author), Notermans, S.H.W. (author), Stam, C.N. (author), Behar, A.E. (author)Botulism is caused by an exotoxin produced by the sporeforming bacterium Clostridium botulinum. Of the seven different toxin types, A, B, and E are the types commonly implicated in foodborne outbreaks of botulism. Clostridium botulinum toxins are extremely potent neurotoxins and generally occur at low concentrations in implicated foods. The...bookPart 2014
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TNO Voeding (author), Fleuren, W.W.M. (author), Toonen, E.J.M. (author), Verhoeven, S. (author), Frijters, R. (author), Hulsen, T. (author), Rullmann, T. (author), van Schaik, R. (author), de Vlieg, J. (author), Alkema, W. (author)Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. To gain more insight into the mechanisms...article 2013
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TNO Kwaliteit van Leven TNO Voeding (author), Leavis, H.L. (author), Willems, R.J.L. (author), van Wamel, W.J.B. (author), Schuren, F.H. (author), Caspers, M.P.M. (author), Bonten, M.J.M. (author)Enterococcus faecium, an ubiquous colonizer of humans and animals, has evolved in the last 15 years from an avirulent commensal to the third most frequently isolated nosocomial pathogen among intensive care unit patients in the United States. E. faecium combines multidrug resistance with the potential of horizontal resistance gene transfer to...article 2007
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TNO Kwaliteit van Leven TNO Voeding (author), van den Brandt, P.A. (author), Smits, K.M. (author), Goldbohm, R.A. (author), Weijenberg, M.P. (author)Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across...article 2007
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Wilkinson, S.C. (author), Maas, W.J.M. (author), Nielsen, J.B. (author), Greaves, L.C. (author), van de Sandt, J.J.M. (author), Williams, F.M. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objectives: To determine the effect of skin thickness on the percutaneous penetration and distribution of test compounds with varying physicochemical properties using in vitro systems. Studies were carried out in accordance with OECD guidelines on skin absorption tests. Methods: Percutaneous penetration of caffeine (log P -0.01), testosterone ...article 2006
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Don, C. (author), Mann, G. (author), Bekes, F. (author), Hamer, R.J. (author), TNO Kwaliteit van Leven TNO Voeding (author)Using a unique set of deletion lines, (Olympic×Gabo, varying in high molecular weight glutenin subunit (HMW-GS) composition, but with the same genetic background) it was shown that the presence of glutenin particles in glutenin macropolymer (GMP) is directly related to the presence of certain HMW-GS. In the absence of HMW-GS only a small amount...article 2006
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Haaksman, I.K. (author), Besemer, A.C. (author), Jetten, J.M. (author), Timmermans, J.W. (author), Slaghek, T.M. (author), TNO Kwaliteit van Leven TNO Voeding (author)This paper describes the difference in relative reactivity of the aldehyde groups present in dialdehyde starch towards different oxidising agents. The oxidation of dialdehyde starch with peracetic acid and sodium bromide leads to only partial oxidation to give mono-aldehyde-carboxy starch, while oxidation with sodium chlorite results in...article 2006
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Coulier, L. (author), Bas, R. (author), Jespersen, S. (author), Verheij, E. (author), van der Werf, M.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven TNO Voeding (author)We have developed an analytical method, consisting of ion-pair liquid chromatography coupled to electrospray ionization mass spectrometry (IP-LC-ESI-MS), for the simultaneous quantitative analysis of several key classes of polar metabolites, like nucleotides, coenzyme A esters, sugar nucleotides, and sugar bisphosphates. The use of the ion-pair...article 2006
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Rein, D. (author), Schijlen, E. (author), Kooistra, T. (author), Herbers, K. (author), Verschuren, L. (author), Hall, R. (author), Sonnewald, U. (author), Bovy, A. (author), Kleemann, R. (author), TNO Kwaliteit van Leven TNO Voeding (author)The increased consumption of fruits and vegetables is associated with reduced cardiovascular disease. The molecular basis of this health effect is not fully understood, yet dietary flavonoids are thought to play an important role. Genetic engineering has enabled us to overexpress specific flavonoids (flavones and flavonols) in tomato fruit....article 2006
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A pooled analysis of 12 cohort studies of dietary fat, cholesterol and egg intake and ovarian cancerGenkinger, J.M. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Beeson, W.L. (author), Buring, J.E. (author), Colditz, G.A. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Hankinson, S.E. (author), Koenig, K.L. (author), Larsson, S.C. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Rodriguez, C. (author), Rohan, T.E. (author), Ross, J.A. (author), Schatzkin, A. (author), Schouten, L.J. (author), Smit, E. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Fat and cholesterol are theorized to promote ovarian carcinogenesis by increasing circulating estrogen levels. Although case-control studies have reported positive associations between total and saturated fat intake and ovarian cancer risk, two cohort studies have observed null associations. Dietary cholesterol and eggs have been positively...article 2006
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Biesma, R.G. (author), Schouten, L.J. (author), Dirx, M.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objective: To investigate the association between nonoccupational physical activity and the risk of ovarian cancer among post-menopausal women. Methods: The Netherlands Cohort Study on Diet and Cancer consists of 62,573 women aged 55-69 years at baseline. Information regarding baseline nonoccupational physical activity and history of sports...article 2006
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Pasman, W. (author), Wils, D. (author), Saniez, M.H. (author), Kardinaal, A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objective: To determine the gastrointestinal (GI) tolerance of NUTRIOSE®FB in men. Design: A randomized, placebo-contro lled, parallel, double-blind study. Setting: The metabolic ward of TNO Quality of Life. Subjects: Forty-eight subjects started the study: 16 men participated in one of the three treatments. Subjects consumed either 22.5 g of...article 2006
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Arts, J.H.E. (author), de Heer, C. (author), Woutersen, R.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objectives: Chemosensory effects of stimulation by a chemical can either be irritating (trigeminal stimulation) or odorous (olfactory stimulation) or both. For odorous irritants, a clear-cut distinction between odour and irritation is difficult to make. The differences in the lowest concentration found to be irritating to the respiratory tract...article 2006
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Harker, M. (author), Coulson, H. (author), Fairweather, I. (author), Taylor, D. (author), Daykin, C.A. (author), TNO Voeding (author)The aim of the study was to evaluate metabolite variability in human eccrine sweat using a metabonomics based approach. Eccrine sweat is a dilute electrolyte solution whose primary function is to control body temperature via evaporative cooling. Although the composition of sweat is primarily water, previous studies have shown that a diverse...article 2006
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Chang, W.T. (author), Thissen, U. (author), Ehlert, K.A. (author), Koek, M.M. (author), Jellema, R.H. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author), TNO Kwaliteit van Leven TNO Voeding (author)Metabolite profiling in combination with multivariate statistics is a sophisticated method for quality assessment of natural products. For the development of a quality control strategy in Traditional Chinese Medicine (TCM), we have measured the metabolite fingerprints of Rehmannia glutinosa by GC-MS. Plants were grown under different climate and...article 2006