Searched for: author%3A%22TNO+Biomedical+Instrumentation+%22
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Abdul-Hussien, H. (author), Soekhoe, R.G.V. (author), Weber, E. (author), von der Thüsen, J.H. (author), Kleemann, R. (author), Mulder, A. (author), Hajo Van Bockel, J. (author), Hanemaaijer, R. (author), Lindeman, J.H.N. (author), TNO Biomedical Instrumentation (author)
Growth and rupture of abdominal aortic aneurysms (AAAs) result from increased collagen turnover. Collagen turnover critically depends on specific collagenases that cleave the triple helical region of fibrillar collagen. As yet, the collagenases responsible for collagen degradation in AAAs have not been identified. Increased type I collagen...
article 2007
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Guzik, P. (author), Piskorski, J. (author), Krauze, T. (author), Schneider, R. (author), Wesseling, K.H. (author), Wykrȩtowicz, A. (author), Wysocki, H. (author), TNO Biomedical Instrumentation (author)
Aim: To analyze the correlation of the Poincaré plot descriptors of RR intervals with standard measures of heart rate variability (HRV) and spontaneous baroreflex sensitivity (BRS). A physiological model of changing respiratory rates from 6 to 15 breaths/min provided a wide range of RR intervals for analysis. Material and methods: Beat-to-beat...
article 2007
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Wykretowicz, A. (author), Guzik, P. (author), Bartkowiak, G. (author), Krauze, T. (author), Kasinowski, R. (author), Dziarmaga, M. (author), Wesseling, K.H. (author), Wysocki, H. (author), TNO Biomedical Instrumentation (author)
Endothelial dysfunction and reduced BRS (baroreflex sensitivity) may be present in patients with CAD (coronary artery disease). The normal fasting glucose level does not exclude abnormal glucose metabolism in patients with CAD. The aim of present study was to evaluate endothelial function and BRS according to glucose metabolism in patients with...
article 2005
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Meijboom, L.J. (author), Westerhof, B.E. (author), Nollen, G.J. (author), Spaan, J.A.E. (author), de Mol, B.A.J.M. (author), Jacobs, M.J.H.M. (author), Mulder, B.J.M. (author), TNO Biomedical Instrumentation (author)
Objective: β-blocking therapy is the standard therapy in non-operated Marfan patients, however its efficacy after entire aortic replacement is unknown. The aim of this study was to describe the influence of (nearly) entire aortic replacement and β-blocking therapy on blood pressure and wave reflections in Marfan patients. Methods: Four Marfan...
article 2004
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Westerhof, B.E. (author), Gisolf, J. (author), Stok, W.J. (author), Wesseling A, K.H. (author), Karemaker, J.M. (author), TNO Biomedical Instrumentation Technisch Physische Dienst TNO - TH (author)
Objective: To test a new method (cross-correlation baroreflex sensitivity, xBRS) for the computation of time-domain baroreflex sensitivity on spontaneous blood pressure and heart interval variability using the EUROBAVAR data set. Methods: We applied xBRS to the 42 records in the EUROBAVAR data set, obtained from 21 patients in the lying and...
article 2004
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van Lieshout, J.J. (author), Toska, K. (author), van Lieshout, E.J. (author), Eriksen, M. (author), Walløe, L. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)
The proper understanding of the cardiovascular mechanisms involved in complaints of short-lasting dizziness and the evaluation of unexplained recurrent syncope requires continuous monitoring of cardiac stroke volume (SV) in addition to blood pressure and heart rate. The primary aim of the present study was to evaluate a pulse wave analysis...
article 2003
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TNO Biomedical Instrumentation (author), Kingma, R. (author), Voorde, B.J.ten (author), Scheffer, G.J. (author), Karemaker, J.M. (author), Mackaay, A.J.C. (author), Wesseling, K.H. (author), Lange, J.J.de (author)
Endoscopic thoracic sympathectomy at T2-T4 is an effective and safe treatment for primary axillary and palmar hyperhidrosis and facial blushing refractory to conventional treatment. T2 and T4 ganglia however are in the direct pathway of sympathetic innervation of the heart and part of the vasomotor nerves. In this study we investigate possible...
article 2002
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TNO Biomedical Instrumentation (author), Mulder, W.M.C. (author), de Klerk, S. (author), Settels, J.J. (author), van Boxtel, C.J. (author)
Objective: To evaluate the cardiovascular effects over time of a single subcutaneous (SC) dose of terbutaline 0.75mg in young healthy volunteers using continuous, beat-to-beat monitoring of cardiovascular effects. Design and methods: Nine healthy young volunteers were administered a SC dose of terbutaline sulphate 0.75mg. Cardiovascular effects...
article 2002
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TNO Biomedical Instrumentation (author), Jellema, W.T. (author), Groeneveld, A.B.Johan (author), van Goudoever, J. (author), Wesseling, K.H. (author), Westerhof, N. (author), Lubbers, M.J. (author), Kesecioglu, J. (author), van Lieshout, J.J. (author)
OBJECTIVE: The purposes of this study were to investigate the hemodynamic changes induced by intermittent manual lung hyperinflation (MHI) and to assess if these changes are adverse enough to warrant prohibition of MHI as a routine procedure in the care of patients with septic shock. DESIGN: The study's design was experimental prospective....
article 2000
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TNO Biomedical Instrumentation (author), van Popele, N.M. (author), Bos, W.J.W. (author), de Beer, N.A.M. (author), van der Kuip, D.A.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Witteman, J.C.M. (author)
Oscillometric blood pressure devices tend to overestimate systolic blood pressure and underestimate diastolic blood pressure compared with sphygmomanometers. Recent studies indicate that discrepancies in performance between these devices may differ between healthy and diabetic subjects. Arterial stiffness in diabetics could be the underlying...
article 2000
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Castiglioni, P. (author), Parati, G. (author), Omboni, S. (author), Mancia, G. (author), Imholz, B.P.M. (author), Wesseling, K.H. (author), di Rienzo, M. (author), TNO Biomedical Instrumentation (author)
The present study compares the spectral characteristics of 24-h blood pressure variability estimated invasively at the brachial artery level with those estimated by measurement of blood pressure at the finger artery using the non-invasive Portapres device. Broad-band spectra (from 3 x 10<sup>-5</sup> to 0.5 Hz) were derived from both finger and...
article 1999
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Jellema, W.T. (author), Imholz, B.P.M. (author), Oosting, H. (author), Wesseling, K.H. (author), van Lieshout, J.J. (author), TNO Biomedical Instrumentation (author)
Objective: The aim of this study was to compare beat-to-beat changes in stroke volume (SV) estimated by two different pressure wave analysis techniques during orthostatic stress testing: pulse contour analysis and Modelflow, ie, simulation of a three-element model of aortic input impedance. Methods: A reduction in SV was introduced in eight...
article 1999
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Harms, M.P.M. (author), Wesseling, K.H. (author), Pott, F. (author), Jenstrup, M. (author), van Goudoever, J. (author), Secher, N.H. (author), van Lieshout, J.J. (author), TNO Biomedical Instrumentation (author)
The relationship between aortic flow and pressure is described by a three-element model of the arterial input impedance, including continuous correction for variations in the diameter and the compliance of the aorta (Modelflow). We computed the aortic flow from arterial pressure by this model, and evaluated whether, under orthostatic stress,...
article 1999
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Bos, W.J.W. (author), Zietse, R. (author), Wesseling, K.H. (author), Westerhof, N. (author), TNO Biomedical Instrumentation (author)
Background. Arteriovenous (AV) fistulas used for hemodialysis access may affect cardiac load by increasing the preload while decreasing the afterload. In dogs, AV fistulas have also been shown to affect coronary perfusion negatively. We investigated the net effect of AV fistulas on cardiac oxygen supply and demand. Methods. Aortic pressure waves...
article 1999
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Omboni, S. (author), Parati, G. (author), Castiglioni, P. (author), di Rienzo, M. (author), Imholz, B.P.M. (author), Langewouters, G.J. (author), Wesseling, K.H. (author), Mancia, G. (author), TNO Biomedical Instrumentation (author)
Portapres is a noninvasive, beat-to-beat finger blood pressure (BP) monitor that has been shown to accurately estimate 24-hour intra-arterial BP at normal and high BPs. However, no information is available on the ability of this device to accurately track ambulatory BP variability. In 20 ambulatory normotensive and hypertensive subjects, we...
article 1998
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Kornet, L. (author), Jansen, J.R.C. (author), te Nijenhuis, F.C.A.M. (author), Langewouters, G.J. (author), Versprille, A. (author), TNO Biomedical Instrumentation (author)
1. The influence of mean pulmonary arterial pressure (mean P(pa)) on dynamic (C(d)) and pseudostatic compliance (C(ps)) of the pulmonary artery was studied at a constant and a changing heart rate. C(d) is the change in cross-sectional area (CSA) relative to the change in P(pa) throughout a heart cycle. C(pa) is the change in mean CSA relative to...
article 1998
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Stergiopulos, N. (author), Westerhof, B.E. (author), Westerhof, N. (author), TNO Biomedical Instrumentation (author)
We propose a new method to derive aortic pressure from peripheral pressure and velocity by using a time domain approach. Peripheral pressure is separated into its forward and backward components, and these components are then shifted with a delay time, which is the ratio of wave speed and distance, and added again to reconstruct aortic pressure....
article 1998
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Imholz, B.P.M. (author), Wieling, W. (author), van Montfrans, G.A. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)
We review the Finapres technology, embodied in several TNO-prototypes and in the Ohmeda 2300 and 2300e Finapres NIBP. Finapres is an acronym for FINger Arterial PRESsure, the device delivers a continuous finger arterial pressure waveform. Many papers report on the accuracy of the device in comparison with intra-arterial or with noninvasive but...
article 1998
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de Jong-de Vos Van Steenwijk, C.C.E. (author), Wieling, W. (author), Harms, M.P.M. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)
1. Fainting is a common phenomenon in young subjects, but the final events before the actual faint are not well known. The aim of the present study was to study the inter-individual variability of haemodynamic events associated with near-fainting in children and teenagers. 2. Sixty-eight healthy subjects (aged 6-16 years) performed a 70°tilt-up...
article 1997
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Atkins, N. (author), O' Brien, E. (author), Wesseling, K.H. (author), Guelen, I. (author), TNO Biomedical Instrumentation (author)
The most fallible component of blood pressure measurement is the human observer. The traditional technique of measuring blood pressure does not allow the result of the measurement to be checked by independent observers, thereby leaving the method open to bias. In the Sphygmocorder, several components used to measure blood pressure have been...
article 1997
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