Searched for: author:"Sprengers, E.D."
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document
van Hinsbergh, V.W.M. (author), Sprengers, E.D. (author), Kooistra, T. (author), Gaubius Instituut TNO (author)
Human foreskin microvascular endothelial cells synthesize and release tissue-type plasminogen activator (t-PA) in similar amounts as do endothelial cells from umbilical cord artery and vein. Human thrombin increases the production of t-PA by these cells, which could be visualized from 8 h after addition of 0.1-5 units/ml thrombin by fibrin...
article 1987
document
Sprengers, E.D. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Chemicals/CAS: fibrin, 9001-31-4; plasminogen activator inhibitor, 105844-41-5; plasminogen activator, 9039-53-6; Carrier Proteins; Glycoproteins; Plasminogen Activators, EC 3.4.21.-; Plasminogen Inactivators; Protease Inhibitors; protease-nexin
article 1987
document
Gaubius instituut TNO (author), Kooistra, T. (author), Sprengers, E.D. (author), van Hinsbergh, V.W.M. (author)
In conditioned medium (CM) from cultured human endothelial cells, two forms of plasminogen-activator inhibitor (PA-inhibitor) can be demonstrated: a fast-acting active form and an immunologically related, inactive form. Evidence is presented that endothelial cells produce active PA-inhibitor which is rapidly inactivated upon secretion into the...
article 1986
document
Kluft, C. (author), Jie, A.F.H. (author), Sprengers, E.D. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
Inhibition of tissue-type plasminogen activator (t-PA) by pooled plasma could be ascribed for only 60% to the endothelial cell type PA inhibitor. The residual inhibition is ascribed to a so-far undescribed plasma component present at 0.2 nmol/l. This component shows reversible binding to t-PA with an apparent K(i) of 10 pmol/l (does not hinder t...
article 1985
document
van Hinsbergh, V.W.M. (author), Sprengers, E.D. (author), Bertina, R.M. (author), Rijken, D.C. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)
Abstr. no. 378
article 1984
Searched for: author:"Sprengers, E.D."
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