Searched for: author%3A%22Spanhaak%2C+S.%22
(1 - 14 of 14)
document
Janssen, G.B. (author), Penninks, A.H. (author), Knippels, L.M.J. (author), van Zijverden, M. (author), Spanhaak, S. (author), TNO Kwaliteit van Leven (author)
This paper describes studies performed with ERA-63 a low molecular weight pharmaceutical with intended immunomodulatory effects. Since this compound was also known to have estrogenic activity a non-conventional approach was taken in order to differentiate between estrogenic and non-estrogenic-induced immunomodulatory effects. EE was included not...
article 2008
document
Knippels, L.M.J. (author), Houben, G.F. (author), Spanhaak, S. (author), Penninks, A.H. (author)
We developed an oral sensitization protocol for food proteins for the rat. Young Brown Norway (BN) rats were exposed to 1 mg ovalbumin (OVA) by daily gavage dosing for 42 days without the use of an adjuvant. OVA-specific IgE and IgG responses were determined by ELISA. On an oral challenge with OVA some clinical symptoms of food allergy-like...
article 1999
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Bruder, M.C. (author), Spanhaak, S. (author), Bruijntjes, J.P. (author), Michielsen, C.P.P.C. (author), Vos, J.G. (author), Kuper, C.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In order to study the intestinal mucosal immune cells, with emphasis on single T lymphocytcs, an inventory was made of single and organized lymphocytes in the epithelium and lamina propria of the small intestines of untreated Wistar, Fischer 344, and Lewis rats. The single and organized lymphocytes were examined microscopically. In addition, the...
article 1999
document
Verdonk, J.M.A.J. (author), Gerrits, W.J.J. (author), Beekman, S.P.A. (author), Spanhaak, S. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
bookPart 1999
document
Bruder, M.C. (author), Spanhaak, S. (author), Bruijntjes, J.P. (author), Michielsen, C.P.P.C. (author), Vos, J.G. (author), Kuper, C.F. (author)
article 1999
document
Spanhaak, S. (author), Havenaar, R. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To determine the effect of consumption of milk fermented by Lactobacillus casei strain Shirota (L. casei Shirota) on the composition and metabolic activities of the intestinal microflora, and immune parameters in humans. Subjects: Twenty healthy male subjects aged 40-65 years were selected. Design: A placebo-controlled trial was...
article 1998
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van den Heuvel, E.G.H.M. (author), Muys, T. (author), Pellegrom, H. (author), Bruyntjes, J.P. (author), van Dokkum, W. (author), Spanhaak, S. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Iron absorption can be measured by the incorporation of stable iron isotopes into erythrocytes, 14 days after isotope administration. The disadvantage of this method is the high dose of isotopes needed to obtain a sufficient enrichment. Therefore, in this study cell fractions rich in young erythroid cells were prepared by using a density...
article 1998
document
Knippels, L.M.J. (author), Penninks, A.H. (author), Spanhaak, S. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1998
document
Havenaar, R. (author), Spanhaak, S. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
bookPart 1998
document
Knippels, L.M.J. (author), Penninks, A.H. (author), Spanhaak, S. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Although several in vivo antigenicity assays using parenteral immunization are operational, no adequate enteral sensitization models are available to study food allergy and allergenicity of food proteins. Objective: This paper describes the development of an enteral model for food allergy research in the Brown Norway (BN) rat....
article 1998
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de Jong, E.C. (author), van Zijverden, M. (author), Spanhaak, S. (author), Koppelman, S.J. (author), Pellegrom, H. (author), Penninks, A.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Peanuts are a major cause of food allergies both in children as in adults which can induce an anaphylactic shock. The identification and characterization of peanut allergens could lead to more insight into the mechanism and contribute to the improvement of diagnostic tests and treatment for peanut allergy. Objectives: In the present...
article 1998
document
de Jong, E.C. (author), Spanhaak, S. (author), Martens, B.P.M. (author), Kapsenberg, M.L. (author), Penninks, A.H. (author), Wierenga, E.A. (author), TNO Voeding (author)
Background: Increasing evidence indicates a prominent role of allergen-specific TH2 cells, with high IL-4 and IL-5 production and low interferon-γ production, in the regulation of IgE and eosinophil production in allergic disorders. However, most studies have concentrated on T cells reactive with inhalation allergens, whereas little is known...
article 1996
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Mulder, J. (author), Anema, J. (author), de Vrij, V. (author), Spanhaak, S. (author), Kistemaker, C. (author), Ockhuizen, T. (author), Joosten, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1994
document
van 't Veer, P. (author), Kampman, E. (author), Schaafsma, G.J. (author), Spanhaak, S. (author), Ockhuizen, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
bookPart 1992
Searched for: author%3A%22Spanhaak%2C+S.%22
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