The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST

The current allergenicity assessment of novel proteins is based on the EFSA GMO guidance. Recently, EFSA launched a new guidance document on allergenicity assessment of GM plants (2017). This document describes, amongst other topics, the new scientific and regulatory developments on in vitro protein digestibility tests. The EFSA GMO Panel stated...

The Thor suture zone: From subduction to intraplate basin setting

The crustal seismic velocity structure of northwestern Europe shows a low P-wave velocity zone (LVZ) in the lower crust along the Caledonian Thor suture zone (TSZ) that cannot be easily attributed to Avalonia or Baltica plates abutting the TSZ. The LVZ appears to correspond to a hitherto unrecognized crustal segment (accretionary complex) that...

Evaluation of the sensitizing potential of food proteins using two mouse models

The current methodology to identify allergenic food proteins is effective in identifying those that are likely to cross-react with known allergens. However, most assays show false positive results for low/non-allergens. Therefore, an ex vivo/in vitro DC-T cell assay and an in vivo mouse model were used to distinguish known allergenic food...

Current challenges facing the assessment of the allergenic capacity of food allergens in animal models

Food allergy is a major health problem of increasing concern. The insufficiency of protein sources for human nutrition in a world with a growing population is also a significant problem. The introduction of new protein sources into the diet, such as newly developed innovative foods or foods produced using new technologies and production...

Continental breakup and the dynamics of rifting in back-arc basins: the Gulf of Lion margin

Deep seismic profiles and subsidence history of the Gulf of Lion margin reveal an intense stretching of the distal margin and strong postrift subsidence, despite weak extension of the onshore and shallow offshore portions of the margin. We revisit this evolution from the geological interpretation of an unpublished multichannel seismic profile...

V. Functions of S-layers

Although S-layers are being increasingly identified on Bacteria and Archaea, it is enigmatic that in most cases S-layer function continues to elude us. In a few instances, S-layers have been shown to be virulence factors on pathogens (e.g. Campylobacter fetus ssp. fetus and Aeromonas salmonicida), protective against Bdellovibrio, a depository...

A single Chip Implementation for Fast Convolution of Long Sequences

Usually, long convolutions are computed by programmable DSP boards using long FFTs. Typical operational requirements such as minimum power dissipation, minimum volume and high dynamic range/accuracy, make this solution often inefficient and even unacceptable. In this paper we present a single chip floating point solution for large convolution...

Vergelijking van twee vragenlijsten voor huisaandoeningen

Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia

In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE) polymorphism on pre-treatment plasma lipid levels and on the response to treatment with simvastatin was studied. The apoE phenotype distribution did not differ significantly between the FH group and a sample group of the...

De bruikbaarheid van de statistiek der bedrijfsongevallen voor epidemiologisch onderzoek

In dit artikel wordt ingegaan op de bruikbaarheid van de Statistiek der Bedrijfsongevallen voor het opsporen van groepen werknemers met een verhoogd ongevalsrisico en voor het verkrijgen van inzicht in aard en afioop van bedrijfsongevallen. De bruikbaarheid werd getoetst aan de hand van twee voorwaarden die betrekking hebben op de...