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- Lombardi, P. (author), Sijbrands, E.J.G. (author), Kamerling, S. (author), Smelt, A.H. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author) article 1998
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Zhao, S.P. (author), Smelt, A.H. (author), van den Maagdenberg, A.M. (author), van Tol, A. (author), Vroom, T.F. (author), Gevers Leuven, J.A. (author), Frants, R.R. (author), Havekes, L.M. (author), van der Laarse, A. (author), van 't Hooft, F.M. (author), TNO Preventie en Gezondheid (author)Using a density-gradient ultracentrifugation technique, we analyzed in detail the plasma lipoprotein profiles of 18 patients with familial dysbetalipoproteinemia (FD) who had apolipoprotein (apo) E2(Arg158-->Cys) homozygosity (the E2-158 variant, n = 6), apoE3-Leiden heterozygosity (the E3-Leiden variant, n = 6), or apoE2(Lys146-->Gln)...article 1994
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Zhao, S.P. (author), Smelt, A.H. (author), Gevers Leuven, J.A. (author), van den Maagdenberg, A.M. (author), van der Laarse, A. (author), van 't Hooft, F.N. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Patients with familial dysbetalipoproteinemia (FD) associated with the apo E2/2 phenotype exhibit a marked interindividual variability in serum cholesterol and triglyceride concentrations. It has been proposed that this variability is due to a combination of the apo E2/2 phenotype and additional genetic factors implicated in diseases like...article 1993