Searched for: author:"Slomp, J."
(1 - 7 of 7)
document
Quax, P.H.A. (author), Lamfers, M.L.M. (author), Lardenoye, J.H.P. (author), Grimbergen, J.M. (author), de Vries, M.R. (author), Slomp, J. (author), de Ruiter, M.C. (author), Kockx, M.M. (author), Verheijen, J.H. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Background - Smooth muscle cell migration, in addition to proliferation, contributes to a large extent to the neointima formed in humans after balloon angioplasty or bypass surgery. Plasminogen activator/plasmin-mediated proteolysis is an important mediator of this smooth muscle cell migration. Here, we report the construction of a novel hybrid...
article 2001
document
Wijnberg, M.J. (author), Slomp, J. (author), Verheijen, J.H. (author), Gaubius instituut TNO (author)
In this study we examined the localization of the plasminogen activation system and the matrix metalloproteinases in normal human arteries, arteries with diffuse intimal thickenings and atherosclerotic arteries. We found that MMP-1, MMP-2, MMP-3, TIMP-1 and TIMP-2 did not stain differently in normal arteries, arteries with intimal thickening and...
article 1999
document
Koopman, J.L. (author), Slomp, J. (author), de Bart, A.C.W. (author), Quax, P.H.A. (author), Verheijent, J.H. (author), Gaubius Instituut TNO (author)
The structural and functional properties of the urokinase-type plasminogen activator (u-PA) that are involved in the mitogenic effect of this proteolytic enzyme on human melanoma cells M14 and IF6 and the role of the u-PA receptor (u-PAR) in transducing this signal were analyzed. Native u- PA purified from urine induced a mitogenic response in...
article 1998
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Slomp, J. (author), de Gittenberger - Groot, A.C. (author), van Munsteren, J.C. (author), Huysmans, H.A. (author), van Bockel, J.H. (author), van Hinsbergh, V.W.M. (author), Poelmann, R.E. (author), Gaubius Instituut TNO (author)
Intimal proliferation is a characteristic feature of arteriosclerosis. Whole vessel wall organ culture systems have been developed to study the early stages of neointima formation. We have cultured a large number of explants of human saphenous vein specimens for several weeks, and have identified the nature of the cells in the newly formed...
article 1996
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Koopman, J.L. (author), Slomp, J. (author), de Bart, A.C.W. (author), Quax, P.H.A. (author), Verheijen, J.H. (author), TNO Preventie en gezondheid (author)
article 1996
document
Wijnberg, M.J. (author), Nieuwenbroek, N.M.E. (author), Slomp, J. (author), Quax, P.H.A. (author), Verheijen, J.H. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
The objective of this study was to investigate the role of the plasminogen activation system in the migration of human vascular smooth muscle cells in vitro. After wounding of confluent human smooth muscle cell cultures by stripping cells from their extracellular matrix, cells start to migrate from the wounded edge into the denuded area....
article 1996
document
Slomp, J. (author), Koopman, J.L. (author), Quax, P.H.A. (author), de Bart, A.C.W. (author), Hennius, B.C. (author), Nieuwenbroek, N.M.E. (author), Verheijen, J.H. (author), TNO Preventie en gezondheid (author)
abstract
article 1996
Searched for: author:"Slomp, J."
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