- document
-
van Mierlo, M.M.F. (author), Pardo, L.M. (author), Fieten, K.B. (author), van den Broek, T.J. (author), Schuren, F.H.J. (author), van Geel, M. (author), Pasmans, S.G.M.A. (author)Background: Interactions between the skin barrier, immune system, and microbiome underlie the development of atopic dermatitis (AD). Objective: To investigate the skin and nasal microbiome in relation to filaggrin gene (FLG) mutations. Methods: A cross-sectional study including 77 children with difficult-to-treat AD. The entire encoding region...article 2022
- document
-
Wiese, M. (author), Schuren, F.H.J. (author), Smits, W.K. (author), Kuijpers, E.J. (author), Ouwens, A. (author), Heerikhuisen, M. (author), Vigsnaes, L. (author), van den Broek, T.J. (author), de Boer, P. (author), Montijn, R.C. (author), Vossen, J.M.B.M. (author)Background: Clostridioides difficile is a Gram-positive anaerobic bacterium that can produce the toxins TcdA and/or TcdB and is considered an opportunistic pathogen. C. difficile is mainly transmitted as endospores, which germinate to produce the pathogenic vegetative cells under suitable conditions in the gut. To efficiently screen novel...article 2022
- document
-
Vals-Delgado, C. (author), Alcala-Diaz, J.F. (author), Molina-Abril, H. (author), Roncero-Ramos, I. (author), Caspers, M.P.M. (author), Schuren, F.H.J. (author), van den Broek, T.J. (author), Luque, R. (author), Perez-Martinez, P. (author), Katsiki, N. (author), Delgado-Lista, J. (author), Ordovas, J.M. (author), van Ommen, B. (author), Camargo, A (author), Lopez-Miranda, J. (author)Introduction: A distinctive gut microbiome have been linked to type 2 diabetes mellitus (T2DM). Objectives: We aimed to evaluate whether gut microbiota composition, in addition to clinical biomarkers, could improve the prediction of new incident cases of diabetes in patients with coronary heart disease. Methods: All the patients from the...article 2022
- document
-
Ragamin, A. (author), Fieten, K.B. (author), Tupker, R.A. (author), de Wit, J. (author), van Mierlo, M.M.F. (author), Jansen, M.S. (author), Bronner, M.B. (author), Schappin, R. (author), Schuren, F.H.J. (author), Romeijn, M.L.E. (author), Arents, B.W.M. (author), Suzanne, (author), Polinder, S. (author), de Graaf, M. (author), Rustemeyer, T. (author), Schuttelaar, M.L.A. (author), Pasmans, S.G.M.A. (author)Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 10 to 20% of children and between 2 and 15% of the adults in Western Europe. Since 2000, therapeutic clothing or functional textiles based on silver or chitosan as antibacterial agents were introduced for AD. These agents aim to reduce skin colonization with...article 2021
- document
-
Pagan, L. (author), Ederveen, R.A.M. (author), Huisman, B.W. (author), Schoones, J.W. (author), Zwittink, R.D. (author), Schuren, F.H.J. (author), Rissmann, R. (author), Piek, J.M.J. (author), van Poelgeest, M.I.E. (author)The link between cancer and the microbiome is a fast-moving field in research. There is little knowledge on the microbiome in ((pre)malignant) conditions of the vulvar skin. This systematic review aims to provide an overview of the literature regarding the microbiome composition of the healthy vulvar skin and in (pre)malignant vulvar disease....article 2021
- document
-
Steinert, R.E. (author), Rehman, A. (author), Souto Lima, E.J. (author), Agamennone, V. (author), Schuren, F.H.J. (author), Gero, D. (author), Schreiner, P. (author), Vonlanthen, R. (author), Ismaeil, A. (author), Tzafos, S. (author), Hosa, H. (author), Vetter, D. (author), Misselwitz, B. (author), Bueter, M. (author)The Roux-en-Y gastric bypass (RYGB) remains the most effective treatment for morbidly obese patients to lower body weight and improve glycemic control. There is recent evidence that the mycobiome (fungal microbiome) can aggravate disease severity in a number of diseases including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS)...article 2020
- document
-
Tott, J.E.E. (author), Pardo, L.M. (author), Fieten, K.B. (author), Vos, M.C. (author), van den Broek, T.J. (author), Schuren, F.H.J. (author), Pasmans, S.G.M.A. (author)Background: Alterations of the skin microbiome have been associated with atopic dermatitis (AD) and its severity. The nasal microbiome in relation to AD severity is less well studied. Objectives: We aimed to characterize the nasal and skin microbiomes in children with AD in relation to disease severity. In addition, we explored the differences...article 2019
- document
-
van Mierlo, M.M.F. (author), Totté, J.E.E. (author), Fieten, K.B. (author), van den Broek, T.J. (author), Schuren, F.H.J. (author), Pardo, L.M. (author), Pasmans, S.G.M.A. (author)Background: The skin microbiome, characterized by an overgrowth of Staphylococcus aureus, plays an important role in the pathogenesis of atopic dermatitis (AD). Multidisciplinary treatment in alpine climate is known for its positive effect on disease severity in children with AD and can result in a different immune response compared with...article 2019
- document
-
Perdijk, O. (author), Baarlen, P.V. (author), Fernandez-Gutierrez, M.M. (author), Brink, E.V. (author), Schuren, F.H.J. (author), Brugman, S. (author), Savelkoul, H.F.J. (author), Kleerebezem, M. (author), Neerven, R.J.J.V. (author)Human milk oligosaccharides (HMO) and prebiotic oligosaccharides are proposed to confer several health benefits to the infant. They shape the microbiota, have anti-inflammatory properties, and support epithelial barrier functioning. However, in order to select the best oligosaccharides for inclusion in infant formulas, there is a need to...article 2019
- document
-
Botschuijver, S. (author), van Diest, S.A. (author), van Thiel, I.A.M. (author), Saia, R.S. (author), Strik, A.S. (author), Yu, Z. (author), Maria-Ferreira, D. (author), Welting, O. (author), Keszthelyi, D. (author), Jennings, G. (author), Heinsbroek, S.E.M. (author), Elferink, R.P.O. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), van den Wijngaard, R.M. (author)Irritable bowel syndrome (IBS) is a heterogenic, functional gastrointestinal disorder of the gut-brain axis characterized by altered bowel habit and abdominal pain. Preclinical and clinical results suggested that, in part of these patients, pain may result from fungal induced release of mast cell derived histamine, subsequent activation of...article 2019
- document
-
van de Steeg, E. (author), Schuren, F.H.J. (author), Nooijen, I.H.G. (author), Erpelinck, S. (author), Scott Obach, R. (author), Vaes, W.H.J. (author)Gut microbiota plays a major role in metabolizing xenobiotics into active, inactive or toxic metabolites, thereby influencing pharmacokinetics, efficacy and toxicity profiles of prescribed drugs, which is currently being underexplored.public lecture 2019
- document
-
de Wit, J. (author), Totté, J.E.E. (author), van Mierlo, M.M.F. (author), van Veldhuizen, J. (author), van Doorn, M.B.A. (author), Schuren, F.H.J. (author), Willemsen, S.P. (author), Pardo, L.M. (author), Pasmans, S.G.M.A. (author)Letter to the editor. Staphylococcus aureus density is increased in many patients with atopic dermatitis (AD) and is thought to contribute to disease pathogenesis, interacting with an altered skin barrier and immunologic changes.1 S aureus might induce or aggravate inflammation through different mechanisms, for example through excretion of...article 2019
- document
-
van de Steeg, E. (author), Schuren, F.H.J. (author), Obach, R.S. (author), van Woudenbergh, C. (author), Walker, G.S. (author), Heerikhuisen, M. (author), Nooijen, I.H.G. (author), Vaes, W.H.J. (author)Colon microbiota-based drug metabolism has received little attention thus far in the process of drug development, whereas the role of gut microbiota in clinical safety and efficacy of drugs has become more clear. Many of these studies have been performed using animal studies, but the translational value of these data with respect to drug...article 2018
- document
-
Fieten, K.B. (author), Totté, J.E.E. (author), Levin, E. (author), Reyman, M. (author), Meijer, Y. (author), Schuren, F.H.J. (author), Pasmans, S.G.M.A. (author), Pasmans, S.G.M.A. (author)Background: Exposure to microbes may be important in the development of atopic disease. Atopic diseases have been associated with specific characteristics of the intestinal microbiome. The link between intestinal microbiota and food allergy has rarely been studied, and the gold standard for diagnosing food allergy (double-blind placebo...article 2018
- document
-
Fehlbaum, S. (author), Prudence, K. (author), Kieboom, J. (author), Heerikhuisen, M. (author), van den Broek, T. (author), Schuren, F.H.J. (author), Steinert, R.E. (author), Raederstorff, D. (author)Recently, the concept of prebiotics has been revisited to expand beyond non-digestible oligosaccharides, and the requirements for selective stimulation were extended to include microbial groups other than, and additional to, bifidobacteria and lactobacilli. Here, the gut microbiota-modulating effects of well-known and novel prebiotics were...article 2018
- document
-
Botschuijver, S. (author), Welting, O. (author), Levin, E. (author), Maria-Ferreira, D. (author), Koch, E. (author), Montijn, R.C. (author), Seppen, J. (author), Hakvoort, T.B.M. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), van den Wijngaard, R.M. (author)Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder associated with altered gastrointestinal microflora and increased nociception to colonic distension. This visceral hypersensitivity can be reversed in our rat maternal separation model by fungicides. Menthacarin® is a proprietary combination of essential oils from...article 2018
- document
-
Botschuijver, S. (author), Roeselers, G. (author), Levin, E. (author), Jonkers, D.M. (author), Welting, O. (author), Heinsbroek, S.E.M. (author), de Weerd, H.H. (author), Boekhout, T. (author), Fornai, M. (author), Masclee, A.A. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), Seppen, J. (author), van den Wijngaard, R.M. (author)Background & Aims Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in the activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the fungal microbiome) in the development of IBS. We analyzed intestinal mycobiomes of patients with...article 2017
- document
-
Dols, J.A.M. (author), Molenaar, D. (author), van der Helm, J.J. (author), Caspers, M.P.M. (author), de Kat Angelino-Bart, A. (author), Schuren, F.H.J. (author), Speksnijder, A.G.C.L. (author), Westerhoff, H.V. (author), Richardus, J.H. (author), Boon, M.E. (author), Reid, G. (author), de Vries, H.J.C. (author), Kort, R. (author)Background: To date, women are most often diagnosed with bacterial vaginosis (BV) using microscopy based Nugent scoring or Amsel criteria. However, the accuracy is less than optimal. The aim of the present study was to confirm the identity of known BV-associated composition profiles and evaluate indicators for BV using three molecular methods....article 2016
- document
-
Ladirat, S.E. (author), Schols, H.A. (author), Nauta, A. (author), Schoterman, M.H.C. (author), Schuren, F.H.J. (author), Gruppen, H. (author)In order to elaborate on the impact of amoxicillin treatment on the in vitro fermentation of specific structures of galacto-oligosaccharides (GOS), GOS was fractionated based on its degree of polymerization (DP) and the fermentation of individual DPs was studied. Different DP fractions of GOS and different isomeric structure within a DP fraction...article 2014
- document
-
Ladirat, S.E. (author), Schuren, F.H.J. (author), Schoterman, M.H.C. (author), Nauta, A. (author), Gruppen, H. (author), Schols, H.A. (author)Prebiotics are considered to have potential to reduce disturbances in the gut microbiota induced by antibiotics. Results in literature are, however, not consistent. The current in vitro study conducted in a fermentation screening platform allowed to unambiguously compare the impact of galacto-oligosaccharides (GOS) on adult gut microbiota...article 2014