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Santonen, T. (author), Mahiout, S. (author), Alvito, P. (author), Apel, P. (author), Bessems, J. (author), Bil, W. (author), Borges, T. (author), Bose-O'Reilly, S. (author), Buekers, J. (author), Canas Portilla, A.I. (author), Calvo, A.C. (author), de Alba González, M. (author), Dominguez-Morueco, N. (author), Lopez, M.E. (author), Falnoga, I. (author), Gerofke, A. (author), Caballero, M.D.C.G. (author), Horvat, M. (author), Huuskonen, P. (author), Kadikis, N. (author), Kolossa-Gehring, M. (author), Lange, R. (author), Louro, H. (author), Martins, C. (author), Meslin, M. (author), Niemann, L. (author), Diaz, S.P. (author), Plichta, V. (author), Porras, S.P. (author), Rousselle, C. (author), Scholten, B. (author), Silva, M.J. (author), Šlejkovec, Z. (author), Tratnik, J.S. (author), Joksic, A.Š. (author), Tarazona, J.V. (author), Uhl, M. (author), van Nieuwenhuyse, A. (author), Viegas, S. (author), Vinggaard, A.M. (author), Woutersen, M. (author), Schoeters, G. (author)One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge...article 2023
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Scholten, B. (author), Westerhout, J. (author), Pronk, A. (author), Stierum, R. (author), Vlaanderen, J. (author), Vermeulen, R. (author), Jones, K. (author), Santonen, T. (author), Portengen, L. (author)Diisocyanates are highly reactive substances and known causes of occupational asthma. Exposure occurs mainly in the occupational setting and can be assessed through biomonitoring which accounts for inhalation and dermal exposure and potential effects of protective equipment. However the interpretation of biomonitoring data can be challenging for...article 2023
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Huuskonen, P. (author), Karakitsios, S. (author), Scholten, B. (author), Westerhout, J. (author), Sarigiannis, D.A. (author), Santonen, T. (author)The aim of this work was to demonstrate how human biomonitoring (HBM) data can be used to assess cancer risks for workers and the general population. Ortho-toluidine, OT (CAS 95-53-4) is an aniline derivative which is an animal and human carcinogen and may cause methemoglobinemia. OT is used as a curing agent in epoxy resins and as intermediate...article 2022
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Jones, K. (author), Galea, K.S. (author), Scholten, B. (author), Porras, S. (author), Bousoumah, R. (author), Ndaw, S. (author), Louro, H. (author), Silva, M.J. (author), Viegas, S. (author), Godderis, L. (author), Verdonck, J. (author), Poels, K. (author), Groen, T. (author), Duca, R.C. (author), Santonen, T. (author), HBM4EU Diisocyanates Study Team, (author)Diisocyanates have long been a leading cause of occupational asthma in Europe, and recently, they have been subjected to a restriction under the REACH regulations. As part of the European Human Biomonitoring project (HBM4EU), we present a study protocol designed to assess occupational exposure to diisocyanates in five European countries. The...article 2022
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Scholten, B. (author), Laura Kenny, L. (author), Duca, R.C. (author), Pronk, A. (author), Santonen, T. (author), Galea, K.S. (author), Loh, M. (author), Huumonen, K. (author), Sleeuwenhoek, A. (author), Creta, M. (author), Godderis, L. (author), Jones, K. (author)Diisocyanates are a group of chemicals that are widely used in occupational settings. They are known to induce various health effects, including skin- and respiratory tract sensitization resulting in allergic dermatitis and asthma. Exposure to diisocyanates has been studied in the past decades by using different types of biomonitoring markers...article 2020
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Louro, H. (author), Heinälä, M. (author), Bessems, J. (author), Buekers, J. (author), Vermeire, T. (author), Woutersen, M. (author), van Engelen, J. (author), Borges, T. (author), Rousselle, C. (author), Ougier, E. (author), Alvito, P. (author), Martins, C. (author), Assunção, R. (author), Silva, M.J. (author), Pronk, A. (author), Schaddelee-Scholten, B. (author), del carmen Gonzalez, M. (author), de Alba, M. (author), Castaño, A. (author), Viegas, S. (author), Humar-Juric, T. (author), Kononenko, L. (author), Lampen, A. (author), Vinggaard, A.M. (author), Schoeters, G. (author), Kolossa-Gehring, M. (author), Santonen, T. (author)Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances may be regulated under different legislative...article 2019