Searched for: author%3A%22Ruiz-Zapata%2C+A.M.%22
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Ruiz-Zapata, A.M. (author), Heinz, A. (author), Kerkhof, M.H. (author), van de Westerlo-van Rijt, C. (author), Schmelzer, C.E.H. (author), Stoop, R. (author), Kluivers, K.B. (author), Oosterwijk, E. (author)
Fibroblast to myofibroblast differentiation is a key feature of wound-healing in soft tissues, including the vagina. Vaginal fibroblasts maintain the integrity of the vaginal wall tissues, essential to keep pelvic organs in place and avoid pelvic organ prolapse (POP). The micro-environment of vaginal tissues in POP patients is stiffer and has...
article 2020
Ruiz-Zapata, A.M. (author), Kerkhof, M.H. (author), Ghazanfari, S. (author), Zandieh-Doulabi, B. (author), Stoop, R. (author), Smit, T.H. (author), Helder, M.N. (author)
Pelvic organ prolapse (POP) is characterised by the weakening of the pelvic floor support tissues, and often by subsequent prolapse of the bladder outside the body, i.e. cystocele. The bladder is kept in place by the anterior vaginal wall which consists of a dense extracellular matrix rich in collagen content that is maintained and remodelled by...
article 2016
Kerkhof, M.H. (author), Ruiz-Zapata, A.M. (author), Bril, H. (author), Bleeker, M.C.G. (author), Belien, J.A.M. (author), Stoop, R. (author), Helder, M.N. (author)
Objective The objective of this study was to compare histological and biochemical features of the (normal) precervical anterior vaginal wall and the prolapsed anterior vaginal wall of women with pelvic organ prolapse (POP). These data were compared to tissue of the precervical anterior vaginal wall of age-matched controls without POP to identify...
article 2014