Searched for: author:"Rubingh, C.M."
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Blom, W.M. (author), Kruizinga, A.G. (author), Rubingh, C.M. (author), Remington, B.C. (author), Crevel, R.W.R. (author), Houben, G.F. (author)
Refined vegetable oils including refined peanut oil are widely used in foods. Due to shared production processes, refined non-peanut vegetable oils can contain residual peanut proteins. We estimated the predicted number of allergic reactions to residual peanut proteins using probabilistic risk assessment applied to several scenarios involving...
article 2017
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van den Broek, T.J. (author), Bakker, G.C.M. (author), Rubingh, C.M. (author), Bijlsma, S. (author), Stroeve, J.H.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Wopereis, S. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of...
article 2017
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den Ouden, H. (author), Pellis, L. (author), Rutten, G.E.H.M. (author), Geerars-van Vonderen, I.K. (author), Rubingh, C.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Beulens, J.W.J. (author)
We aimed to identify metabolites to predict patients’ response to glucose lowering treatment during the first 5 years after detection of type 2 diabetes. Metabolites were measured by GC–MS in baseline samples from 346 screen-detected type 2 diabetes patients in the ADDITION-NL study. The response to treatment with metformin and/or sulphonylurea ...
article 2016
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Goldbohm, R.A. (author), Rubingh, C.M. (author), Lanting, C.L. (author), Joosten, K.F.M. (author)
The diet of young children is an important determinant of long-term health effects, such as overweight and obesity. We analyzed two-day food consumption records from 1526 young children (10–48 months old) attending 199 daycare centers across The Netherlands. Data were observed and recorded in diaries by caregivers at the day nursery and by...
article 2016
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Klemans, R.J.B. (author), Blom, W.M. (author), van Erp, F.C. (author), Masthoff, L.J.N. (author), Rubingh, C.M. (author), van der Ent, C.K. (author), Bruijnzeel-Koomen, C.A.F.M. (author), Houben, G.F. (author), Pasmans, S.G.M.A. (author), Meijer, Y. (author), Knulst, A.C. (author)
Background: To improve food labelling strategies, information regarding eliciting doses (EDs) and the effect of patient characteristics on these EDs is necessary. Objective: To establish EDs for objective and subjective symptoms and analyse the effect of sensitization levels and other patient characteristics on threshold distribution curves ...
article 2015
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van Schalkwijk, D.B. (author), Pasman, W.J. (author), Hendriks, H.F.J. (author), Verheij, E.R. (author), Rubingh, C.M. (author), van Bochove, K. (author), Vaes, W.H.J. (author), Adiels, M. (author), Freidig, A.P. (author), de Graaf, A.A. (author)
Dietary medium chain fatty acids (MCFA) and linoleic acid follow different metabolic routes, and linoleic acid activates PPAR receptors. Both these mechanisms may modify lipoprotein and fatty acid metabolism after dietary intervention. Our objective was to investigate how dietary MCFA and linoleic acid supplementation and body fat distribution...
article 2014
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Klein Entink, R.H. (author), Remington, B.C. (author), Blom, W.M. (author), Rubingh, C.M. (author), Kruizinga, A.G. (author), Baumert, J.L. (author), Taylor, S.L. (author), Houben, G.F. (author)
For most allergenic foods, limited availability of threshold dose information within the population restricts the advice on action levels of unintended allergenic foods which should trigger advisory labeling on packaged foods.The objective of this paper is to provide guidance for selecting an optimal sample size for threshold dosing studies for...
article 2014
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Rubingh, C.M. (author), Martens, H. (author), van der Voet, H. (author), Smilde, A.K. (author)
Each data-driven action in data modelling consumes degrees of freedom, whether it concerns estimation of parameters, estimation of meta-parameters or selecting variables. By using a double cross validation approach for degrees of freedom calculation the costs for meta-parameter estimation and variable selection can be determined explicitly. The...
article 2013
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Schoen, E.D. (author), Rubingh, C.M. (author), Wopereis, S. (author), van Erk, M. (author)
Background: The False Discovery Rate (FDR) controls the expected number of false positives among the positive test results. It is not straightforward how to conduct a FDR controlling procedure in experiments with a factorial structure, while at the same time there are between-subjects and within-subjects factors. This is because there are P...
article 2013
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Bouwman, J. (author), Vogels, J.T.W.E. (author), Wopereis, S. (author), Rubingh, C.M. (author), Bijlsma, S. (author), van Ommen, B. (author)
Background: Being able to visualize multivariate biological treatment effects can be insightful. However the axes in visualizations are often solely defined by variation and thus have no biological meaning. This makes the effects of treatment difficult to interpret. Methods: A statistical visualization method is presented, which analyses and...
article 2012
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Wortelboer, H.M. (author), Bijlsma, S. (author), Rubingh, C.M. (author), Meijerink, J. (author), Witkamp, R.F. (author)
It is well established that dietary intake of n-3 fatty acids is associated with anti-inflammatory effects, and this has been linked to modulation of the oxylipin and endocannabinoid metabolomes. However, the amount of data on specific tissue effects is limited, and it is not known how inflammation affects this relation. In the present study we...
article 2012
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Willemsz, T.A. (author), Hooijmaijers, R. (author), Rubingh, C.M. (author), Frijlink, H.W. (author), Vromans, H. (author), van der Voort Maarschalk, K. (author)
Transferring processes between different scales and types of mixers is a common operation in industry. Challenges within this operation include the existence of considerable differences in blending conditions between mixer scales and types. Obtaining the correct blending conditions is crucial for the ability to break up agglomerates in order to...
article 2012
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Willemsz, T.A. (author), Hooijmaijers, R. (author), Rubingh, C.M. (author), Tran, T.N. (author), Frijlink, H.W. (author), Vromans, H. (author), Maarschalk, K.V.D.V. (author)
Problems related to the blending of a cohesive powder with a free flowing bulk powder are frequently encountered in the pharmaceutical industry. The cohesive powder often forms lumps or agglomerates which are not dispersed during the mixing process and are therefore detrimental to blend uniformity. Achieving sufficient blend uniformity requires...
article 2012
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Meijerink, J. (author), Bijlsma, S. (author), Rubingh, C.M. (author), Wortelboer, H.M. (author), Witkamp, R.F. (author)
Eicosanoids and endocannabinoids/N-acylethanolamines (NAEs) are fatty acid derived compounds with a regulatory role in inflammation. Considering their complex metabolism, it is likely that inflammation affects multiple compounds at the same time, but how lipid profiles change in plasma and other tissues after an inflammatory stimulus has not...
article 2012
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Pellis, L. (author), van Erk, M.J. (author), van Ommen, B. (author), Bakker, G.C.M. (author), Hendriks, H.F.J. (author), Cnubben, N.H.P. (author), Kleemann, R. (author), van Someren, E.P. (author), Bobeldijk, I. (author), Rubingh, C.M. (author), Wopereis, S. (author)
We introduce the metabolomics and proteomics based Postprandial Challenge Test (PCT) to quantify the postprandial response of multiple metabolic processes in humans in a standardized manner. The PCT comprised consumption of a standardized 500 ml dairy shake containing respectively 59, 30 and 12 energy percent lipids, carbohydrates and protein....
article 2012
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Rubingh, C.M. (author), van Erk, M.J. (author), Wopereis, S. (author), van Vliet, T. (author), Verheij, E.R. (author), Cnubben, N.H.P. (author), van Ommen, B. (author), van der Greef, J. (author), Hendriks, H.F.J. (author), Smilde, A.K. (author)
Many benefits can be gained if multi-factorial diseases with a high incidence and prevalence are better understood. Sophisticated approaches like multilevel analyses are needed to discover subtle differences between healthy people and people at the onset of disease in these types of studies. Multilevel analysis generates different sub-models for...
article 2011
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Smilde, A.K. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Bijlsma, S. (author), Rubingh, C.M. (author), Vis, D.J. (author), Jellema, R.H. (author), Pijl, H. (author), Roelfsema, F. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
In metabolomics, time-resolved, dynamic or temporal data is more and more collected. The number of methods to analyze such data, however, is very limited and in most cases the dynamic nature of the data is not even taken into account. This paper reviews current methods in use for analyzing dynamic metabolomic data. Moreover, some methods from...
article 2010
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Bakker, G.C.M. (author), van Erk, M.J. (author), Pellis, L. (author), Wopereis, S. (author), Rubingh, C.M. (author), Cnubben, N.H.P. (author), Kooistra, T. (author), van Ommen, B. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Background: Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Objective: It was hypothesized that specific dietary components are able to reduce low-grade inflammation as well as metabolic and oxidative stress. Design: Dietary products [resveratrol, green tea extract, α-tocopherol,...
article 2010
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van den Berg, R.A. (author), Rubingh, C.M. (author), Westerhuis, J.A. (author), van der Werf, M.J. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)
In metabolomics research, it is often important to focus the data analysis to specific areas of interest within the metabolome. In this paper, we describe the application of consensus principal component analysis (CPCA) and canonical correlation analysis (CCA) as a means to explore the relation between metabolome data and (i) biochemically...
article 2009
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Wopereis, S. (author), de Rubingh, C.M. (author), van Erk, M.J. (author), Verheij, E.R. (author), van Vliet, T. (author), Cnubben, N.H. (author), Smilde, A.K. (author), van der Greef, J. (author), van Ommen, B. (author), Hendriks, H.F. (author), TNO Kwaliteit van Leven (author)
BACKGROUND: The prevalence of overweight is increasing globally and has become a serious health problem. Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Novel tools to understand these processes are needed. Metabolic profiling is one such tool that can provide novel insights into...
article 2009
Searched for: author:"Rubingh, C.M."
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