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Matualatupauw, J.C. (author), O'Grada, C. (author), Hughes, M.F. (author), Roche, H.M. (author), Afman, L.A. (author), Bouwman, J. (author)Scope: Several studies have examined the whole-genome gene expression response in blood cells to high-fat challenges with differing results. The study aims to identify consistently up- or downregulated genes and pathways in response to a high-fat challenge using several integration methods. Methods and results: Three studies measuring the gene...article 2019
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Brouwer-Brolsma, E.M. (author), Brennan, L. (author), Drevon, C.A. (author), van Kranen, H. (author), Manach, C. (author), Dragsted, L.O. (author), Roche, H.M. (author), Andres-Lacueva, C. (author), Bakker, S.J.L. (author), Bouwman, J. (author), Capozzi, F. (author), de Saeger, S. (author), Gundersen, T.E. (author), Kolehmainen, M. (author), Kulling, S.E. (author), Landberg, R. (author), Linseisen, J. (author), Mattivi, F. (author), Mensink, R.P. (author), Scaccini, C. (author), Skurk, T. (author), Tetens, I. (author), Vergeres, G. (author), Wishart, D.S. (author), Scalbert, A. (author), Feskens, E.J.M. (author)FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food...article 2017
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Grimaldi, K.A. (author), van Ommen, B. (author), Ordovas, J.M. (author), Parnell, L.D. (author), Mathers, J.C. (author), Bendik, I. (author), Brennan, L. (author), Celis-Morales, C. (author), Cirillo, E. (author), Daniel, H. (author), de Kok, B. (author), El-Sohemy, A. (author), Fairweather-Tait, S.J. (author), Fallaize, R. (author), Fenech, M. (author), Ferguson, L.R. (author), Gibney, E.R. (author), Gibney, M. (author), Gjelstad, I.M.F. (author), Kaput, J. (author), Karlsen, A.S. (author), Kolossa, S. (author), Lovegrove, J. (author), Macready, A.L. (author), Marsaux, C.F.M. (author), Alfredo Martinez, J. (author), Milagro, F. (author), Navas-Carretero, S. (author), Roche, H.M. (author), Saris, W.H.M. (author), Traczyk, I. (author), van Kranen, H. (author), Verschuren, L. (author), Virgili, F. (author), Weber, P. (author), Bouwman, J. (author)Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendations for dietary choices that are more...article 2017
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Minihane, A.M. (author), Vinoy, S. (author), Russell, W.R. (author), Baka, A. (author), Roche, H.M. (author), Tuohy, K.M. (author), Teeling, J.L. (author), Blaak, E.E. (author), Fenech, M. (author), Vauzour, D. (author), McArdle, H.J. (author), Kremer, B.H.A. (author), Sterkman, L. (author), Vafeiadou, K. (author), Benedetti, M.M. (author), Williams, C.M. (author), Calder, P.C. (author)The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's...article 2015
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Morine, M.J. (author), Tierney, A.C. (author), van Ommen, B. (author), Daniel, H. (author), Toomey, S. (author), Gjelstad, I.M.F. (author), Gormley, I.C. (author), Pérez-Martinez, P. (author), Drevon, C.A. (author), López-Miranda, J. (author), Roche, H.M. (author)Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to pathway analysis, we have developed a joint multivariate and network-based approach to analysis of a dataset of habitual dietary records, adipose tissue transcriptomics and comprehensive plasma marker profiles from human...article 2011
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- TNO Kwaliteit van Leven (author), Baccini, M. (author), Bachmaier, E.M. (author), Biggeri, A. (author), Boekschoten, M.V. (author), Bouwman, F.G. (author), Brennan, L. (author), Caesar, R. (author), Cinti, S. (author), Coort, S.L. (author), Crosley, K. (author), Daniel, H. (author), Drevon, C.A. (author), Duthie, S. (author), Eijssen, L. (author), Elliott, R.M. (author), van Erk, M. (author), Evelo, C. (author), Gibney, M. (author), Heim, C. (author), Horgan, G.W. (author), Johnson, I.T. (author), Kelder, T. (author), Kleemann, R. (author), Kooistra, T. (author), van Iersel, M.P. (author), Mariman, E.C. (author), Mayer, C. (author), McLoughlin, G. (author), Müller, M. (author), Mulholland, F. (author), van Ommen, B. (author), Polley, A.C. (author), Pujos-Guillot, E. (author), Rubio-Aliaga, I. (author), Roche, H.M. (author), de Roos, B. (author), Sailer, M. (author), Tonini, G. (author), Williams, L.M. (author), de Wit, N. (author) article 2008
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TNO Kwaliteit van Leven (author), van Ommen, B. (author), Cavallieri, D. (author), Roche, H.M. (author), Klein, U.I. (author), Daniel, H. (author)Nutritional systems biology may be defined as the ultimate goal of molecular nutrition research, where all relevant aspects of regulation of metabolism in health and disease states at all levels of its complexity are taken into account to describe the molecular physiology of nutritional processes. The complexity spans from intracellular to inter...article 2008
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- Gibney, M.J. (author), Walsh, M. (author), Brennan, L. (author), Roche, H.M. (author), German, B. (author), van Ommen, B. (author), TNO Kwaliteit van Leven (author) article 2005
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TNO Kwaliteit van Leven TNO Voeding (author), Gibney, M.J. (author), Walsh, M. (author), Brennan, L. (author), Roche, H.M. (author), German, B. (author), van Ommen, B. (author)Metabolomics has been widely adopted in pharmacology and toxicology but is relatively new in human nutrition. The ultimate goal, to understand the effects of exogenous compounds on human metabolic regulation, is similar in all 3 fields. However, the application of metabolomics to nutritional research will be met with unique challenges. Little is...article 2005