Search results | TNO Publications

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Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYPIA, CYP2B and CYP4A forms in precision-cut rat liver slices

Pan, J. (author), Xiang, Q. (author), Renwick, A.B. (author), Price, R.J. (author), Ball, S.E. (author), Kao, J. (author), Scatina, J.A. (author), Lake, B.G. (author), TNO Voeding (author)

article 2002

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Inhibition of zaleplon metabolism by cimetidine in the human liver: In vitro studies with subcellular fractions and precision-cut liver slices

Renwick, A.B. (author), Ball, S.E. (author), Tredger, J.M. (author), Price, R.J. (author), Walters, D.G. (author), Kao, J. (author), Scatina, J.A. (author), Lake, B.G. (author), TNO Voeding (author)

The effect of cimetidine on the metabolism of zaleplon (ZAL) in human liver subcellular fractions and precision-cut liver slices was investigated. 2. ZAL was metabolized to a number of products including 5-oxo-ZAL (M2), which is known to be formed by aldehyde oxidase, N-desethyl-ZAL (DZAL), which is known to be formed by CYP3A forms, and N...

article 2002

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Metabolism of a novel phosphodiesterase-IV inhibitor (V11294) by human hepatic cytochrome P450 forms

Subrahmanyam, V. (author), Renwick, A.B. (author), Waters, D.G. (author), Price, R.J. (author), Tonelli, A.P. (author), Lake, B.G. (author), TNO Voeding (author)

article 2002

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Metabolism of zaleplon by human liver: Evidence for involvement of aldehyde oxidase

Lake, B.G. (author), Ball, S.E. (author), Kao, J. (author), Renwick, A.B. (author), Price, R.J. (author), Scatina, J.A. (author), TNO Voeding (author)

article 2002

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Lack of effect of furfural on unscheduled DNA synthesis in the in vivo rat and mouse hepatocyte DNA repair assays and in precision-cut human liver slices

Lake, B.G. (author), Edwards, A.J. (author), Price, R.J. (author), Phillips, B.J. (author), Renwick, A.B. (author), Beamand, J.A. (author), Adams, T.B. (author), TNO Voeding (author)

article 2001

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Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethyl- coumarin by human hepatic CYP isoforms: Evidence for selectivity towards CYP3A4

Renwick, A.B. (author), Lewis, D.F.V. (author), Fulfords, S. (author), Surry, D. (author), Williams, B. (author), Worboys, P.D. (author), Cai, X. (author), Wang, R.W. (author), Price, R.J. (author), Lake, B.G. (author), Evans, D.C. (author), TNO Voeding (author)

article 2001

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Carbamazapine: A 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems

Pelkonen, O. (author), Myllynen, P. (author), Taavitsainen, P. (author), Boobis, A.R. (author), Watts, P. (author), Lake, B.G. (author), Price, R.J. (author), Renwick, A.B. (author), Gómez-Lechón, M.J. (author), Castell, J.V. (author), Ingelman-Sundberg, M. (author), Hidestrand, M. (author), Guillouzo, A. (author), Corcos, L. (author), Goldfarb, P.S. (author), Lewis, D.F.V. (author), TNO Voeding (author)

article 2001

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Evaluation of 7-benzyloxy-4-trifluoromethyl-coumarin, some other 7-hydroxy-4-trifluoro-methylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes

Renwick, A.B. (author), Lavignette, G. (author), Worboys, P.D. (author), Williams, B. (author), Surry, D. (author), Lewis, D.F.V. (author), Price, R.J. (author), Lake, B.G. (author), Evans, D.C. (author), TNO Voeding (author)

article 2001

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Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

Subrahmanyam, V. (author), Renwick, A.B. (author), Walters, D.G. (author), Young, P.J. (author), Price, R.J. (author), Tonelli, A.P. (author), Lake, B.G. (author), TNO Voeding (author)

article 2001

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An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant

Andersson, T.B. (author), Sjöberg, H. (author), Hoffmann, K.J. (author), Boobis, A.R. (author), Watts, P. (author), Edwards, R.J. (author), Lake, B.G. (author), Price, R.J. (author), Renwick, A.B. (author), Gómez-Lechón, M.J. (author), Castell, J.V. (author), Ingelman-Sundberg, M. (author), Hidestrand, M. (author), Goldfarb, P.S. (author), Lewis, D.F.V. (author), Corcos, L. (author), Guillouzo, A. (author), Taavitsainen, P. (author), Pelkonen, O. (author), TNO Voeding (author)

article 2001

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Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms

Renwick, A.B. (author), Surry, D. (author), Price, R.J. (author), Lake, B.G. (author), Evans, D.C. (author)

article 2000

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Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices

Renwick, A.B. (author), Watts, P.S. (author), Edwards, R.J. (author), Barton, P.T. (author), Guyonnet, I. (author), Price, R.J. (author), Tredger, J.M. (author), Pelkonen, O. (author), Boobis, A.R. (author), Lake, B.G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)

The maintenance of the major hepatic cytochrome P450 (CYP) enzymes has been studied in precision-cut human liver slices cultured for up to 72 h in supplemented RPMI 1640 medium. The relative apoprotein levels of 11 CYP enzymes were determined using a panel of antipeptide antibodes. In addition, 7-ethoxyresorufin O-deethylase, tolbutamide...

article 2000

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Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices

Renwick, A.B. (author), Watts, P.S. (author), Edwards, R.J. (author), Barton, P.T. (author), Guyonnet, I. (author), Price, R.J. (author), Tredger, J.M. (author), Pelkonen, O. (author), Boobis, A.R. (author), Lake, B.G. (author)

article 2000

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CYP isoform induction screening in 96-well plates: Use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes

Price, R.J. (author), Surry, D. (author), Renwick, A.B. (author), Meneses-Lorente, G. (author), Lake, B.G. (author), Evans, D.C. (author)

article 2000

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Lack of effect of coumarin on unscheduled DNA synthesis in the in vivo rat hepatocyte DNA repair assay

Edwards, A.J. (author), Price, R.J. (author), Renwick, A.B. (author), Lake, B.G. (author), TNO BIBRA TNO Kwaliteit van Leven (author)

The ability of coumarin to induce UDS in male Sprague-Dawley CD rat hepatocytes in vivo was assessed using the unscheduled DNA synthesis (UDS) assay. From a preliminary toxicity study the oral maximum tolerated dose (MTD) of coumarin was determined to be 320mg/kg body weight. For the UDS studies, rats were treated with 0 (corn oil control), 32 ...

article 2000