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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.P.H.T.M. (author), Horbach, G.J. (author), Smit, M.J. (author), Zandberg, P. (author), Mellema, J.R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were administered at five single oral dosages between 2 and 500 mg/kg and between 6 and 1800 mg/kg,...article 2007
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Ploemen, J.P.H.T.M. (author), Kelder, J. (author), Hafmans, T. (author), van de Sandt, H. (author), van Burgsteden, J.A. (author), Salemink, P.J.M. (author), van Esch, E. (author), TNO Voeding (author)Several cationic amphiphilic compounds are known to induce phospholipidosis, a condition primarily characterized by excessive accumulation of phospholipids in different cell types, giving the affected cells a finely foamy appearance. Excessive storage of lamellar membranous intralysosomal inclusion bodies is the hallmark for phospholipidosis on...article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Ploemen, J.P.H.T.M. (author), Wormhoudt, L.W. (author), Haenen, G.R.M.M. (author), Oudshoorn, M.J. (author), Commandeur, J.N.M. (author), Vermeulen, N.P.E. (author), de Waziers, I. (author), Beaune, P.H. (author), Watabe, T. (author), van Bladeren, P.J. (author)Ethylene dibromide (1,2-dibromoethane, EDB) is metabolized by two routes: a conjugative route catalyzed by glutathione S-transferases (GST) and an oxidative route catalyzed by cytochrome P450 (P450). The GST route is associated with carcinogenicity. An approach is presented to use human purified GST and P450 enzymes to explore the importance of...article 1997
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- Ploemen, J.P.H.T.M. (author), van Ommen, B. (author), van Iersel, M.L.P.S. (author), Rompelberg, C.J.M. (author), Verhagen, H. (author), van Bladeren, P.J. (author), TNO Voeding (author) article 1996
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van Iersel, M.L.P.S. (author), Ploemen, J.P.H.T.M. (author), Struik, I. (author), van Amersfoort, C. (author), Keyzer, A.E. (author), Schefferlie, J.G. (author), van Bladeren, P.J. (author), TNO Voeding (author)The glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene in intact human IGR-39 melanoma cells was determined by the quantification by HPLC-analysis of the excreted glutathione (GSH) conjugate (S-(2,4-dinitrophenyl)glutathione; DNPSG). The major GST subunit expressed in these melanoma cells is the π-class GST subunit P1....article 1996