Searched for: author:"Pijl, H."
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Molema, H. (author), van Erk, M. (author), van Ommen, B. (author), Pijl, H. (author), Wopereis, S. (author), Kiefte-de Jong, J. (author), Chavannes, N. (author), Kremer, B. (author), van Bilsen, J. (author), van Winkelhof, M. (author)
Op dit moment is sprake van een COVID-19-pandemie met grote persoonlijke, medische, maatschappelijke en financieel-economische schade. Landen en zorgsystemen gaan tot het uiterste om de COVID-19-uitbraak het hoofd te bieden. In Nederland kunnen we daarbij bouwen op een zeer goed zorgsysteem, zowel in de intensieve zorg (intensive care,...
report 2020
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Molema, H. (author), van Erk, M. (author), van Winkelhof, M. (author), van 't Land, K. (author), Kiefte-de Jong, J. (author), van Ommen, B. (author), Pijl, H. (author), Cahn, W. (author), Deenik, J. (author), Maljaars, J. (author), van der Boog, P. (author), van Laarhoven, K. (author), de Reuver, P. (author), van Rossum, L. (author), Hoenders, R. (author), van Schaardenburg, D. (author), Wopereis, S. (author), Bonten, T. (author), Vos, R. (author), Navis, G. (author), Olde Rikkert, M. (author), Kraaijenhagen, R. (author), Preller, L. (author), Stronks, K. (author)
Dat leefstijl van groot belang is om gezond te zijn en te blijven, weten de meeste Nederlanders wel. Maar dat leefstijlinterventies effectief ingezet kunnen worden voor herstel of behandeling van ziekten is minder bekend. Daarom richten wij ons bij het Nederlands Innovatiecentrum voor Leefstijlgeneeskunde juist daarop, dat doen we onder de naam...
book 2019
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van Ommen, B. (author), Wopereis, S. (author), van Empelen, P. (author), van Keulen, H.M. (author), Otten, W. (author), Kasteleyn, M. (author), Molema, J.J.W. (author), de Hoogh, I.M. (author), Chavannes, N.H. (author), Numans, M.E. (author), Evers, A.W.M. (author), Pijl, H. (author)
From a biological view, most of the processes involved in insulin resistance, which drives the pathobiology of type 2 diabetes, are reversible. This theoretically makes the disease reversible and curable by changing dietary habits and physical activity, particularly when adopted early in the disease process. Yet, this is not fully implemented...
article 2018
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Guigas, B. (author), de Leeuw van Weenen, J.E. (author), van Leeuwen, N. (author), Simonis-Bik, A.M. (author), van Haeften, T.W. (author), Nijpels, G. (author), Houwing-Duistermaat, J.J. (author), Beekman, M. (author), Deelen, J. (author), Havekes, L.M. (author), Penninx, B.W.J.H. (author), Vogelzangs, N. (author), van 't Riet, E. (author), Dehghan, A. (author), Hofman, A. (author), Witteman, J.C. (author), Uitterlinden, A.G. (author), Grarup, N. (author), Jørgensen, T. (author), Witte, D.R. (author), Lauritzen, T. (author), Hansen, T. (author), Pedersen, O. (author), Hottenga, J. (author), Romijn, J.A. (author), Diamant, M. (author), Kramer, M.H.H. (author), Heine, R.J. (author), Willemsen, G. (author), Dekker, J.M. (author), Eekhoff, E.M. (author), Pijl, H. (author), de Geus, E.J. (author), Slagboom, P.E. (author), 't Hart, L.M. (author)
Aims: Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic β-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to Type 2 diabetes in humans. Methods: Four potentially functional variants in the coding region of the DRD2...
article 2014
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Klein-Wieringa, I.R. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Giera, M. (author), de Lange-Brokaar, B.J. (author), van Osch, G.J. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Pijl, H. (author), Huizinga, T.W. (author), Kloppenburg, M. (author), Toes, R.E. (author), Ioan-Facsinay, A. (author)
Previous studies have shown accumulation and an enhanced proinflammatory profile of macrophages in adipose tissue of obese mice, indicating the presence of an interaction between adipocytes and macrophages in this tissue. However, the consequences of this interaction in humans are yet incompletely understood. In this study, we explored the...
article 2013
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Coomans, C.P. (author), Geerling, J.J. (author), van den Berg, S.A.A. (author), van Diepen, H.C. (author), Garcia-Tardõn, N. (author), Thomas, A. (author), Schröder-Van Der Elst, J.P. (author), Ouwens, D.M. (author), Pijl, H. (author), Rensen, P.C.N. (author), Havekes, L.M. (author), Guigas, B. (author), Romijn, J.A. (author)
Background and Purpose Topiramate improves insulin sensitivity, in addition to its antiepileptic action. However, the underlying mechanism is unknown. Therefore, the present study was aimed at investigating the mechanism of the insulin-sensitizing effect of topiramate both in vivo and in vitro. Experimental Approach Male C57Bl/6J mice were fed a...
article 2013
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Auvinen, H.E. (author), Romijn, J.A. (author), Biermasz, N.R. (author), Pijl, H. (author), Havekes, L.M. (author), Smit, J.W.A. (author), Rensen, P.C.N. (author), Pereira, A.M. (author)
Alterations in hypothalamus-pituitary-adrenal (HPA) axis activity have been linked to the development of the metabolic syndrome (MetS). Common features of the MetS, like insulin resistance and obesity, are reproducibly induced by high fat diet (HFD) in animal models of diet-induced obesity. These models, hampered by methodological differences,...
article 2012
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Parlevliet, E.T. (author), Wang, Y. (author), Geerling, J.J. (author), Schröder-Van der Elst, J.P. (author), Picha, K. (author), O'Neil, K. (author), Stojanovic-Susulic, V. (author), Ort, T. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), Rensen, P.C.N. (author)
Objective: In addition to improve glucose intolerance, recent studies suggest that glucagon-like peptide-1 (GLP-1) receptor agonism also decreases triglyceride (TG) levels. The aim of this study was to evaluate the effect of GLP-1 receptor agonism on very-low-density lipoprotein (VLDL)-TG production and liver TG metabolism. Experimental Approach...
article 2012
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Coomans, C.P. (author), Geerling, J.J. (author), Guigas, B. (author), van den Hoek, A.M. (author), Parlevliet, E.T. (author), Ouwens, D.M. (author), Pijl, H. (author), Voshol, P.J. (author), Rensen, P.C.N. (author), Havekes, L.M. (author), Romijn, J.A. (author), Gaubius Instituut TNO (author)
Insulin signaling in the central nervous system (CNS) is required for the inhibitory effect of insulin on glucose production. Our aim was to determine whether the CNS is also involved in the stimulatory effect of circulating insulin on the tissue-specific retention of fatty acid (FA) from plasma. In wild-type mice, hyperinsulinemic-euglycemic...
article 2011
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Snel, M. (author), Sleddering, M.A. (author), Pijl, H. (author), Nieuwenhuizen, W.F. (author), Frölich, M. (author), Havekes, L.M. (author), Romijn, J.A. (author), Jazet, I.M. (author), TNO Kwaliteit van Leven (author)
Background: Sphingolipids, like phytosphingosine (PS) are part of cellular membranes of yeasts, vegetables and fruits. Addition of PS to the diet decreases serum cholesterol and free fatty acid (FFA) levels in rodents and improves insulin sensitivity.Objective:To study the effect of dietary supplementation with PS on cholesterol and glucose...
article 2010
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Smilde, A.K. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Bijlsma, S. (author), Rubingh, C.M. (author), Vis, D.J. (author), Jellema, R.H. (author), Pijl, H. (author), Roelfsema, F. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
In metabolomics, time-resolved, dynamic or temporal data is more and more collected. The number of methods to analyze such data, however, is very limited and in most cases the dynamic nature of the data is not even taken into account. This paper reviews current methods in use for analyzing dynamic metabolomic data. Moreover, some methods from...
article 2010
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Vis, D.J. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Pijl, H. (author), Roelfsema, F. (author), van der Greef, J. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)
The detection of hormone secretion episodes is important for understanding normal and abnormal endocrine functioning, but pulse identification from hormones measured with short interval sampling is challenging. Furthermore, to obtain useable results, the model underlying hormone secretion and clearance must be augmented with restrictions based...
article 2010
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de Leeuw van Weenen, J.E. (author), Parlevliet, E.T. (author), Maechler, P. (author), Havekes, L.M. (author), Romijn, J.A. (author), Ouwens, D.M. (author), Pijl, H. (author), Guigas, B. (author), TNO Kwaliteit van Leven (author)
Treatment with the dopamine receptor D2 (DRD2) agonist bromocriptine improves metabolic features in obese patients with type 2 diabetes by a still unknown mechanism. In the present study, we investigated the acute effect of bromocriptine and its underlying mechanism(s) on insulin secretion both in vivo and in vitro. For this purpose, C57Bl6/J...
article 2010
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Parlevliet, E.T. (author), Schröder-van der Elst, J.P. (author), Corssmit, E.P.M. (author), Picha, K. (author), O'Neil, K. (author), Stojanovic-Susulic, V. (author), Ort, T. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), TNO Kwaliteit van Leven (author)
CNTO736 is a glucagon-like peptide (GLP) 1 receptor agonist that incorporates a GLP-1 peptide analog linked to the Mimeti-body platform. We evaluate the potential of acute and chronic CNTO736 treatment on insulin sensitivity and very low-density lipoprotein (VLDL) metabolism. For acute studies, diet-induced insulin-resistant C57BL76 mice...
article 2009
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Parlevliet, E.T. (author), Heijboer, A.C. (author), Schroder-van der Elst, J.P. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), Corssmit, E.P.M. (author), TNO Kwaliteit van Leven (author)
article 2008
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van den Hoek, A.M. (author), van Heijningen, C. (author), van der Schröder - Elst, J.P. (author), Ouwens, D.M. (author), Havekes, L.M. (author), Romijn, J.A. (author), Kalsbeek, A. (author), Pijl, H. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE-We recently showed that intracerebroventricular infusion of neuropeptide Y (NPY) hampers inhibition of endogenous glucose production (EGP) by insulin in mice. The down stream mechanisms responsible for these effects of NPY remain to be elucidated. Therefore, the aim of this study was to establish whether intracerebroventricular NPY...
article 2008
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Parlevliet, E.T. (author), Schröder-van der Elst, J.P. (author), Corssmit, E.P.M. (author), Picha, K. (author), O'Neil, K. (author), Stojanovic-Susulic, V. (author), Ort, T. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), TNO Kwaliteit van Leven (author)
article 2008
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van den Hoek, A.M. (author), Teusink, B. (author), Voshol, P.J. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), TNO Kwaliteit van Leven (author)
Obese humans are often insulin- and leptin resistant. Since leptin can affect glucose metabolism, it is conceivable that a lack of leptin signal transduction contributes to insulin resistance. It remains unclear whether leptin affects glucose metabolism via peripheral and/or central mechanistic routes. In the present study, we aimed: (i) to...
article 2008
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Smeets, P.A.M. (author), Vidarsdottir, S. (author), de Graaf, C. (author), Stafleu, A. (author), van Osch, M.J.P. (author), Viergever, M.A. (author), Pijl, H. (author), van der Grond, J. (author), TNO Kwaliteit van Leven (author)
We previously showed that hypothalamic neuronal activity, as measured by the blood oxygen level-dependent (BOLD) functional MRI signal, declines in response to oral glucose intake. To further explore the mechanism driving changes in hypothalamic neuronal activity in response to an oral glucose load, we here compare hypothalamic BOLD signal...
article 2007
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Heijboer, A.C. (author), van den Hoek, A.M. (author), Parlevliet, E.T. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), Corssmit, E.P.M. (author), TNO Kwaliteit van Leven (author)
Aims/hypothesis: This study was conducted to evaluate the effects of ghrelin on insulin's capacity to suppress endogenous glucose production and promote glucose disposal in mice. To establish whether the growth hormone secretagogue (GHS) receptor can mediate the putative effect of ghrelin on the action of insulin, we also determined the...
article 2006
Searched for: author:"Pijl, H."
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