Experiences of a High-Risk Population with Prenatal Hemoglobinopathy Carrier Screening in a Primary Care Setting: a Qualitative Study

Carrier screening for hemoglobinopathies (HbPs; sickle cell disease and thalassemia) aims to facilitate autonomous reproductive decision-making. In the absence of a Dutch national HbP carrier screening program, some primary care midwives offer screening on an ad hoc basis. This qualitative descriptive study explores how pregnant women perceive...

Gemiste hielprikscreening

Hemoglobinopathie in de 21e eeuw : incidentie, diagnose en hielprikscreening (Haemoglobinopathy in the 21st century: incidence, diagnosis and heel prick screening)

Objective To determine the incidence of severe haemoglobinopathy, to evaluate the effect of heel prick screening, and to identify those children who do not benefit from this early diagnosis. Design Prospective descriptive study. Method Registration of all symptomatic and asymptomatic children who between 2003-2009 were newly diagnosed with the a...

One-third of the new paediatric patients with sickle cell disease in The Netherlands are immigrants and do not benefit from neonatal screening

Objectives: To estimate the prevalence of children with sickle cell disease (SCD) in The Netherlands. To estimate the annual number of children newly diagnosed as having SCD and the proportion with diagnoses through neonatal screening To estimate the proportion of children with SCD receiving paediatric care in a comprehensive care setting....

Sikkelcelziekte in de hielscreening I: Opgespoorde kinderen in het eerste jaar

JGZ.

Sikkelcelziekte in de hielprikscreening I [Sickle cell disease in newborn screening: I. Children detected in the first year I}

Doel Evalueren van de uitkomsten van het eerste jaar na invoering van de uitbreiding van de landelijke hielprikscreening met sikkelcelziekte (SCZ). Opzet Prospectieve landelijke registratie van kinderen met vermoedelijk SCZ of een andere vorm van ernstige hemoglobinopathie. Methode De bloedspots werden geanalyseerd met een...

Kwaliteit van leven bij kinderen met sikkelcelziekte in de regio Amsterdam [Quality of life of children with sickle cell disease in the Amsterdam area]

Objective. To determine the differences in quality of life between children with sickle cell disease and healthy immigrant children. Design. Descriptive, comparative. Method. The quality of life of children with sickle cell disease between 5 and 15 years old being treated in the Emma Children's Hospital AMC in Amsterdam, the Netherlands, was...

Estrogens reduce plasma histidine-rich glycoprotein (HRG) levels in a dose-dependent way

Plasma levels of histidine-rich glycoprotein (HRG) were investigated in three groups of women receiving a different dose of estrogens. First, the effect of low-dose estrogen was studied in a group of 83 postmenopausal women who were treated with 0.625 mg conjugated estrogens (CE). No significant change from baseline levels was found at the end...

Impaired fibrinolysis in the hemolytic-uremic syndrome of childhood

Groepswerk in de confectie: beschrijving en analyse van vier bedrijven met een integraal aangepaste produktie- en arbeidsorganisatie

Als vervolg op een in 1991 door het NIPG afgeronde studie naar de sociale en organisatorische merites van een drietal op de markt verschenen nieuwe produktiesystemen is in vier Nederlandse confectiebedrijven beschreven en geanalyseerd welke organisatorische (in plaats van technische) veranderingen zij in de naaizalen (waar voornamelijk vrouwen...

Impaired fibrinolysis in haemolytic uremic syndrome of childhood (abstract)