Reservoir optimization for the synthetic brugge field

Increasing availability of data and tools for history matching and optimisation brings the long-term goal of closed loop reservoir management closer. However, still many issues are not solved. An example is the interaction between the history match of the reservoir model and the optimisation. How important is a good history match for the...

Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: Antiangiogenic properties of a new class of antitumor agents

Synthetic alkylphospholipids (APLs), such as edelfosine, miltefosine and perifosine, constitute a new class of antineoplastic compounds with various clinical applications. Here we have evaluated the antiangiogenic properties of APLs. The sensitivity of three types of vascular endothelial cells (ECs) (bovine aortic ECs, human umbilical vein ECs...

Gas coning control for smart wells using a dynamic coupled well-reservoir simulator

A strong increase in gas inflow due to gas coning and the resulting bean-back because of Gas to Oil Ratio (GOR) constraints can severely limit oil production and reservoir drive energy. In this paper we will use a coupled reservoir-well model to demonstrate that oil production can be increased by using controlled inflow from a gas cone as a...

Using a dynamic coupled well-reservoir simulator to optimize production of a horizontal well in a thin oil rim

Stabilization and optimization of production are the key challenges for smart well control. In order to compare the effectiveness of different control strategies, a simulation environment can be used. To study and control the effects of for instance slugging, gas coning and wax deposition, both reservoir dynamics and the dynamics of multi-phase...

Influence of ensemble geostatistics on production history matching and prediction at new wells

Automatic history matching techniques such as the Ensemble Kalman Filter (EnKF) have been shown to provide reliable results for matching and prediction at existing wells. It is much less clear if the prediction outside of existing wells improves as a result of history matching. The amount of information in production data on the spatial...

An investigation into the need of a dynamic coupled well-reservoir simulator

Within the research framework of the "Integrated System Approach Petroleum Production" (ISAPP) knowledge center of TNO, TU Delft and Shell, the necessity of taking the interaction between dynamic reservoir and dynamic well behavior into account when optimizing a producing asset is investigated. To simulate dynamic phenomena in the well and in...

CD34+ cells home, proliferate, and participate in capillary formation, and in combination with CD34- cells enhance tube formation in a 3-dimensional matrix

Objective - Emerging evidence suggests that human blood contains bone marrow (BM)-derived endothelial progenitor cells that contribute to postnatal neovascularization. Clinical trials demonstrated that administration of BM-cells can enhance neovascularization. Most studies, however, used crude cell populations. Identifying the role of different...

Aminopeptidase inhibitor bestatin stimulates microvascular endothelial cell invasion in a fibrin matrix

The aminopeptidase inhibitor bestatin has been shown to have anti-angiogenic effects in a number of model systems. These effects are thought to result from inhibition of CD13 activity. Because tumor angiogenesis can evolve in a fibrin-rich stroma matrix we have studied for the first time the effects of bestatin on microvascular endothelial...

Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix

Adult angiogenesis, associated with pathologic conditions, is often accompanied by the formation of a fibrinous exudate. This temporary matrix consists mainly of fibrin but is intermingled with plasma proteins and collagen fibers. The formation of capillary structures in a fibrinous matrix in vivo was mimicked by an in vitro model, in which...

Impact of apolipoprotein(a) on in vitro angiogenesis

Angiostatin, which consists of the kringle I-IV domains of plasminogen and which is secreted into urine, is an efficient inhibitor of angiogenesis and tumor growth. Because N-terminal apolipoprotein(a) [apo(a)] fragments, which also contain several types of kringle IV domains, are found in urine as well, we evaluated the potential angiostatic...

Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: Implication for angiogenesis in fibrin matrices

Pericellular proteolysis plays an important role in cell migration and the formation of new capillary structures. The plasminogen activator/plasmin and matrix degrading metalloproteinase (MMP) cascades act together in the remodeling of matrix and cell-matrix contacts. Previously we have shown that the formation of capillary structures by human...

Unfractionated and low molecular weight heparin affect fibrin structure and angiogenesis in Vitro

Cancer patients treated for venous thromboembolism with low molecular weight heparin (LMWH) have a better survival rate than patients treated with unfractionated heparin (UFH). Because fibrin-associated angiogenesis is an important determinant in the progression and metastasis of many solid tumors, the effects of heparins on in vitro...

Effects of steroid hormones on the secretion of hemostatic factors in, and angiogenic properties of, human vascular endothelial cells