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Arnoldussen, I.A.C. (author), Wiesmann, M. (author), Pelgrim, C.E. (author), Wielemaker, E.M. (author), van Duyvenvoorde, W. (author), Amaral-Santos, P.L. (author), Verschuren, L. (author), Keijser, B.J.F. (author), Heerschap, A. (author), Kleemann, R. (author), Wielinga, P.Y. (author), Kiliaan, A.J. (author)Objective: Midlife obesity affects cognition and increases risk of developing dementia. Recent data suggest that intake of the short chain fatty acid butyrate could improve memory function, and may protect against diet-induced obesity by reducing body weight and adiposity. Subjects: We examined the impact of a high-fat diet (HFD) followed by...article 2017
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Pelgrim, C.E. (author), Franx, B.A.A. (author), Snabel, J. (author), Kleemann, R. (author), Arnoldussen, I.A.C. (author), Kiliaan, A.J. (author)Adipose tissue (AT) has a modulating role in obesity-induced metabolic complications like type 2 diabetes mellitus (T2DM) via the production of so-called adipokines such as leptin, adiponectin, and resistin. The adipokines are believed to influence other tissues and to affect insulin resistance, liver function, and to increase the risk of T2DM....article 2017