Preservation of Lean Mass upon Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes During 6-Months Follow-Up After RCT (PROBE Study)

Objectives. Weight loss is a key element in the treatment of obesity and type 2 diabetes (T2D), but also a risk factor for lean mass (LM) loss in older adults. We evaluated whether a whey protein drink enriched with leucine and vitamin D preserved LM during 3-month lifestyle intervention and whether effects sustained during 6 months follow-up...

Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-controlled, and crossover study

Polydextrose (PDX) reduces subsequent energy intake (EI) when administered at midmorning in single-blind trials of primarily normal-weight men. However, it is unclear if this effect also occurs when PDX is given at breakfast time. Furthermore, for ecological validity, it is desirable to study a female population, including those at risk for...

Systems biology of personalized nutrition

Personalized nutrition is fast becoming a reality due to a number of technological, scientific, and societal developments that complement and extend current public health nutrition recommendations. Personalized nutrition tailors dietary recommendations to specific biological requirements on the basis of a person’s health status and goals. The...

De verzadigende werking van groente en de relatie met overgewicht

Urine metabolomics combined with the personalized diagnosis guided by Chinese medicine reveals subtypes of pre-diabetes

The prevalence of type 2 diabetes continuously increases globally. A personalized strategy applied in the pre-diabetic stage is vital for diabetic prevention and management. The personalized diagnosis of Chinese Medicine (CM) may help to stratify the diabetics. Metabolomics is regarded as a potential platform to provide biomarkers for disease...

Improving service matching and selection in ubiquitous computingenvironments: A user study

In large ubiquitous computing environments it is hard for users to identify and activate the electronic services that match their needs. This user study compares the newly developed service matcher system with a conventional system for identifying and selecting appropriate services. The study addresses human factors issues such as usability,...

Randomized controlled trial assessing a traditional Chinese medicine remedy in the treatment of primary dysmenorrhea

A proof-of-concept study to assess the safety and efficacy of a traditional Chinese medicine formula as treatment for primary dysmenorrhea showed no statistically significant benefit over placebo. However, some efficacy parameters suggested possible superiority of the active treatment and so a larger study needs to be performed to determine...

Long-term gastrointestinal tolerance of NUTRIOSE®FB in healthy men

Objective: To determine the gastrointestinal (GI) tolerance of NUTRIOSE®FB in men. Design: A randomized, placebo-contro lled, parallel, double-blind study. Setting: The metabolic ward of TNO Quality of Life. Subjects: Forty-eight subjects started the study: 16 men participated in one of the three treatments. Subjects consumed either 22.5 g of...

Human-agent service matching using natural language queries: System test and training

Smart environments, ambient intelligence and intelligent agents leave the user lost between large amounts of services. Ad-hoc networks, mobile agents and mobile devices make the set of available services dynamic over time and space, increasing the user’s problems to find the service he needs. Earlier, we presented a ServiceMatcher that can find...

Maximising performance

Nutrition and performance

Dose-dependent effect of alpha-lactalbumin in combination with two different doses of glucose on the plasma Trp/LNAA ratio

A deficient brain serotonin function has been demonstrated in psychiatric disorders and increases in brain serotonin ameliorate emotional and behavioural abnormalities found in depression. The uptake of the serotonin precursor tryptophan into the brain is dependent on nutrients that influence the cerebral availability of tryptophan via a change...

De Montignac-methode: Een wetenschappelijke evaluatie