Searched for: author%3A%22Paauw%2C+A.%22
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Paauw, A. (author), Scholz, H.C. (author), Mars-Groenendijk, R.H. (author), Dekker, L.J.M. (author), Luider, T.M. (author), Leeuwen, H.C. (author)
Meliodosis and glanders are both potential biological threat agents. Glanders is endemic in Southeast Asia and Northern Australia but occasionally found in other countries. Meliodosis is caused by Burkholderia pseudomallei, while glanders is caused by Burkholderia mallei. The diagnosis of these diseases is difficult because the clinical picture...
article 2023
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Berghuis, N.F. (author), Mars-Groenendijk, R.H. (author), Busker, R.W. (author), Paauw, A. (author), van Leeuwen, H.C. (author)
CRISPR–Cas (CC)-based detection technologies have some exceptional features, which hold the promise of developing into the nextgeneration diagnostic platforms. One of these features is the ability to trigger non-specific single-stranded DNA/RNA cleavage activity after specific target recognition and Cas enzyme activation. This cleavage activity...
article 2022
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Paauw, A. (author), Balvers, M. (author), de Koning, J.C. (author), Voskamp-Visser, A.I. (author), Keijser, B.J.F. (author), Kieboom, J. (author), Leeuwen, H.C. (author), Levin, E. (author)
The COVID-19 pandemic, but also MERS, SARS-1, monkeypox and other emerging biological threats have shown the pitfalls of diagnostics targeting only one or, at best, a limited number of pathogens. To overcome this, a next generation diagnostic platform that is causative-agent agnostic is developed. Moreover, the method is able to identify 1895...
conference paper 2022
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Bogers, J.F.M. (author), Berghuis, N.F. (author), Busker, R.W. (author), van Booma, A. (author), Paauw, A. (author), van Leeuwen, H.C. (author)
Fluorescence-based diagnostic tools are attractive and versatile tests with multiple advantages: ease of use, sensitivity and rapid results. The advent of CRISPR-Cas technology has created new avenues for the development of diagnostic testing tools. In this study, by effectively combining the specific functions of two enzymes, CRISPR-Cas12a and...
article 2021
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Berendsen, E.M. (author), Levin, E. (author), Braakman, R.B.H. (author), Prodan, A. (author), van Leeuwen, H.C. (author), Paauw, A. (author)
To improve the preparedness against exposure to highly pathogenic bacteria and to anticipate the wide variety of bacteria that can cause bloodstream infections (BSIs), a safe, unbiased and highly accurate identification method was developed. Our liquid chromatography-tandem mass spectrometry (LC–MS/MS)-based method can identify highly pathogenic...
article 2019
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Berendsen, E.M. (author), Levin, E. (author), Braakman, R.B.H. (author), van der Riet-Van Oeveren, D. (author), Sedee, N.J. (author), Paauw, A. (author)
Aim: Bloodstream infections are a common cause of disease and a fast and accurate identification of the causative agent or agents of bloodstream infections would aid the start of adequate treatment. Materials & methods: A liquid chromatography-tandem mass spectrometry (LC-MS/MS) shotgun proteomics method was developed for the identification of...
article 2017
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Prodan, A. (author), Brand, H. (author), Imangaliyev, S. (author), Tsivtsivadze, E. (author), van der Weijden, F. (author), de Jong, A. (author), Paauw, A. (author), Crielaard, W. (author), Keijser, B. (author), Veerman, E. (author)
A cross-sectional observational study was conducted to evaluate the inter-individual variation in the MALDI-TOF MS peptide profiles of unstimulated whole saliva in a population of 268 systemically healthy adults aged 18-30 yr (150 males and 118 females) with no apparent caries lesions or periodontal disease. Using Spectral Clustering, four...
article 2016
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Majchrzykiewicz-Koehorst, J.A. (author), Heikens, E. (author), Trip, H. (author), Hulst, A.G. (author), de Jong, A.L. (author), Viveen, M.C. (author), Sedee, N.J.A. (author), van der Plas, J. (author), Coenjaerts, F.E.J. (author), Paauw, A. (author)
The rapid identification of existing and emerging respiratory viruses is crucial in combating outbreaks and epidemics. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid and reliable identification method in bacterial diagnostics, but has not been used in virological diagnostics. Mass...
article 2015
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Paauw, A. (author), Jonker, D. (author), Roeselers, G. (author), Heng, J.M.E. (author), Mars-Groenendijk, R.H. (author), Trip, H. (author), Molhoek, E.M. (author), Jansen, H.J. (author), van der Plas, J. (author), de Jong, A.L. (author), Majchrzykiewicz-Koehorst, J.A. (author), Speksnijder, A.G.C.L. (author)
E. coli-. Shigella species are a cryptic group of bacteria in which the Shigella species are distributed within the phylogenetic tree of E. coli. The nomenclature is historically based and the discrimination of these genera developed as a result of the epidemiological need to identify the cause of shigellosis, a severe disease caused by Shigella...
article 2015
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Trip, H. (author), Mende, K. (author), Majchrzykiewicz-Koehorst, J.A. (author), Sedee, N.J.A. (author), Hulst, A.G. (author), Jansen, H.J. (author), Murray, C.K. (author), Paauw, A. (author)
Shotgun proteomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was applied to detect β-lactamases in clinical Acinetobacter baumannii isolates. The correlation of the detection of β-lactamase proteins (rather than PCR detection of the corresponding genes) with the resistance phenotypes demonstrated an added value for LC-MS/MS...
article 2015
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Majchrzykiewicz-Koehorst, J.A. (author), Trip, H. (author), Coenjaerts, F. (author), Jong, A.L. (author), Hulst, A.G. (author), Sedee, N.J.A. (author), Heikens, E. (author), Paauw, A. (author)
conference paper 2014
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Majchrzykiewicz-Koehorst, J.A. (author), Heikens, E. (author), Trip, H. (author), Hulst, A.G. (author), de Jong, A.L. (author), Viveen, M.C. (author), Sedee, N.J.A. (author), van der Plas, J. (author), Coenjaerts, F.E.J. (author), Paauw, A. (author)
Tested respiratory viruses: influenza A virus, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), were successfully identified directly from crude cell cultures using liquid chromatography-tandem MS (LC-MS/MS). The identification was preceded with the simple, generic and fast sample preparation method. The determined...
conference paper 2014
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Paauw, A. (author), Trip, H. (author), Niemcewicz, M. (author), Sellek, R. (author), Heng, J.M.E. (author), Mars-Groenendijk, R.H. (author), de Jong, A.L. (author), Majchrzykiewicz-Koehorst, J.A. (author), Olsen, J.S. (author), Tsivtsivadze, E. (author)
Background Cholera is an acute diarrheal disease caused by Vibrio cholerae. Outbreaks are caused by a genetically homogenous group of strains from serogroup O1 or O139 that are able to produce the cholera toxin. Rapid detection and identification of these epidemic strains is essential for an effective response to cholera outbreaks. Results The...
article 2014
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Trip, H. (author), Niemcewicz, M. (author), Sellek, R. (author), Heng, J.M. (author), Mars-Groenendijk, R.H. (author), de Jong, A.L. (author), Majchrzykiewicz, J.A. (author), Olsen, J.S. (author), Tsivtsivadze, E. (author), Paauw, A. (author)
conference paper 2013
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Majchrzykiewicz-Koehorst, J.A. (author), Coenjaerts, F. (author), Trip, H. (author), Jong, A.L. (author), Hulst, A.G. (author), Heikens, E. (author), Paauw, A. (author)
conference paper 2013
document
Majchrzykiewicz-Koehorst, J.A. (author), Trip, H. (author), de Jong, A.L. (author), Coenjaerts, F.E.J. (author), Heikens, E. (author), Paauw, A. (author)
conference paper 2013
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Dybwad, M. (author), van der Laaken, A.L. (author), Blatny, J.M. (author), Paauw, A. (author)
Rapid and reliable identification of Bacillus anthracis spores in suspicious powders is important to mitigate the safety risks and economic burdens associated with such incidents. The aim of this study was to develop and validate a rapid and reliable laboratory- based matrix-assisted laser desorption ionization-time of flight mass spectrometry ...
article 2013
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Tsivtsivadze, E. (author), Heskes, T. (author), Paauw, A. (author)
In various learning problems data can be available in different representations, often referred to as views. We propose multi-class classification method that is particularly suitable for multi-view learning setting. The algorithm uses co-regularization and error-correcting techniques to leverage information from multiple views and in our...
conference paper 2013
document
Majchrzykiewicz-Koehorst, J.A. (author), Trip, H. (author), Coenjaerts, F. (author), Jong, A.L. (author), Hulst, A.G. (author), Sedee, N.J.A. (author), Heikens, E. (author), Paauw, A. (author)
conference paper 2013
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Coolen, J.P.M. (author), Sjödin, A. (author), Maraha, B. (author), Hajer, G.F. (author), Forsman, M. (author), Verspui, E. (author), Frenay, H.M.E. (author), Notermans, D.W. (author), de Vries, M.C. (author), Reubsaet, F.A.G. (author), Paauw, A. (author), Roeselers, G. (author)
Francisella tularensis is a facultative intracellular bacterium in the class Gammaproteobacteria. This strain is of interest because it is the etiologic agent of tularemia and a highly virulent category A biothreat agent. Here we describe the draft genome sequence and annotation of Francisella tularensis subsp. holarctica BD11-00177, isolated...
article 2013
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