- document
-
Vals-Delgado, C. (author), Alcala-Diaz, J.F. (author), Molina-Abril, H. (author), Roncero-Ramos, I. (author), Caspers, M.P.M. (author), Schuren, F.H.J. (author), van den Broek, T.J. (author), Luque, R. (author), Perez-Martinez, P. (author), Katsiki, N. (author), Delgado-Lista, J. (author), Ordovas, J.M. (author), van Ommen, B. (author), Camargo, A (author), Lopez-Miranda, J. (author)Introduction: A distinctive gut microbiome have been linked to type 2 diabetes mellitus (T2DM). Objectives: We aimed to evaluate whether gut microbiota composition, in addition to clinical biomarkers, could improve the prediction of new incident cases of diabetes in patients with coronary heart disease. Methods: All the patients from the...article 2022
- document
-
Kelly, J.M. (author), Matuszek, G. (author), van den Broek, T.J. (author), Huggins, G.S. (author), Smith, C.E. (author), Ordovas, J.M. (author), Wopereis, S. (author), Booth, S.L. (author)Inconsistent associations between lipids and circulating markers of fat-soluble vitamin and carotenoid status have been reported. The aim of this hypothesis-generating study was to examine the contribution of the LC-MS-based lipidome, characterized by lipid class, carbon count, and the number of unsaturated bonds, to the interindividual...article 2020
- document
-
Jiménez-Lucena, R. (author), Camargo, A. (author), Alcalá-Diaz, J.F. (author), Romero-Baldonado, C. (author), Luque, R.M. (author), van Ommen, B. (author), Delgado-Lista, J. (author), Ordovás, J.M. (author), Pérez-Martínez, P. (author), Rangel-Zúñiga, O.A. (author), López-Miranda, J. (author)We aimed to explore whether changes in circulating levels of miRNAs according to type 2 diabetes mellitus (T2DM) or prediabetes status could be used as biomarkers to evaluate the risk of developing the disease. The study included 462 patients without T2DM at baseline from the CORDIOPREV trial. After a median follow-up of 60 months, 107 of the...article 2018
- document
-
Blanco-Rojo, R. (author), Perez-Martinez, P. (author), Lopez-Moreno, J. (author), Martinez-Botas, J. (author), Delgado-Lista, J. (author), van Ommen, B. (author), Yubero-Serrano, E. (author), Camargo, A. (author), Ordovas, J.M. (author), Perez-Jimenez, F. (author), Gomez-Coronado, D. (author), Lopez-Miranda, J. (author)This prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years...article 2017
- document
-
Grimaldi, K.A. (author), van Ommen, B. (author), Ordovas, J.M. (author), Parnell, L.D. (author), Mathers, J.C. (author), Bendik, I. (author), Brennan, L. (author), Celis-Morales, C. (author), Cirillo, E. (author), Daniel, H. (author), de Kok, B. (author), El-Sohemy, A. (author), Fairweather-Tait, S.J. (author), Fallaize, R. (author), Fenech, M. (author), Ferguson, L.R. (author), Gibney, E.R. (author), Gibney, M. (author), Gjelstad, I.M.F. (author), Kaput, J. (author), Karlsen, A.S. (author), Kolossa, S. (author), Lovegrove, J. (author), Macready, A.L. (author), Marsaux, C.F.M. (author), Alfredo Martinez, J. (author), Milagro, F. (author), Navas-Carretero, S. (author), Roche, H.M. (author), Saris, W.H.M. (author), Traczyk, I. (author), van Kranen, H. (author), Verschuren, L. (author), Virgili, F. (author), Weber, P. (author), Bouwman, J. (author)Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendations for dietary choices that are more...article 2017
- document
-
Blanco-Rojo, R. (author), Alcala-Diaz, J.F. (author), Wopereis, S. (author), Perez-Martinez, P. (author), Quintana-Navarro, G.M. (author), Marin, C. (author), Ordovas, J.M. (author), van Ommen, B. (author), Perez-Jimenez, F. (author), Delgado-Lista, J. (author), Lopez-Miranda, J. (author)Aims/hypothesis: The aim of the study was to determine whether basal insulin resistance (IR) phenotype (muscle and/or liver) determines the effect of long-term consumption of a Mediterranean diet or a low-fat diet on tissue-specific IR and beta cell function. Methods: The study was performed in 642 patients included in The effect of an olive oil...article 2016
- document
-
van Ommen, B. (author), van der Greef, J. (author), Ordovas, J.M. (author), Daniel, H. (author)Metabolic adaptation to a disturbance of homeostasis is determined by a series of interconnected physiological processes and molecular mechanisms that can be followed in space (i.e., different organs or organelles) and in time. The amplitudes of these responses of this “systems flexibility network” determine to what extent the individual can...article 2014
- document
-
van Schalkwijk, D.B. (author), de Graaf, A.A. (author), Tsivtsivadze, E. (author), Parnell, L.D. (author), van der Werff-van der Vat, B.J.C. (author), van Ommen, B. (author), van der Greef, J. (author), Ordovás, J.M. (author)Background: Cardiovascular disease risk increases when lipoprotein metabolism is dysfunctional. We have developed a computational model able to derive indicators of lipoprotein production, lipolysis, and uptake processes from a single lipoprotein profile measurement. This is the first study to investigate whether lipoprotein metabolism...article 2014
- document
-
van Bochove, K. (author), van Schalkwijk, D.B. (author), Parnell, L.D. (author), Lai, C.Q. (author), Ordovás, J.M. (author), de Graaf, A.A. (author), van Ommen, B. (author), Arnett, D.K. (author)Fibrates lower triglycerides and raise HDL cholesterol in dyslipidemic patients, but show heterogeneous treatment response. We used k-means clustering to identify three representative NMR lipoprotein profiles for 775 subjects from the GOLDN population, and study the response to fenofibrate in corresponding subgroups. The subjects in each...article 2012
- document
-
TNO Kwaliteit van Leven (author), Williams, C.M. (author), Ordovas, J.M. (author), Lairon, D. (author), Hesketh, J. (author), Lietz, G. (author), Gibney, M. (author), Ommen, B. (author)Nutrition science finds itself at a major crossroad. On the one hand we can continue the current path, which has resulted in some substantial advances, but also many conflicting messages which impair the trust of the general population, especially those who are motivated to improve their health through diet. The other road is uncharted and is...article 2008
- document
-
TNO Kwaliteit van Leven (author), Kaput, J. (author), Ordovas, J.M. (author), Ferguson, L. (author), van Ommen, B. (author), Rodriguez, R.L. (author), Allen, L. (author), Ames, B.N. (author), Dawson, K. (author), German, B. (author), Krauss, R. (author), Malyj, W. (author), Archer, M.C. (author), Barnes, S. (author), Bortholomew, A. (author), Birk, R. (author), van Bladeren, P. (author), Bradford, K.J. (author), Brown, K.H. (author), Caetano, R. (author), Castle, D. (author), Chadwick, R. (author), Clarke, S. (author), Clemént, K. (author), Cooney, C.A. (author), Corella, D. (author), da Cruz, I.B.M. (author), Daniel, H. (author), Duster, T. (author), Ebbesson, S.O.E. (author), Elliott, R. (author), Fairweather-Tait, S. (author), Felton, J. (author), Fenech, M. (author), Finley, J.W. (author), Fogg-Johnson, N. (author), Gill-Garrison, R. (author), Gibney, M.J. (author), Gillies, P.J. (author), Gustafsson, J.A. (author), Hartman IV, J.L. (author), He, L. (author), Hwang, J.K. (author), Jais, J.P. (author), Jang, Y. (author), Joost, H. (author), Junien, C. (author), Kanter, M. (author), Kibbe, W.A. (author), Koletzko, B. (author), Korf, B.R. (author), Kornman, K. (author), Krempin, D.W. (author), Langin, D. (author), Lauren, D.R. (author), Lee, J.H. (author), Leveille, G.A. (author), Lin, S.J. (author), Mathers, J. (author), Mayne, M. (author), McNabb, W. (author), Milner, J.A. (author), Morgan, P. (author), Muller, M. (author), Nikolsky, Y. (author), van der Ouderaa, F. (author), Park, T. (author), Pensel, N. (author), Perez-Jimenez, F. (author), Poutanen, K. (author), Roberts, M. (author), Saris, W.H.M. (author), Schuster, G. (author), Shelling, A.N. (author), Simopoulos, A.P. (author), Southon, S. (author), Shyong Tai, E. (author), Towne, B. (author), Trayhurn, P. (author), Uauy, R. (author), Visek, W.J. (author), Warden, C. (author), Weiss, R. (author), Wiencke, J. (author), Winkler, J. (author), Wolff, G.L. (author), Zhao-Wilson, X. (author), Zucker, J.D. (author)Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can...article 2005