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Brouwer, D.H. (author), Aitken, R.J. (author), Oppl, R. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)This article proposes a common language for better understanding processes involved in dermal exposure and skin protection. A conceptual model has been developed that systematically describes the transport of agent mass from sources, eventually resulting in "loading" of the skin surface or the skin contaminant layer. In view of a harmonized...article 2005
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Warren, N. (author), Goede, H.A. (author), Tijssen, S.C.H.A. (author), Oppl, R. (author), Schipper, H.J. (author), van Hemmen, J.J. (author), TNO Voeding (author)This paper describes the derivation of default task-based dermal exposure values for use in a risk assessment toolkit for small and medium-sized enterprises (SMEs). A set of separately determined dermal exposure modifiers have been applied to published studies of dermal exposure to obtain 'normalized' dermal exposure data sets. These data sets...article 2003
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Schuhmacher-Wolz, U. (author), Kalberlah, F. (author), Oppl, R. (author), van Hemmen, J.J. (author), TNO Voeding (author)The toxicological background for hazard assessment using a simple to use toolkit for assessment and management of health risks from occupational dermal exposure is presented. Hazard assessment is intended to answer the following questions: (i) is the substance under consideration capable of damaging the skin; (ii) is the substance under...article 2003
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van Hemmen, J.J. (author), Auffarth, J. (author), Evans, P.G. (author), Rajan-Sithamparanadarajah, B. (author), Marquart, H. (author), Oppl, R. (author), TNO Voeding (author)Dermal exposure to industrial chemicals during work is of major concern in the risk assessment of chemicals. Current approaches in procedures for European legislation are not based on experimental data on dermal exposures in workplaces because these are lacking. A large project, with four interrelated work parts, was funded by the European...article 2003
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Goede, H.A. (author), Tijssen, S.C.H.A. (author), Schipper, H.J. (author), Warren, N. (author), Oppl, R. (author), Kalberlah, F. (author), van Hemmen, J.J. (author), TNO Voeding (author)This paper describes how default dermal exposure values can be adjusted with modifier values for specific work situations. The work presented here is supplementary to a toolkit developed for the EU RISKOFDERM project. This toolkit is intended for the assessment and management of dermal risks in small and medium sized enterprises. Potential...article 2003
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Oppl, R. (author), Kalberlah, F. (author), Evans, P.G. (author), van Hemmen, J.J. (author), TNO Voeding (author)The European Research project RISKOFDERM (QLK4-CT-1999-01107) has two major goals. One is the development of a conceptual model for dermal risk assessment for regulatory purposes, such as the registration of new chemicals. The other goal is to develop a simple-to-use toolkit for assessment and management of health risks from occupational dermal...article 2003
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Centraal Instituut voor Voedingsonderzoek TNO (author), Auffarth, J. (author), van Hemmen, J.J. (author), Hebisch, R. (author), Lechtenberg-Auffarth, E. (author), Marquart, J. (author), Oppl, R. (author), Rajan, B. (author), Wriedt, H. (author)Reducing dermal exposure to chemicals is a challenging task for occupational safety and health. In the European RISKOFDERM project 15 institutes in ten member states gather dermal exposure information and measurement data in relation to various tasks. First results are available. Based on this information i) a predictive model for estimating...article 2003