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Exploring the Effects of Environmental Factors on the Development of 0–4-Year Old Children in The Netherlands

van Wel, L. (author), van Dommelen, P. (author), Zuurbier, M. (author), Heinen, D. (author), Odink, J. (author), Bezem, J. (author), Verkerk, P.H. (author), Pronk, A. (author), Hoek, G. (author)

Air pollution, noise, and green space are important environmental exposures, having been linked to a variety of specific health outcomes. However, there are few studies addressing overall early life development. To assess their effects, associations between developmental milestones for a large population of 0–4-year old children in The...

article 2021

document

High resolution exposure modelling of heat and air pollution and the impact on mortality

Willers, S.M. (author), Jonker, M.F. (author), Klok, L. (author), Keuken, M.P. (author), Odink, J. (author), van den Elshout, S. (author), Sabel, C.E. (author), Mackenbach, J.P. (author), Burdorf, A. (author)

Background: Elevated temperature and air pollution have been associated with increased mortality. Exposure to heat and air pollution, as well as the density of vulnerable groups varies within cities. The objective was to investigate the extent of neighbourhood differences in mortality risk due to heat and air pollution in a city with a temperate...

article 2016

document

The importance of dietary control in the development of a peanut allergy model in Brown Norway rats

de Jonge, J.D. (author), Knippels, L.M.J. (author), Ezendam, J. (author), Odink, J. (author), Penninks, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)

article 2007

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The importance of dietary control in the development of a peanut allergy model in Brown Norway rats

de Jonge, J.D. (author), Knippels, L.M.J. (author), Ezendam, J. (author), Odink, J. (author), Penninks, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)

This report describes the further development of a peanut allergy model in Brown Norway (BN) rats and in particular the importance of allergen-free breeding of the laboratory animals for the allergen to be used. For this purpose BN rats were bred for 3 generations on soy- and peanut-free feed since it is known that the legumes peanut and soy are...

article 2007

document

Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats

de Jonge, J.D. (author), Ezendam, J. (author), Knippels, L.M.J. (author), Odink, J. (author), Pourier, M.S. (author), Penninks, A.H. (author), Pieters, R. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)

Other factors than the allergen itself may be of importance in the development of food allergy. This report describes the influence of the immunosuppressive compound bis(tributyltin)oxide (TBTO), present in the food chain, on the development of food allergy to peanut or ovalbumin in Brown Norway (BN) rats. To study these effects BN rats were...

article 2007

document

The interaction of the lipase inhibitor orlistat with ethanol in healthy volunteers

Melia, A.T. (author), Zhi, J. (author), Zelasko, R. (author), Hartmann, D. (author), Güzelhan, C. (author), Guerciolini, R. (author), Odink, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

article 1998

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A randomized three-way cross-over study in healthy pituitary-suppressed women to compare the bioavailability of human chorionic gonadotrophin (Pregnyl®) after intramuscular and subcutaneous administration

Mannaerts, B.M.J.L. (author), Geurts, T.B.P. (author), Odink, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The objective of this study was to compare the bioavailability of s.c. and i.m. administration of human chorionic gonadotrophin (HCG; Pregnyl®). In a randomized, single centre, three-way cross-over study, 18 healthy pituitary-suppressed volunteers were assigned to single HCG injections of 5000 and 10000 IU i.m. and 10000 IU s.c. Rate (C(max), t...

article 1998

document

Lack of interaction between orlistat and oral contraceptives

Hartmann, D. (author), Güzelhan, C. (author), Zuiderwijk, P.B.M. (author), Odink, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Objectives: Orlistat, a potent and selective inhibitor of gastrointestinal lipases, is designed for the treatment of obesity. A double-blind, randomised, placebo-controlled, 2-way crossover study investigated the possible influence of orlistat on the ovulation-suppressing action of combination oral contraceptives (OC). Methods: After an 8-day...

article 1996

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A prospective, double-blind, split-subject study on local skin reactions after administration of human menopausal gonadotrophin preparations to healthy female volunteers

Odink, J. (author), Zuiderwijk, P.B.M. (author), Schoen, E.D. (author), Gan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

This study was designed to investigate local reactions after the intracutaneous (i.c.) administration of two human menopausal gonadotrophin preparations. For this purpose, 20 healthy female volunteers received six i.c. injections simultaneously, viz. three different batches of both Humegon (Organon, Oss, The Netherlands) and Pergonal (Serono,...

article 1995

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Influence of dietary composition on the inhibition of fat absorption by orlistat

Güzelhan, C. (author), Odink, J. (author), Niestijl Jansen-Zuidema, J.J. (author), Hartmann, D. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

article 1994

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Marginal nutritional status among institutionalized elderly women as compared to those living more independently (Dutch Nutrition Surveillance System)

Löwik, M.R.H. (author), van den Berg, H. (author), Schrijver, J. (author), Odink, J. (author), Wedel, M. (author), van Houten, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

article 1992

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Nutrition and blood pressure among elderly men and women (Dutch Nutrition Surveillance System)

Löwik, M.R.H. (author), Hofman, Z. (author), Kok, F.J. (author), Wedel, M. (author), Hulshof, K.F.A.M. (author), Odink, J. (author), Schaafsma, G. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

Associations between blood pressure and nutrition-related variables (body mass index, dietary intake, and 24-hr excretion of sodium, potassium, magnesium, and calcium in the urine) were investigated in men (n = 138) and women (n = 117) 65-79 years old not using drugs known to affect blood pressure and not on a diet. Among men, body mass index...

article 1991

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Simultaneous measurement of serotonin and 5-hydroxyindoleacetic acid in rat brain using a liquid chromatographic method with electrochemical detection

de Vries, M. (author), Odink, J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

A simple and sensitive method for the simultaneous measurement of 5-hydroxytryptamine and its main metabolite 5-hydroxyindoleacetic acid in rat brain is described. Brain tissue samples were only deproteinated and, without further extraction, were injected directly onto a high-performance liquid chromatography column and detected...

article 1991

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Nutrition and aging: Nutritional status of ''apparently healthy'' elderly (Dutch nutrition surveillance system)

Lowik, M.R.H. (author), Schrijver, J. (author), Odink, J. (author), van den Berg, H. (author), Wedel, M. (author), Hermus, R.J.J. (author), TNO Kwaliteit van Leven (author)

In a nationwide survey the nutritional status was assessed of 539 apparently healthy, independently living elderly aged 65-79 years. Anthropometric data showed no energy deficits. The prevalence of anemia was 4 and 1% among men and women, respectively. Many elderly showed a low level of 25-hydroxyvitamin D in plasma (< 31 nmol/L: men 35%; women...

article 1990

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Polyunsaturated fatty acid consumption, plasma cholesterol concentration and neuroendocrine response to mental and physical task load

Odink, J. (author), Kramer, F.M. (author), van der Beek, E.J. (author), Thissen, J.T.N.M. (author), Kempen, H.J.M. (author), van den Berg, H. (author), Egger, R.J. (author), Wientjes, C.J.E. (author), CIVO-TNO Nederlands instituut voor praeventieve gezondheidszorg TNO, NIPG-TNO Gaubius instituut TNO, GI-TNO Instituut voor zintuigfysiologie TNO, IZF-TNO (author)

This study was designed to investigate the relation between fatty acid consumption, total plama cholesterol and neuroendocrine response to exposure to stress, factors thought to play a role in the development of coronary heart disease. For this purpose 32 apparently healthy male volunteers were classified on the basis of their plasma cholesterol...

article 1989

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Onderzoek naar de samenhang tussen bloeddruk en mineralenvoorziening bij Nederlandse ouderen

Hofman, Z. (author), Löwik, M.R.H. (author), Odink, J. (author), Kok, F.J. (author)

article 1989

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Sex and age dependency on the concentration of the major biogenic amine metabolites in human cevebrospinal fluid as determined with isocratic reversed-phase high-performance liquid chromatography and electrochemical detection

Odink, J. (author), Korthals, H. (author), Vette, G.M. (author)

article 1987

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Type A behaviour, borderline hyperventilation and psychological, psychosomatic and neuroendocrine responses to mental task load

Centraal Instituut voor Voedingsonderzoek TNO (author), Odink, J. (author), Wientjes, C.J.E. (author), Thissen, J.T.N.M. (author), van der Beek, E.J. (author), Kramer, F.M. (author)

Psychological, psychosomatic and neuroendocrine (in blood) responses to mental task load were investigated in relation to type A behaviour and borderline hyperventilation. For this purpose 32 apparently healthy, male volunteers were classified on the basis of their scores on the Jenkins Activity Survey (JAS) and on a questionnaire assessing...

article 1987

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Influence of tryptophan loading on urinary excretion of anthranilic acid and 3-hydroxyanthranilic acid by men and women as determined by alkali flame ionization gas chromatography

van der Poll, J.M. (author), Vink, M. (author), Schrijver, J. (author), Odink, J. (author), Centraal instituut voor voedingsonderzoek TNO (author)

A gas chromatographic method with alkali flame ionization detection is described for the determination of urinary total (free and conjugated) anthranilic acid (AA) and 3-hydroxyanthranilic acid (HAA) as their pentafluorobenzyl esters. Prior to analysis, urine was hydrolysed using hydrochloric acid in a boiling water bath. The highest AA and HAA...

article 1986

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Effect of work load on free and sulfate-conjugated plasma catecholamines, prolactin, and cortisol

Instituut CIVO-Toxicologie en voeding TNO (author), Odink, J. (author), van der Beek, E.J. (author), van den Berg, H. (author), Bogaards, J.J.P. (author), Thissen, J.T.N.M. (author)

The effects of maximal performance capacity and different work load intensities on the response of free and sulfate-conjugated plasma catecholamines, prolactin (PRL), and cortisol were studied in six healthy male volunteers. In a first experiment, the volunteers had to perform a step-wise incremental bicycle ergometer test to determine the onset...

article 1986