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de Bruin-Hoegée, J.M. (author), Lamriti, L. (author), Langenberg, J.P. (author), Olivier, R.C.M. (author), Chau, L.F. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)The continuing threats of military conflicts and terrorism may involve the misuse of chemical weapons. The present study aims to use environmental samples to find evidence of the release of such agents at an incident scene. A novel approach was developed for identifying protein adducts in plants. Basil (Ocimum basilicum), bay laurel leaf (Laurus...article 2023
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Holmgren, K.H. (author), Hakulinen, H. (author), Norlin, R. (author), de Bruin-Hoegée, J.M. (author), Spiandore, M. (author), See, S.Q.S. (author), Webster, R. (author), Jacques, K.L. (author), Mauravaara, L. (author), Ang, L.H. (author), Evans, C.P. (author), Ovenden, S. (author), Noort, D. (author), Delaporte, G. (author), Dahlén, J. (author), Fraga, C.G. (author), Vanninen, P. (author), Åstot, C. (author)An interlaboratory evaluation of a chemical profiling method for a nerve agent precursor was performed by eight chemical analytical laboratories with a wide global distribution. A set of chemical attribution signatures (i.e. impurities) present in methylphosphonic dichloride (DC) were analysed by gas chromatography-mass spectrometry (GC/MS). The...article 2023
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de Bruin-Hoegée, J.M. (author), Schoorl, J. (author), Zoon, P. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)Plastic materials are often found on crime scenes in improvised explosive devices. Determining the trace-elemental composition of polymer parts may yield discrimination between samples from different sources. Although quantitative laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) is well established for forensic glass...article 2023
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de Bruin-Hoegee, J.M. (author), Fidder, A. (author), van Groningen, T. (author), van der Schans, M.J. (author), Noort, D. (author), van Asten, A.C. (author)The analysis of biomedical samples is important for the investigation of the alleged exposure to chemical warfare agents. The present study aims to use dried blood spots for portable detection and laboratory verification of organophosphate poisoning. After in-vitro incubation of blood with Novichok A-230, A-232 and A-234 and sarin, a volume of...article 2023
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- de Bruin-Hoegee, J.M. (author), van Damme, I.M. (author), van der Riet-van Oeveren, D. (author), Noort, D. (author), van Asten, A. (author) conference paper 2022
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- de Bruin-Hoegee, J.M. (author), Noort, D. (author), van Asten, A. (author) conference paper 2022
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- de Bruin-Hoegee, J.M. (author), Noort, D. (author), van Asten, A. (author) conference paper 2022
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- de Bruin-Hoegee, J.M. (author), van Damme, I.M. (author), Noort, D. (author), van Asten, A. (author) conference paper 2022
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van den Berg, R.M. (author), Joosen, M.J.A. (author), Savransky, V. (author), Cochrane, L. (author), Noort, D. (author)Ricin is a proteinaceous toxin, listed on the schedules of both the chemical and biological weapons conventions. The ease of accessibility to the Ricinus communis plant and toxin extraction makes ricin a viable concern for use of intentional release and causal effects. The adverse effects following exposure to the toxin are caused by the...article 2022
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- Durán Jiménez, D. (author), de Bruin-Hoegee, J.M. (author), Alkema, D.P.W. (author), Noort, D. (author), Busker, R.W. (author), van Wuijckhuijse, A.L. (author) conference paper 2022
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de Bruin-Hoegée, J.M. (author), van Damme, I.M. (author), van Groningen, T. (author), van der Riet-van Oeveren, D. (author), Noort, D. (author), van Asten, A.C. (author)Chlorine is a widely available industrial chemical and involved in a substantial number of cases of poisoning. It has also been used as a chemical warfare agent in military conflicts. To enable forensic verification, the persistent biomarkers 3-chlorotyrosine and 3,5-dichlorotyrosine in biomedical samples could be detected. An important...article 2022
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- de Bruin-Hoegée, J.M. (author), van Damme, I.M. (author), Noort, D. (author), van Asten, A. (author) conference paper 2022
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Noort, D. (author), Fidder, A. (author), van der Riet-van Oeveren, D. (author), Busker, R.W. (author), van der Schans, M.J. (author)Novichok (NV) nerve agents were recently added to the list of Schedule 1 chemicals of the Chemical Weapons Convention. There is a well-accepted method for assessment of nerve agent exposure based on mass spectrometric analysis of a nonapeptide with the serine-198 residue modified by the nerve agent, but this approach has not yet been reported...article 2021
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Hemme, M. (author), Fidder, A. (author), van der Riet-van Oeveren, D. (author), van der Schans, M.J. (author), Noort, D. (author)The primary aim of this study was to identify biomarkers of exposure to some so-called Schedule 1 sulfur mustard (HD) analogues, in order to facilitate and expedite their retrospective analysis in case of alleged use of such compounds. Since these HD analogues can be regarded as model compounds for possible impurities of HD formed during...article 2021
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Onder, S. (author), van Grol, M. (author), Fidder, A. (author), Xiao, G. (author), Noort, D. (author), Yerramalla, U. (author), Tacal, O. (author), Schopfer, L.M. (author), Lockridge, O. (author)Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of neurodegenerative disease. The mechanism of neurotoxicity is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organophosphorus pesticides, the most stable being adducts on tyrosine....article 2021
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de Bruin-Hoegee, J.M. (author), Kleiweg, D. (author), Noort, D. (author), van Asten, A.C. (author)Chemical attribution typically aims to establish a link between material found at a crime scene and a person, location or other evidence. In the field of illicit drugs, chemical attribution signatures are usually impurity profiles. Extending these to metabolized samples would create new possibilities in forensic investigations. The present study...article 2021
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Noort, D. (author), van der Schans, M.J. (author), Black, R.M. (author)In this article, an overview is presented of the methods that are currently available for retrospective detection of exposure to a number of chemical warfare agents (CWAs), based on adducts formed with macromolecules such as proteins. These methods can be applied for various purposes, e.g. diagnosis and dosimetry of exposure of casualties,...bookPart 2020
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Borrett, V. (author), Hanham, M. (author), Jeremias, G. (author), Forman, J. (author), Revill, J. (author), Borrie, J. (author), Åstot, C. (author), Baulig, A. (author), Curty, C. (author), Dorner, B.G. (author), Fraga, C. (author), Gonzalez, D. (author), Mikulak, R. (author), Noort, D. (author), Raza. S. K., (author), Tang. C., (author), Timperley, C. (author), van Straten, F.M. (author), van Zalen, E. (author), Vanninen, P. (author), Waqar, F. (author)The integration of novel technologies for monitoring and investigating compliance can enhance the effectiveness of regimes related to weapons of mass destruction (WMD). This report looks at the potential role of four novel approaches based on recent technological advances – remote sensing tools; open-source satellite data; open-source trade data...report 2020
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- Field, M. (author), Splevins, A. (author), Picaut, P. (author), van der Schans, M. (author), Langenberg, J. (author), Noort, D. (author), Snyder, D. (author), Foster, K. (author) article 2019
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Field, M. (author), Splevins, A. (author), Picaut, P. (author), van der Schans, M. (author), Langenberg, J. (author), Noort, D. (author), Foster, K. (author)Botulinum neurotoxin type-A (BoNT-A) blocks the release of acetylcholine from peripheral cholinergic nerve terminals and is an important option for the treatment of disorders characterised by excessive cholinergic neuronal activity. Several BoNT-A products are currently marketed, each with unique manufacturing processes, excipients, formulation,...article 2018