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Falke, L.L. (author), Kinashi, H. (author), Dendooven, A. (author), Broekhuizen, R. (author), Stoop, R. (author), Joles, J.A. (author), Nguyen, T.Q. (author), Goldschmeding, R. (author)Age is associated with an increased prevalence of chronic kidney disease (CKD), which, through progressive tissue damage and fibrosis, ultimately leads to loss of kidney function. Although much effort is put into studying CKD development experimentally, age has rarely been taken into account. Therefore, we investigated the effect of age on the...article 2016
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van der Heijden, R.A. (author), Bijzet, J. (author), Meijers, W.C. (author), Yakala, G.K. (author), Kleemann, R. (author), Nguyen, T.Q. (author), de Boer, R.A. (author), Schalkwijk, C.G. (author), Hazenberg, B.P.C. (author), Tietge, U.J.F. (author), Heeringa, P. (author)Obesity-induced inflammation presumably accelerates the development of chronic kidney diseases. However, little is known about the sequence of these inflammatory events and their contribution to renal pathology. We investigated the effects of obesity on the evolution of age-dependent renal complications in mice in conjunction with the...article 2015
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Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidneyFalke, L.L. (author), Dendooven, A. (author), Leeuwis, J.W. (author), Nguyen, T.Q. (author), van Geest, R.J. (author), van der Giezen, D.M. (author), Broekhuizen, R. (author), Lyons, K. (author), Stoop, R. (author), Kemperman, H. (author), Schlingemann, R. (author), Joles, J.A. (author), Goldschmeding, R. (author)Background: Connective Tissue Growth Factor (CTGF/CCN2) is an important mediator of kidney fibrosis. Previous observations indicated that attenuation of CCN2 expression sufficed to alleviate early kidney damage. However, little is known about the role of CCN2 in fibrosis of severely damaged and more chronically injured kidneys. Therefore, we...article 2012
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Mikhnenko, O.V. (author), Lin, J. (author), Shu, Y. (author), Antony, J.E. (author), Blom, P.W.M. (author), Nguyen, T.Q. (author), Loi, M.A. (author)We show that the method we have developed for measuring the singlet exciton diffusion length in blends with [6,6]-phenyl-C 61-butyric acid methyl ester (PCBM) can be applied not only to polymeric materials, but also to small molecule organic semiconductors. Small organic molecules have a large potential for molecular re-organization upon thermal...article 2012