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de Jong, A.J. (author), Klein-Wietinga, I.R. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Herb-van Toorn, L. (author), de Lange-Brokaar, B.J.E. (author), van Delft, D. (author), Garcia, J. (author), Wei, W. (author), van der Heide, H.J.L. (author), Bastiaanen-Jenniskens, Y.M. (author), van Osch, G.J.V.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Toes, R.E.M. (author), Kloppenburg, M. (author), Ioan-Facsinay, A. (author)Background. Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and...article 2017
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), Yusuf, E. (author), Kroon, H.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Bloem, J.L. (author), Kloppenburg, M. (author)Objective: To investigate the course of synovitis on contrast-enhanced magnetic resonance images (CE-MRI) in osteoarthritic knees over 2 years, and its association with pain and cartilage deterioration. Design: Consecutive patients (n = 39, mean age 61 years, 79% woman, median (range) body mass index (BMI) 29 (24-48) kg/mm2) with clinical...article 2016
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Klein-Wieringa, I.R. (author), de Lange-Brokaar, B.J. (author), Yusuf, E. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Kroon, H.M. (author), van Osch, G.J. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Toes, R.E. (author), Kloppenburg, M. (author), Ioan-Facsinay, A. (author)Objective: To get a better understanding of inflammatory pathways active in the osteoarthritic (OA) joint, we characterized and compared inflammatory cells in the synovium and the infrapatellar fat pad (IFP) of patients with knee OA. Methods: Infiltrating immune cells were characterized by flow cytometry in 76 patients with knee OA (mean age 63...article 2016
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Klein-Wieringa, I.R. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Giera, M. (author), de Lange-Brokaar, B.J. (author), van Osch, G.J. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Pijl, H. (author), Huizinga, T.W. (author), Kloppenburg, M. (author), Toes, R.E. (author), Ioan-Facsinay, A. (author)Previous studies have shown accumulation and an enhanced proinflammatory profile of macrophages in adipose tissue of obese mice, indicating the presence of an interaction between adipocytes and macrophages in this tissue. However, the consequences of this interaction in humans are yet incompletely understood. In this study, we explored the...article 2013
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TNO Kwaliteit van Leven (author), Yusuf, E. (author), Nelissen, R.G. (author), Ioan-Facsinay, A. (author), Stojanovic-Susulic, V. (author), de Groot, J. (author), van Osch, G. (author), Middeldorp, S. (author), Huizinga, T.W.J. (author), Kloppenburg, M. (author)Objective: To investigate the association between weight or body mass index (BMI) and the development of hand osteoarthritis. Methods: Systematic review of observational studies. Medical databases were searched up to April 2008. Articles that presented data on the association between weight and hand osteoarthritis were selected. The qualities of...article 2010
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Dortmans, A. (author), Batenburg, L.F. (author), Koster, T.P.M. (author), Nelissen, R.G. (author), Fischer, H. (author), TNO Industrie en Techniek (author)A porous PMMA material has been reinforced by clay particles, and properties of the resulting material were evaluated. The clay has been intercalated in a first step by melt-extrusion with a suitable block copolymer. A radical polymerisation reaction after swelling of the intercalated clay with monomer leads in a subsequent step to a...article 2002