Searched for: author%3A%22Mulder%2C+P.%22
(1 - 20 of 20)
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Mulder, P. (author), Boonman, H. (author), Sterkenburg, R. (author)
Het plaatsen van meer windturbines op land is een belangrijk onderdeel van de strategie om de klimaatdoelstellingen in Nederland te halen. Maar windturbines geven overlast door geluid en slagschaduw en hebben impact op het landschapsbeeld. Deze ‘externe effecten’ van windturbines op hun directe omgeving hebben een aantoonbaar negatief effect op...
report 2022
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Mahumane, G. (author), Mulder, P. (author)
What is the impact of the unprecedented scale and pace of urbanization in the global South on the evolution of energy poverty incidence? Remarkably enough, urban population growth and energy poverty are mainly studied separately from each other in different strands of the literature. We argue that there is much to be gained in studying these...
article 2022
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Straver, K. (author), van Grieken, A. (author), Mulder, P. (author), Geitenbeek, L. (author), Geertjes, K. (author)
report 2021
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Díaz-Lanchas, J. (author), Mulder, P. (author)
The worldwide trend to decentralize the responsibilities and budgets of governments impacts regional economies in various ways. We use the example of Spain to test empirically whether the decentralization of governance is an important determinant of the sectoral composition of cities in an urban system. Our regression results, exploiting unique...
article 2021
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Mulder, P. (author), Dalla Longa, F. (author), Straver, K. (author)
Leidt de transitie naar een duurzaam energiesysteem tot meer energiearmoede? Het antwoord op die vraag vereist allereerst inzicht in de aard en omvang van het energiearmoede probleem – meten is weten. Goede indicatoren en data kunnen een effectieve basis zijn voor gerichte maatregelen en structurele monitoring van de ontwikkeling van...
report 2021
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Straver, K. (author), Mulder, P. (author), Middlemiss, L. (author), Hesselman, M. (author), Feenstra, M. (author), Tirado Herrero, S. (author)
The transition to a sustainable energy system entails major changes in both the economy and society. Without introducing special measures, the costs and benefits of the energy transition are unlikely to be equally distributed amongst different groups in society. In other words, the energy transition will have major consequences on our prosperity...
report 2020
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Kozijn, A.E. (author), Gierman, L.M. (author), van der Ham, F. (author), Mulder, P. (author), Morrison, M.C. (author), Kühnast, S. (author), van der Heijden, R.A. (author), Stavro, P.M. (author), van Koppen, A. (author), Pieterman, E.J. (author), van den Hoek, A.M. (author), Kleemann, R. (author), Princen, H.M.G. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author), Zuurmond, A.M. (author), Bobeldijk, I. (author), Weinans, H. (author), Stoop, R. (author)
Objective. Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation in the knees of mice from different genetic backgrounds in which a metabolic phenotype was...
article 2018
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Mulder, P. (author), van den Hoek, A.M. (author), Kleenann, R. (author)
Background and aim. Obese patients with chronic inflammation in white adipose tissue (WAT) have an increased risk of developing non-alcoholic steatohepatitis (NASH). The C-C chemokine receptor-2 (CCR2) has a crucial role in the recruitment of immune cells to WAT and liver, thereby promoting the inflammatory component of the disease. Herein, we...
article 2017
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Mulder, P. (author), Morrison, M.C. (author), Verschuren, L. (author), Liang, W. (author), van Bockel, J.H. (author), Kooistra, T. (author), Wielinga, P.Y. (author), Kleemann, R. (author)
Obesity is associated with chronic low-grade inflammation that drives the development of metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). We recently showed that white adipose tissue (WAT) constitutes an important source of inflammatory factors. Hence, interventions that attenuate WAT inflammation may reduce NAFLD...
article 2016
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van der Heijden, R.A. (author), Morrison, M.C. (author), Sheedfar, F. (author), Mulder, P. (author), Schreurs, M. (author), Hommelberg, P.P.H. (author), Hofker, M.H. (author), Schalkwijk, C. (author), Kleemann, R. (author), Tietge, U.J.F. (author), Koonen, D.P.Y. (author), Heeringa, P. (author)
Background. Naturally occurring substances from the flavanol and anthocyanin family of polyphenols have been proposed to exert beneficial effects in the course of obesity. We hypothesized that their effects on attenuating obesity-induced dyslipidemia as well as the associated inflammatory sequelae especially have health-promoting potential....
article 2016
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Morrison, M.C. (author), Mulder, P. (author), Salic, K. (author), Verheij, J. (author), Liang, W. (author), van Duyvenvoorde, W. (author), Menke, A. (author), Kooistra, T. (author), Kleemann, R. (author), Wielinga, P.Y. (author)
Background/objectives: Non-alcoholic steatohepatitis (NASH) is a serious liver condition, closely associated with obesity and insulin resistance. Recent studies have suggested an important role for inflammasome/caspase-1 in the development of NASH, but the potential therapeutic value of caspase-1 inhibition remains unclear. Therefore, we aimed...
article 2016
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Mulder, P. (author), Morrison, M.C. (author), Wielinga, P.Y. (author), van Duyvenvoorde, W. (author), Kooistra, T. (author), Kleemann, R. (author)
Background: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with abdominal obesity. Growing evidence suggests that inflammation in specific depots of white adipose tissue (WAT) has a key role in NAFLD progression, but experimental evidence for a causal role of WAT is lacking. Methods: A time-course study in C57BL/6J mice was...
article 2016
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Liang, W. (author), Verschuren, L. (author), Mulder, P. (author), van der Hoorn, J.W.A. (author), Verheij, J. (author), van Dam, A.D. (author), Boon, M.R. (author), Princen, H.M.G. (author), Havekes, L.M. (author), Kleemann, R. (author), van den Hoek, A.M. (author)
BACKGROUND AND PURPOSE: Salsalate (salicylsalicylic acid) is an anti-inflammatory drug that was recently found to exert beneficial metabolic effects on glucose and lipid metabolism. Although its utility in the prevention and management of a wide range of vascular disorders, including type 2 diabetes and metabolic syndrome has been suggested...
article 2015
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Morrison, M.C. (author), Liang, W. (author), Mulder, P. (author), Verschuren, L. (author), Pieterman, E. (author), Toet, K. (author), Heeringa, P. (author), Wielinga, P.Y. (author), Kooistra, T. (author), Kleemann, R. (author)
Background & Aims Anthocyanins may have beneficial effects on lipid metabolism and inflammation and are demonstrated to have hepatoprotective properties in models of restraint-stress- and chemically-induced liver damage. However, their potential to protect against non-alcoholic steatohepatitis (NASH) under conditions relevant for human...
article 2015
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Mulder, P. (author), Stavro, P.M. (author), Manuel Suárez, M. (author), Arola-Arnal, A. (author), van Duyvenvoorde, W. (author), Kooistra, T. (author), Wielinga, P.Y. (author), Kleemann, R. (author)
Background and Aims As dietary saturated fatty acids are associated with metabolic and cardiovascular disease, a potentially interesting strategy to reduce disease risk is modification of the quality of fat consumed. Vegetable oils represent an attractive target for intervention, as they largely determine the intake of dietary fats. Furthermore,...
article 2015
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Liang, W. (author), Tonini, G. (author), Mulder, P. (author), Kelder, T. (author), van Erk, M. (author), van den Hoek, A.M. (author), Mariman, R. (author), Wielinga, P.Y. (author), Baccini, M. (author), Kooistra, T. (author), Biggeri, A. (author), Kleemann, R. (author)
Background:Chronic metabolic overload results in lipid accumulation and subsequent inflammation in white adipose tissue (WAT), often accompanied by non-alcoholic fatty liver disease (NAFLD). In response to metabolic overload, the expression of genes involved in lipid metabolism and inflammatory processes is adapted. However, it still remains...
article 2013
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van Deelen, J. (author), Bauhuis, G.J. (author), Schermer, J.J. (author), Mulder, P. (author), Haverkamp, E.J. (author), Larsen, P.K. (author), TNO Industrie en Techniek (author)
article 2007
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Schermer, J.J. (author), Bauhuis, G.J. (author), Mulder, P. (author), Haverkamp, E. (author), van Deelen, J. (author), van Niftrik, A.T.J. (author), Larsen, P.K. (author), TNO Industrie en Techniek (author)
article 2006
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van Deelen, J. (author), Mulder, P. (author), Bauhuis, G.J. (author), van Niftrik, A.T.J. (author), Haverkamp, E.J. (author), Schermer, J.J. (author), Larsen, P.K. (author), TNO Industrie en Techniek (author)
article 2006
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Schermer, J.J. (author), Mulder, P. (author), Bauhuis, G.J. (author), Voncken, M.M.A.J. (author), van Deelen, J. (author), Haverkamp, E. (author), Larsen, P.K. (author), TNO Industrie en Techniek (author)
article 2005
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