Searched for: author:"Muilwijk, B."
(1 - 14 of 14)
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Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)
One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...
article 2014
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Zha, Y. (author), Westerhuis, J.A. (author), Muilwijk, B. (author), Overkamp, K.M. (author), Nijmeijer, B.M. (author), Coulier, L. (author), Smilde, A.K. (author), Punt, P.J. (author)
Background: Inhibitors are formed that reduce the fermentation performance of fermenting yeast during the pretreatment process of lignocellulosic biomass. An exometabolomics approach was applied to systematically identify inhibitors in lignocellulosic biomass hydrolysates.Results: We studied the composition and fermentability of 24 different...
article 2014
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Coulier, L. (author), Muilwijk, B. (author), Bijlsma, S. (author), Noga, M. (author), Tienstra, M. (author), Attali, A. (author), van Aken, H. (author), Suidgeest, E. (author), Tuinstra, T. (author), Luider, T.M. (author), Hankemeier, T. (author), Bobeldijk, I. (author)
Analysis of metabolites in biofluids by gas chromatography-mass spectrometry (GC-MS) after oximation and silylation is a key method in metabolomics. The GC-MS method was modified by a modified vial design and sample work-up procedure in order to make the method applicable to small volumes of cerebrospinal fluid (CSF), i. e. 10 μL, with similar...
article 2013
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Noga, M.J. (author), Dane, A. (author), Shi, S. (author), Attali, A. (author), van Aken, H. (author), Suidgeest, E. (author), Tuinstra, T. (author), Muilwijk, B. (author), Coulier, L. (author), Luider, T. (author), Reijmers, T.H. (author), Vreeken, R.J. (author), Hankemeier, T. (author)
Experimental Autoimmune Encephalomyelitis (EAE) is the most commonly used animal model for Multiple Sclerosis (MScl). CSF metabolomics in an acute EAE rat model was investigated using targetted LC-MS and GC-MS. Acute EAE in Lewis rats was induced by co-injection of Myelin Basic Protein with Complete Freund's Adjuvant. CSF samples were collected...
article 2012
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Coulier, L. (author), Muilwijk, B. (author), Bijlsma, S. (author), Noga, M. (author), Tienstra, M. (author), Attali, A. (author), van Aken, H. (author), Suidgeest, E. (author), Tuinstra, T. (author), Hankemeier, T. (author), Bobeldijk, I. (author)
Analysis of metabolites in biofluids by gas chromatography–mass spectrometry (GC–MS) after oximation and silylation is a key method in metabolomics. The GC–MS method was modified by a modified vial design and sample work-up procedure in order to make the method applicable to small volumes of cerebrospinal fluid (CSF), i.e. 10 μL, with similar...
article 2012
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Zha, Y. (author), Muilwijk, B. (author), Coulier, L.C. (author), Punt, P.J. (author)
To compare the composition and performance of various lignocellulosic biomass hydrolysates as fermentation media, 8 hydrolysates were generated from a grass-like and a wood biomass. The hydrolysate preparation methods used were 1) dilute acid, 2) mild alkaline, 3) alkaline/peracetic acid, and 4) concentrated acid. These hydrolysates were...
article 2012
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Bobeldijk-Pastorova, I. (author), Muilwijk, B. (author), Kramer, J. (author), Hekman, M. (author), Tummers, P. (author), Boon, P. (author), Lith, A. (author), van Veen, J.J.F. (author)
conference paper 2011
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Rosenling, T. (author), Stoop, M.P. (author), Smolinska, A. (author), Muilwijk, B. (author), Coulier, L. (author), Shi, S. (author), Dane, A. (author), Christin, C. (author), Suits, F. (author), Horvatovich, P.L. (author), Wijmenga, S.S. (author), Buydens, L.M.C. (author), Vreeken, R. (author), Hankemeier, T. (author), van Gool, A.J. (author), Luider, T.M. (author), Bischoff, R. (author)
BACKGROUND: Because cerebrospinal fluid (CSF) is in close contact with diseased areas in neurological disorders, it is an important source of material in the search for molecular biomarkers. However, sample handling for CSF collected from patients in a clinical setting might not always be adequate for use in proteomics and metabolomics studies....
article 2011
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Stoop, M.P. (author), Coulier, L. (author), Rosenling, T. (author), Shi, S. (author), Smolinska, A.M. (author), Buydens, L. (author), Ampt, K. (author), Stingl, C. (author), Dane, A. (author), Muilwijk, B. (author), Luitwieler, R.L. (author), Sillevis Smitt, P.A.E. (author), Hintzen, R.Q. (author), Bischoff, R. (author), Wijmenga, S.S. (author), Hankemeier, T. (author), van Gool, A.J. (author), Luider, T.M. (author), TNO Kwaliteit van Leven (author)
The analysis of cerebrospinal fluid (CSF) is used in biomarker discovery studies for various neurodegenerative central nervous system (CNS) disorders. However, little is known about variation of CSF proteins and metabolites between patients without neurological disorders. A baseline for a large number of CSF compounds appears to be lacking. To...
article 2010
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van Dongen, W.D. (author), Coulier, L. (author), van Stee, L. (author), Koster, S. (author), Muilwijk, B. (author), Peters, R. (author), Zondervan-van den Beuken, E. (author), Rijk, R. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), TNO Kwaliteit van Leven (author)
article 2009
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van der Werf, M.J. (author), Overkamp, K.M. (author), Muilwijk, B. (author), Koek, M.M. (author), van der Werff van der - Vat, B.J.C. (author), Jellema, R.H. (author), Coulier, L. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Metabolomics is an emerging, powerful, functional genomics technology that involves the comparative non-targeted analysis of the complete set of metabolites in an organism. We have set-up a robust quantitative metabolomics platform that allows the analysis of 'snapshot' metabolomes. In this study, we have applied this platform for the...
article 2008
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Koek, M.M. (author), Muilwijk, B. (author), van Stee, L.L.P. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
article 2008
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Werf, M.J.v.d. (author), Overkamp, K.M. (author), Muilwijk, B. (author), Coulier, L. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Achieving metabolome data with satisfactory coverage is a formidable challenge in metabolomics because metabolites are a chemically highly diverse group of compounds. Here we present a strategy for the development of an advanced analytical platform that allows the comprehensive analysis of microbial metabolomes. Our approach started with in...
article 2007
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Koek, M.M. (author), Muilwijk, B. (author), van der Werf, M.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
An analytical method was set up suitable for the analysis of microbial metabolomes, consisting of an oximation and silylation derivatization reaction and subsequent analysis by gas chromatography coupled to mass spectrometry. Microbial matrixes contain many compounds that potentially interfere with either the derivatization procedure or analysis...
article 2006
Searched for: author:"Muilwijk, B."
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