Searched for: author%3A%22Morrison%2C+M.C.%22
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Arnoldussen, I.A.C. (author), Morrison, M.C. (author), Wiesmann, M. (author), van Diepen, J.A. (author), Worms, N. (author), Voskuilen, M. (author), Verweij, V. (author), Greenen, B. (author), Pujol Gauldo, N. (author), van der Logt, L. (author), Gross, G. (author), Verschuren, L. (author), Kleemann, R. (author), Kiliaan, A.J. (author)
Background. Milk-fat globule membrane (MFGM) is a complex structure secreted by the mammary gland and present in mammalian milk. MFGM contains lipids and glycoproteins as well as gangliosides, which may be involved in myelination processes. Notably, myelination and thereby white matter integrity are often altered in obesity. Furthermore, MFGM...
article 2022
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Morrison, M.C. (author), Gart, E. (author), van Duyvenvoorde, W. (author), Snabel, J. (author), Nielsen, M.J. (author), Leeming, D.J. (author), Menke, A. (author), Kleemann, R. (author)
The development of non-alcoholic steatohepatitis (NASH) has been associated with alterations in gut microbiota composition and reduced gut barrier function. Akkermansia muciniphila is a gut microbe that is thought to have health-promoting properties, including the ability to improve gut barrier function and host metabolism, both when...
article 2022
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Komninos, D. (author), Ramos, L. (author), van der Heijden, G.W. (author), Morrison, M.C. (author), Kleemann, R. (author), van Herwaarden, A.E. (author), Kiliaan, A.J. (author), Arnoldussen, I.A.C. (author)
Obesity can disturb spermatogenesis and subsequently affect male fertility and reproduction. In our study, we aim to elucidate at which cellular level of adult spermatogenesis the detrimental effects of obesity manifest. We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr−/−.Leiden) mice, and studied...
article 2022
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Martínez-Arranz, I. (author), Bruzzone, C. (author), Noureddin, M. (author), Gil-Redondo, R. (author), Mincholé, I. (author), Bizkarguenaga, M. (author), Arretxe, E. (author), Iruarrizaga-Lejarreta, M. (author), Fernández-Ramos, D. (author), Lopitz-Otsoa, F. (author), Mayo, R. (author), Embade, N. (author), Newberry, E. (author), Mittendorf, B. (author), Izquierdo-Sánchez, L. (author), Smid, V. (author), Arnold, J. (author), Iruzubieta, P. (author), Pérez Castaño, Y. (author), Krawczyk, M. (author), Marigorta, U.M. (author), Morrison, M.C. (author), Kleemann, R. (author), Martín-Duce, A. (author), Hayardeny, L. (author), Vitek, L. (author), Bruha, R. (author), Aller de la Fuente, R. (author), Crespo, J. (author), Romero-Gomez, M. (author), Banales, J.M. (author), Arrese, M. (author), Cusi, K. (author), Bugianesi, E. (author), Klein, S. (author), Lu, S.C. (author), Anstee, Q.M. (author), Millet, O. (author), Davidson, N.O. (author), Alonso, C. (author), Mato, J.M. (author)
Background and Aims: We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors. Approach and Results: We analyzed serum metabolome from 1154 individuals with biopsy-proven NAFLD, and from four mouse models of NAFLD...
article 2022
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Mueller, A.M. (author), Kleemann, R. (author), Gart, E. (author), van Duyvenvoorde, W. (author), Verschuren, L. (author), Caspers, M. (author), Menke, A. (author), Krömmelbein, N. (author), Salic, K. (author), Burmeister, Y. (author), Seilheimer, B. (author), Morrison, M.C. (author)
Background: Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder that is characterised by dysfunctional lipid metabolism and cholesterol homeostasis, and a related chronic inflammatory response. NAFLD has become the most common cause of chronic liver disease in many countries, and its prevalence continues to rise in...
article 2021
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Gart, E. (author), van Duyvenvoorde, W. (author), Toet, K. (author), Caspers, M.P.M. (author), Verschuren, L. (author), Nielsen, M.J. (author), Leeming, D.J. (author), Lima, E.S. (author), Menke, A. (author), Hanemaaijer, R. (author), Keijer, J. (author), Salic, K. (author), Kleemann, R. (author), Morrison, M.C. (author)
In obesity-associated non-alcoholic steatohepatitis (NASH), persistent hepatocellular damage and inflammation are key drivers of fibrosis, which is the main determinant of NASH-associated mortality. The short-chain fatty acid butyrate can exert metabolic improvements and anti-inflammatory activities in NASH. However, its effects on NASH...
article 2021
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Gart, E. (author), Salic, K. (author), Morrison, M.C. (author), Caspers, M. (author), van Duyvenvoorde, W. (author), Heijnk, M. (author), Giera, M. (author), Bobeldijk-Pastorova, I. (author), Keijer, J. (author), Storsve, A.B. (author), Hals, P.A. (author), Kleemann, R. (author)
The development of obesity is characterized by the metabolic overload of tissues and subsequent organ inflammation. The health effects of krill oil (KrO) on obesity-associated inflammation remain largely elusive, because long-term treatments with KrO have not been performed to date. Therefore, we examined the putative health effects of 28 weeks...
article 2021
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Tengeler, A.C. (author), Gart, E. (author), Wiesmann, M. (author), Arnoldussen, I.A.C. (author), Verschuren, L. (author), van Duyvenvoorde, W. (author), Hoogstad, M. (author), Dederen, P.J. (author), Verweij, V. (author), Geenen, B. (author), Kozicz, T. (author), Kleemann, R. (author), Morrison, M.C. (author), Kiliaan, A.J. (author)
The obesity epidemic increases the interest to elucidate impact of short‐chain fatty acids on metabolism, obesity, and the brain. We investigated the effects of propionic acid (PA) and caproic acid (CA) on metabolic risk factors, liver and adipose tissue pathology, brain function, structure (by MRI), and gene expression, during obesity...
article 2020
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van Broekhoven, A. (author), Krijnen, P.A.J. (author), Fuijkschot, W.W. (author), Morrison, M.C. (author), Zethof, I.P.A. (author), van Wieringen, W.N. (author), Smulders, Y.M. (author), Niessen, H.W.M. (author), Vonk, A.B.A. (author)
Background Recently, it was shown that 12 weeks of lipopolysacharide (LPS) administration to non‐atherosclerotic mice induced thickening of the aortic heart valve (AV). Whether such effects may also occur even earlier is unknown. As most patients with AV stenosis also have atherosclerosis, we studied the short‐term effect of LPS on the AVs in an...
article 2019
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Jacobs, S.A.H. (author), Gart, E. (author), Vreeken, D. (author), Franx, B.A.A. (author), Wekking, L. (author), Verweij, V.G.M. (author), Worms, N. (author), Schoemaker, M.H. (author), Gross, G. (author), Morrison, M.C. (author), Kleemann, R. (author), Arnoldussen, I.A.C. (author), Kiliaan, A.J. (author)
Background: Sex-specific differences play a role in metabolism, fat storage in adipose tissue, and brain structure. At juvenile age, brain function is susceptible to the effects of obesity; little is known about sex-specific differences in juvenile obesity. Therefore, this study examined sex-specific differences in adipose tissue and liver of...
article 2019
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Gart, E. (author), Souto Lima, E. (author), Schuren, F, (author), de Ruiter, C.G.F. (author), Attema, J. (author), Verschuren, L. (author), Keijer, J. (author), Salic, K. (author), Morrison, M.C. (author), Kleemann, R. (author)
Development of non-alcoholic fatty liver disease (NAFLD) is linked to obesity, adipose tissue inflammation, and gut dysfunction, all of which depend on diet. So far, studies have mainly focused on diet-related fecal microbiota changes, but other compartments may be more informative on host health. We present a first systematic analysis of...
article 2019
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Kozijn, A.E. (author), Gierman, L.M. (author), van der Ham, F. (author), Mulder, P. (author), Morrison, M.C. (author), Kühnast, S. (author), van der Heijden, R.A. (author), Stavro, P.M. (author), van Koppen, A. (author), Pieterman, E.J. (author), van den Hoek, A.M. (author), Kleemann, R. (author), Princen, H.M.G. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author), Zuurmond, A.M. (author), Bobeldijk, I. (author), Weinans, H. (author), Stoop, R. (author)
Objective. Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation in the knees of mice from different genetic backgrounds in which a metabolic phenotype was...
article 2018
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Fuijkschot, W.W. (author), Morrison, M.C. (author), Zethof, I.P.A. (author), Krijnen, P.A.J. (author), Kleemann, R. (author), Niessen, H.W.M. (author), Smulders, Y.M. (author)
Background and Aims: Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intraplaque inflammation. We evaluated whether...
article 2018
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Woudstra, L. (author), Meinster, E. (author), van Haren, L. (author), Kay, A.M. (author), Kooman, M. (author), Belien, J.A.M. (author), Morrison, M.C. (author), van Rossum, A.C. (author), Helder, M.N. (author), Juffermans, J.M. (author), Niessen, H.W.M. (author), Krijnen, P.A.J. (author)
Background aims. After a myocardial infarction (MI) atherosclerosis is accelerated leading to destabilization of the atherosclerotic plaque. mesenchymal stromal cells are a promising therapeutic option for atherosclerosis. Previously, we demonstrated a novel stem cell delivery technique, with adipose stem cells coupled to microbubbles (i.e.,...
article 2018
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Morrison, M.C. (author), Verschuren, L. (author), Salic, K. (author), Verhij, J. (author), Menke, A. (author), Wielinga, P.Y. (author), Iruarrizaga-Lejarretts, M. (author), Gole, L. (author), Yu, W.M. (author), Turner, S. (author), Caspers, M.P.M. (author), Martinez-Arranz, I. (author), Pieterman, E. (author), Stoop, R. (author), van Koppen, A. (author), van den Hoek, A.M. (author), Mato, J.M. (author), Hanemaaijer, R. (author), Alonso, C. (author), Kleemann, R. (author)
Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value in studies of therapeutic interventions in the process of NASH/fibrosis. We investigated the representation of molecular disease...
article 2018
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Morrison, M.C. (author), Kleemann, R. (author), van Koppen, A. (author), Hanemaaijer, R. (author), Verschuren, L. (author)
Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic mechanisms requires the use of pre-clinical...
article 2018
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van Koppen, A. (author), Verschuren, L. (author), van den Hoek, A.M. (author), Verheij, J. (author), Morrison, M.C. (author), Li, K. (author), Nagabukuro, H. (author), Costessi, A. (author), Caspers, M.P.M. (author), van den Broek, T.J. (author), Sagartz, J. (author), Kluft, C. (author), Beysen, C. (author), Emson, C. (author), van Gool, A.J. (author), Goldschmeding, R. (author), Stoop, R. (author), Bobeldijk-Pastorova, I. (author), Turner, S.M. (author), Hanauer, G. (author), Hanemaaijer, R. (author)
Background & Aims: The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynamics of key molecular processes involved in NASH and to rank early markers for...
article 2017
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Schoemaker, M.H. (author), Kleemann, R. (author), Morrison, M.C. (author), Verheij, J. (author), Salic, K. (author), van Tol, E.A.F. (author), Kooistra, T. (author), Wielinga, P.Y. (author)
Background: Obesity frequently associates with the development of non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. Chronic inflammation in white adipose tissue (WAT) seems to be an important driver of these manifestations. Objective: This study investigated a combination of an extensively hydrolyzed casein (eHC), docosahexaenoic...
article 2017
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Zimmer, M. (author), Bista, P. (author), Benson, E.L. (author), Lee, D.Y. (author), Liu, F. (author), Picarella, D. (author), Vega, R.B. (author), Vu, C.B. (author), Yeager, M. (author), Ding, M. (author), Liang, G. (author), Horton, J.D. (author), Kleemann, R. (author), Kooistra, T. (author), Morrison, M.C. (author), Wielinga, P.Y. (author), Milne, J.C. (author), Jirousek, M.R. (author), Nichol, A.J. (author)
CAT-2003 is a novel conjugate of eicosapentaenoic acid (EPA) and niacin designed to be hydrolyzed by fatty acid amide hydrolase to release EPA inside cells at the endoplasmic reticulum. In cultured liver cells, CAT-2003 blocked the maturation of sterol regulatory element-binding protein (SREBP)-1 and SREBP-2 proteins and decreased the expression...
article 2017
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Morrison, M.C. (author), Yakala, G.K. (author), Liang, W. (author), Wielinga, P.Y. (author), Salic, K. (author), van Koppen, A. (author), Tomar, T. (author), Kleemann, R. (author), Heeringa, P. (author), Kooistra, T. (author)
Obesity-related albuminuria is associated with decline of kidney function and is considered a first sign of diabetic nephropathy. Suggested factors linking obesity to kidney dysfunction include low-grade inflammation, insulin resistance and adipokine dysregulation. Here, we investigated the effects of two pharmacological compounds with...
article 2017
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