document

Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of oatp1b1s

van de Steeg, E. (author), Greupink, R. (author), Schreurs, M. (author), Nooijen, I.H.G. (author), Verhoeck, K.C.M. (author), Hanemaaijer, R. (author), Ripken, D. (author), Monshouwer, M. (author), Vlaming, M.L.H. (author), DeGroot, J. (author), Verwei, M. (author), Russel, F.G.M. (author), Huisman, M.T. (author), Wortelboer, H.M. (author)

Organic anion-transporting polypeptide 1B1 (OATP1B1) is an important hepatic uptake transporter, of which the polymorphic variant OATP1B1*15 (Asn130Asp and Val174Ala) has been associated with decreased transport activity. Rosuvastatin is an OATP1B1 substrate and often concomitantly prescribed with oral antidiabetics in the clinic. The aim of...

article 2013

document

Toxicokinetics and metabolism

Coecke, S. (author), Blaauboer, B.J. (author), Elaut, G. (author), Freeman, S. (author), Freidig, A. (author), Gensmantel, N. (author), Hoet, P. (author), Kapoulas, V.M. (author), Ladstetter, B. (author), Langley, G. (author), Leahy, D. (author), Mannens, G. (author), Meneguz, A. (author), Monshouwer, M. (author), Nemery, B. (author), Pelkonen, O. (author), Pfaller, W. (author), Prieto, P. (author), Proctor, N. (author), Rogiers, V. (author), Rostami-Hodjegan, A. (author), Sabbioni, E. (author), Steiling, W. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)

article 2005

document

Direct cell-to-cell contact between Kupffer cells and hepatocytes augments endotoxin-induced hepatic injury

Hoebe, K.H.N. (author), Witkamp, R.F. (author), Fink-Gremmels, J. (author), van Miert, A.S.J.P.A.M. (author), Monshouwer, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

This study focuses on the importance of direct contact between Kupffer cells (KCs) and hepatocytes (HCs) during the hepatic inflammatory response using an in vitro approach. The lipopolysaccharide (LPS)-induced inflammatory response in monocultures of porcine HCs and KCs were compared with cocultures prepared either with direct contact between...

article 2001

document

Differential effects of pentoxifylline on the hepatic inflammatory response in porcine liver cell cultures increase in inducible nitric oxide synthase expression

Centraal Instituut voor Voedingsonderzoek TNO (author), Hoebe, K.H.N (author), Gonzalez-Ramon, N. (author), Nijmeijer, S.M. (author), Witkamp, R.F. (author), van Leengoed, L.A.M.G (author), van Miert, A.S.J.P.A.M (author), Monshouwer, M. (author)

Pentoxifylline (PTX) has been shown to exert hepatoprotective effects in various liver injury models. However, little information is available about the effect of PTX on the hepatic acute phase response. In the present study, the effect of PTX on a lipopolysaccharide (LPS)-induced acute phase response in primary porcine liver cell cultures was...

article 2001

document

Cytochromes and cytokines : changes in drug disposition in animals during an acute phase response : a mini review

Monshouwer, M. (author), Witkamp, R.F. (author)

article 2000

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Suppression of the acute inflammatory response of porcine alveolar- and liver macrophages

Izeboud, C.A. (author), Monshouwer, M. (author), Witkamp, R.F. (author), van Miert, A.S.J. (author), TNO Voeding (author)

During infection and inflammation drug disposition and hepatic metabolism are markedly affected in mammals. Pro-inflammatory mediators play an important role in the suppression of (cytochrome-P450-mediated) drug metabolism. Inflammatory mediators like cytokines, nitric oxide (NO), reactive oxygen species (ROS) and eicosanoids are released by...

article 2000

document

Signal transduction in inflammatory processes, current and future therapeutic targets: A mini review

Witkamp, R. (author), Monshouwer, M. (author)

article 2000

document

Cocultures of porcine hepatocytes and kupffer cells as an improved in vitro model for the study of hepatotoxic compounds

TNO Pharma (author), Hoebe, K.H.N. (author), Monshouwer, M. (author), Witkamp, R.F. (author), Fink-Gremmels, J. (author), van Miert, A.S.J.P.A.M. (author)

article 2000

document

The β-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-α and IL-6 in vitro and in vivo

Izeboud, C.A. (author), Monshouwer, M. (author), van Miert, A.S.J.P.A.M. (author), Witkamp, R.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Objective and Design: To investigate the suppressive effects of the β-agonist clenbuterol on the release of TNF-α and IL-6 in a lipopolysaccharide (LPS)-model of inflammation, both in vitro and in vivo. Material and Subjects: Human U-937 cell line (monocyte-derived macrophages), and male Wistar rats (200-250 g). Treatment: U-937 macrophages were...

article 1999

document

Participation of beta-adrenergic receptors on macrophages in modulation of lps-induces cytokine release

Izeboud, C.A. (author), Mocking, J.A.J. (author), Monshouwer, M. (author), van Miert, A.S.J.P.A.M. (author), Witkamp, R.F. (author)

article 1999

document

The beta-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-inducedproduction of TNF-alpha and IL-6 in vitro and in vivo

Izeboud, C.A. (author), Monshouwer, M. (author), van Miert, A.S.J.P.A.M. (author), Witkamp, R.F. (author)

article 1999

document

Participation of β-adrenergic receptors on macrophages in modulation of LPS-induced cytokine release

Izeboud, C.A. (author), Mocking, J.A.J. (author), Monshouwer, M. (author), van Miert, A.S.J.P.A.M. (author), Witkamp, R.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

For several years it is known that β-adrenergic receptor agonists have anti-inflammatory effects. However, little is known about the role of β- adrenergic receptors on macrophages in the modulation of cytokine production by β-agonists during inflammation. In this study, the presence of β- receptors on PMA-differentiated U937 human macrophages,...

article 1999

document

Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes

Monshouwer, M. (author), van 't Klooster, G.A.E. (author), Nijmeijer, S.M. (author), Witkamp, R.F. (author), van Miert, A.S.J.P.A.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Despite the fact that pigs are increasingly used in pharmacological and toxicological studies, knowledge on the enzymes which metabolize xenobiotics, in particular cytochrome P450 (CYP) enzymes, in pigs is still very limited. Primary cultures of pig hepatocytes were used to characterize CYP enzymes. The characterization was performed at the...

article 1998

document

Acute-phase response induced down-regulation of hepatic drug metabolism in pigs

Monshouwer, M. (author), Witkamp, R.F. (author), Nijmeijer, S.M. (author), van Miert, A.S.J.P.A.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

article 1998

document

Pharmacokinetics in vivo and in vitro in swine

Witkamp, R.F. (author), Monshouwer, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

article 1998

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Suppression of cytochrome P450- and UDP glucuronosyl transferase-dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes

Monshouwer, M. (author), Witkamp, R.F. (author), Nijmeijer, S.M. (author), van Amsterdam, J.G. (author), van Miert, A.S.J.P.A.M. (author), TNO Voeding (author)

article 1996

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Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450

Monshouwer, M. (author), Mclellan, R.A. (author), Delaporte, E. (author), Witkamp, R.F. (author), van Miert, A.S.J.P.A.M. (author), Renton, K.W. (author), TNO Voeding (author)

article 1996

document

A lipopolysaccharide-induced acute phase response in the pig is associated with decrease in hepatic cytochrome P450-mediated drug metabolism

Monshouwer, M. (author), Witkamp, R.F. (author), Nijmeijer, S.M. (author), van Leengoed, L.A.M.G. (author), Vernooy, H.C.M. (author), Verheijden, J.H.M. (author), van Miert, A.S.J.P.A.M. (author), TNO Voeding (author)

article 1996

document

A Lipopolysaccharide induced acute phase response in the pig inhibits hepatic cytochrome P450-mediated drug metabolism

Monshouwer, M. (author), Witkamp, R.F. (author), Nijmeijer, S.M. (author), van Leengoed, L.A.M.G. (author), Vernooy, H.C.M. (author), Verheijden, J.H.M. (author), van Miert, A.S.J.P.A.M. (author), TNO Voeding (author)

article 1996