General report on Roadmap on Carcinogens Challenge 4.2: Process Generated Carcinogens

The Roadmap on Carcinogens aims to create awareness on occupational exposure to carcinogens, and ultimately provide innovative approaches to reduce exposure. One of the challenges of this roadmap (Challenge 4.2) is to get more grip on carcinogens created as a by-product during a work process, so called processgenerated carcinogens (PGCs). As...

General report on Roadmap on Carcinogen Challenge 4.3: Safe Working Procedures

The Roadmap on Carcinogens aims to create awareness on occupational exposure to carcinogens, and ultimately provide innovative approaches to reduce exposure. One of the challenges of this roadmap (Challenge 4.3) is to gather results, bring together stakeholders and promote the development of SWPs. The current report aims to summarize the status...

Updated full range of Eliciting Dose values for Cow's milk for use in food allergen risk assessment

Access to Eliciting Doses (ED) for allergens enables advanced food allergen risk assessment. Previously, the full ED range for 14 allergenic foods, including milk, and recommendations for their use were provided (Houben et al., 2020). Additional food challenge studies with cow's milk-allergic patients added 247 data points to the original...

A systematic comparison of food intake data of the United States and the Netherlands for food allergen risk assessment

Methods to determine the risk of unintended allergen presence related to the dispersion of allergenic food particles in food production areas

Allergenic food particles (typically ~0.5–5 mm) may unintentionally end up in food products during production and can pose a risk for the allergic consumer. A single particle can provoke allergic symptoms in an allergic consumer when the dose of allergenic protein exceeds minimal eliciting doses. However, there is a lack of fundamental knowledge...

Updated population minimal eliciting dose distributions for use in risk assessment of 14 priority food allergens

Food allergy and allergen management are important global public health issues. In 2011, the first iteration of our allergen threshold database (ATDB) was established based on individual NOAELs and LOAELs from oral food challenge in roughly 1750 allergic individuals. Population minimal eliciting dose (EDp) distributions based on this dataset...

Seeking Windows of Opportunity to Shape Lifelong Immune Health A Network-Based Strategy to Predict and Prioritize Markers of Early Life Immune Modulation

A healthy immune status is strongly conditioned during early life stages. Insights into the molecular drivers of early life immune development and function are prerequisite to identify strategies to enhance immune health. Even though several starting points for targeted immune modulation have been identified and are being developed into...

Full range of population Eliciting Dose values for 14 priority allergenic foods and recommendations for use in risk characterization

Previously, we published selected Eliciting Dose (ED) values (i.e. ED01 and ED05 values) for 14 allergenic foods, predicted to elicit objective allergic symptoms in 1% and 5%, respectively, of the allergic population (Remington et al., 2020). These ED01 and ED05 values were specifically presented and discussed in the context of establishing...

A Family of Water-Immiscible, Dipolar Aprotic, Diamide Solvents from Succinic Acid

Three dipolar aprotic solvents were designed to possess high dipolarity and low toxicity: N,N,N′,N′-tetrabutylsuccindiamide (TBSA), N,N′-diethyl-N,N′-dibutylsuccindiamide (EBSA), and N,N′-dimethyl-N,N′-dibutylsuccindiamide (MBSA). They were synthesized catalytically by using a K60 silica catalyst in a solventless system. Their water...