document

Enzymology and regulation of the atropine metabolism in Pseudomonas putida

Gezondheidsorganisatie TNO Medisch Biologisch Laboratorium TNO (author), Stevens, W.F. (author)

The breakdown of a chemical compound in living organisms is accomplished usually by a sequence of enzyme catalyzed reactions. As a result, such a compound is broken down by a fixed pattern, the metabolic pathway. In most cases, the cells in an organism are able to control the synthesis and activity of the enzymes involved. In this way, the cells...

doctoral thesis 2019

document

Determinants of cisplatin sensitivity in head and neck cancer

Medisch Biologisch Laboratorium TNO (author), Welters, M.J.P. (author)

doctoral thesis 1998

document

V. Functions of S-layers

Medisch Biologisch Laboratorium TNO (author), Beveridge, T.J. (author), Pouwels, P.H. (author), Sára, M. (author), Kotiranta, A. (author), Lounatmaa, K. (author), Kari, K. (author), Kerosuo, E. (author), Haapasalo, M. (author), Egelseer, E.M. (author), Schocher, I. (author), Sleytr, U.B. (author), Morelli, L. (author), Callegari, M.L. (author), Nomellini, J.F. (author), Bingle, W.H. (author), Smit, J. (author), Leibovitz, E. (author), Lemaire, M. (author), Miras, I. (author), Salamitou, S. (author), Béguin, P. (author), Ohayon, H. (author), Gounon, P. (author), Matuschek, M. (author), Sahm, K. (author), Bahl, H. (author), Grogono-Thomas, R. (author), Dworkin, J. (author), Blaser, M.J. (author), Woodland, R.M. (author), Newell, D.G. (author), Kessel, M. (author), Koval, S.F. (author)

Although S-layers are being increasingly identified on Bacteria and Archaea, it is enigmatic that in most cases S-layer function continues to elude us. In a few instances, S-layers have been shown to be virulence factors on pathogens (e.g. Campylobacter fetus ssp. fetus and Aeromonas salmonicida), protective against Bdellovibrio, a depository...

article 1997

document

Heterogeneity of pituitary follicula-stellate cells: Implications for iterleukin-6 production and accessory function in vitro

Medisch Biologisch Laboratorium TNO (author), Allaerts, W. (author), Jeucken, P.H.M. (author), Debets, R. (author), Hoefakker, S. (author), Claassen, E. (author), Drexhage, H.A. (author)

The population of folliculo-stellate (FS) cells of the rat anterior pituitary has been shown to be ultrastructurally and immunohistochemically heterogeneous. Based on the overlap of ultrastructural characteristics, the localization in the anterior pituitary and the co-expression within the same cel of the S-100 protein (a marker for FS cells)...

article 1997

document

Intercomparison of measurement techniques used in radon exposure facilities for animals in Europe

Medisch Biologisch Laboratorium TNO (author), Strong, J.C. (author), Morlier, J.P. (author), Monchaux, G. (author), Bartstra, R.W. (author), Groen, J.S. (author), Baker, S.T. (author)

The biological effects of exposure to radon and its progeny are being studied in animals by three laboratories in Europe. The facilities used for such exposures are described, together with the methods used to estimate radon progeny concentrations and the activity deposited in the lungs of exposed animals. As the facilities and methods vary, a...

article 1996

document

Heterologous gene expression in Lactobacillus

Posno, M. (author), Kottenhagen, M. (author), Lokman, B.C. (author), Jore, J. (author), Leer, R.J. (author), Pouwels, P.H. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)

conference paper 1994

document

Structural and functional analysis of plasmid vectors for Lactobacillus

Leer, R.J. (author), van Luijk, N. (author), Posno, M. (author), Pouwels, P.H. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)

conference paper 1994

document

Occupational skin exposure to chemical substances: Workshop summary

Marquart, H. (author), Brouwer, D.H. (author), van Rooij, J.G.M. (author), Medisch Biologisch Laboratorium TNO (author)

article 1994

document

Strategies for the over-production of fungal proteins in Aspergillus

van den Hondel, C.A.M.J.J. (author), Punt, P.J. (author), van Gorcom, R.F.M. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)

conference paper 1994

document

Heterologous gene expression in Aspergillus

van Gorcom, R.F.M. (author), Punt, P.J. (author), van den Hondel, C.A.M.J.J. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)

bookPart 1994

document

Genetic engineering of Lactobacilli, Leuconostocs, and Streptococcus thermophilus

Mercenier, A. (author), Pouwels, P.H. (author), Chassy, B.M. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)

bookPart 1994

document

Schade mens: Veilig omgaan met bestrijdingsmiddelen

van Hemmen, J. (author), Medisch Biologisch Laboratorium TNO (author)

article 1994

document

The effect of multiple copies of the upstream region of the Aspergillus niger glucoamylase-encoding gene on expression

Verdoes, J.C. (author), Punt, P.J. (author), Stouthamer, A.H. (author), van den Hondel, C.A.M.J.J. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)

The regulation of transcription of the glucoamylase-encoding gene (glaA) of Aspergillus niger was studied. To facilitate this study a reporter strain containing a fusion of the glaA promoter (P(glaA)) of A. niger to the β- glucuronidase-encoding gene (uidA) of Escherichia coli was constructed. To analyze whether regulatory proteins are involved...

article 1994

document

A personal sampler for inhalable mixed-phase aerosols: Modification to an existing sampler and validation test with three pesticides

Brouwer, D.H. (author), Ravensberg, J.C. (author), de Kort, W.L.A.M. (author), van Hemmen, J.J. (author), Medisch Biologisch Laboratorium TNO (author)

article 1994

document

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory

Foy, T.M. (author), Laman, J.D. (author), Ledbetter, J.A. (author), Aruffo, A. (author), Claassen, E. (author), Noelle, R.J. (author), Medisch Biologisch Laboratorium TNO (author)

gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the generation of antibody responses to T-dependent (TD) antigens. Treatment of mice with anti-gp39 in vivo inhibits both primary and secondary antibody formation to TD, but not T-independent antigens. However, the role of this receptor-ligand pair in the...

article 1994

document

Estimation of long-term exposure to pesticides

Brouwer, D.H. (author), Brouwer, E.J. (author), van Hemmen, J.J. (author), Medisch Biologisch Laboratorium TNO (author)

article 1994

document

Exposure to pesticides during and after application in the cultivation of chrysanthemums in greenhouses: Health risk and risk management

Brouwer, D.H. (author), de Vreede, J.A.F. (author), de Haan, M. (author), van de Vijver, L. (author), Veerman, M. (author), Stevenson, H. (author), van Hemmen, J.J. (author), Medisch Biologisch Laboratorium TNO (author)

article 1994

document

Application of stereology and morphometry on synapses and neurons in the hippocampus of ageing rats: an illustration of problems and solutions : Toepassing van stereologie en morfometrie op synapsen en neuronen in de hippocampus van verouderende ratten : een illustratie van problemen en oplossingen

Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author), de Groot, D.M.G. (author)

doctoral thesis 1994

document

Mutagens and polycyclic aromatic hydrocarbons in ambient airborne particles

Gezondheidsorganisatie TNO TNO Voeding Medisch Biologisch laboratorium TNO (author), de Raat, W.K. (author)

doctoral thesis 1994

document

The role of T-cell activation in human retroviral expression

Medisch Biologisch Laboratorium TNO (author), Copeland, K.F.T. (author)

doctoral thesis 1994