Searched for: author:"Marquart, H."
(1 - 20 of 47)

Pages

document
Franken, R. (author), Shandilya, N. (author), Marquart, H. (author), McNally, K. (author), Fransman, W. (author)
Measured data are generally preferred to modelled estimates of exposure. Grouping and read-across is already widely used and accepted approach in toxicology, but an appropriate approach and guidance on how to use existing exposure measurement data on one substance and work situation for another substance and/or work situation is currently not...
article 2020
document
Goede, H.A. (author), McNally, K. (author), Gorce, J.P. (author), Marquart, H. (author), Warren, N.D. (author), Fransman, W. (author), Tischer, M. (author), Schinkel, J. (author)
This article describes the development of a mechanistic model for underpinning the dermal Advanced REACH Tool (dART), an extension of the existing ART model and its software platform. It was developed for hand exposure to low volatile liquids (vapour pressure ≤ 10 Pa at 20°C) including solids-in-liquid products. The model is based on an existing...
article 2019
document
Marquart, H. (author), Franken, R. (author), Goede, H. (author), Fransman, W. (author), Schinkel, J. (author)
The ECETOC TRA model (presently version 3.1) is often used to estimate worker inhalation and dermal exposure in regulatory risk assessment. The dermal model in ECETOC TRA has not yet been validated by comparison with independent measured exposure levels. This was the goal of the present study. Measured exposure levels and relevant contextual...
article 2017
document
Clausen, P.A. (author), Spaan, S. (author), Brouwer, D.H. (author), Marquart, H. (author), le Feber, M. (author), Engel, R. (author), Geerts, L. (author), Jensen, K.A. (author), Kofoed-Sørensen, V. (author), Hansen, B. (author), de Brouwere, K. (author)
The aim of this work was to identify the key mechanisms governing transport of organic chemical substances from consumer articles to cotton wipes. The results were used to establish a mechanistic model to improve assessment of dermal contact exposure. Four types of PVC flooring, 10 types of textiles and one type of inkjet printed paper were used...
article 2016
document
Buist, H. (author), Aldenberg, T. (author), Batke, M. (author), Escher, S. (author), Kühne, R. (author), Marquart, H. (author), Pauné, E. (author), Rorije, E. (author), Schüürmann, G. (author), Kroese, D.E. (author)
Risk assessment of chemicals usually implies data evaluation of in vivo tests in rodents to conclude on 31 their hazards. The FP7 European project OSIRIS has developed integrated testing strategies (ITS) for rel- 32 evant toxicological endpoints to avoid unnecessary animal testing and thus to reduce time and costs. This 33 paper describes the...
article 2013
document
Marquart, H. (author), Schneider, T. (author), Goede, H. (author), Tischer, M. (author), Schinkel, J. (author), Warren, N. (author), Fransman, W. (author), Spaan, S. (author), van Tongeren, M. (author), Kromhout, H. (author), Tielemans, E. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
There is a large variety of activities in workplaces that can lead to emission of substances. Coding systems based on determinants of emission have so far not been developed. In this paper, a system of Activity Classes and Activity Subclasses is proposed for categorizing activities involving chemical use. Activity Classes share their so-called ...
article 2011
document
Marquart, H. (author), Meijster, T. (author), van de Bovenkamp, M. (author), ter Burg, W. (author), Spaan, S. (author), van Engelen, J. (author)
Within the REACH framework, but alsowithin OECD, there is understanding that for reasons of animal welfare, costs and logistics, it is important to limit the number of tests to be conducted. Exposure-based waiving (EBW) is a potentially important element in testing strategies. This publication describes criteria for exposure- based waiving as...
article 2011
document
Verbist, K., (author), Marquart, H., (author), Heussen, H., (author), Schinkel, J., (author), West, J., (author), Fransman, W., (author), van Niftrik, M, (author), Tielemans, E. (author)
article 2011
document
Spaan, S. (author), Terwoert, J. (author), Marquart, H. (author), Meijster, T. (author)
report 2011
document
Spaan, S. (author), Terwoert, J. (author), Marquart, H. (author), Meijster, T. (author)
report 2011
document
Vermeire, Th. (author), van de Bovenkamp, M. (author), Bruinen de Bruin, Y. (author), Delmaar, Ch. (author), van Engelen, J. (author), Escher, S. (author), Marquart, H. (author), Meijster, T. (author), TNO Kwaliteit van Leven (author)
article 2010
document
Vink, S.R. (author), Mikkers, J. (author), Bouwman, T. (author), Marquart, H. (author), Kroese, E.D. (author), TNO Kwaliteit van Leven (author)
REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in substances to be registered under REACH....
article 2010
document
Schinkel, J. (author), Fransman, W. (author), Heussen, H. (author), Kromhout, H. (author), Marquart, H. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
Objectives: For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not. The Stoffenmanager is mentioned as a first tier approach in the REACH guidance. In an attempt to...
article 2010
document
van Hemmen, J.J. (author), Marquart, H. (author), TNO Kwaliteit van Leven (author)
article 2009
document
TNO Kwaliteit van Leven (author), Marquart, H. (author), Heussen, H. (author), Le Feber, M. (author), Noy, D. (author), Tielemans, E. (author), Schinkel, J. (author), West, J. (author), van der Schaaf, D. (author)
In the scope of a Dutch programme to reinforce the working conditions policy on hazardous substances, an internet-based tool was developed to help small- and medium-sized companies to handle hazardous substances with more care. The heart of this tool, called the Stoffenmanager, is a risk banding scheme. It combines a hazard banding scheme...
article 2008
document
Marquart, H. (author), Northage, C. (author), Money, C. (author), TNO Kwaliteit van Leven (author)
The new European chemicals legislation REACH (Registration, Evaluation, Authorisation and restriction of Chemicals) requires the development of Exposure Scenarios describing the conditions and risk management measures needed for the safe use of chemicals. Such Exposure Scenarios should integrate considerations of both human health and the...
article 2007
document
TNO Kwaliteit van Leven (author), Marquart, H. (author), Heussen, H. (author), le Feber, M. (author), Noy, D. (author), Tielemans, E (author), Schinkel, J. (author), West, J. (author), van der Schaaf, D. (author)
In the scope of a Dutch programme to reinforce the working conditions policy on hazardous substances, an internet-based tool was developed to help small- and medium-sized companies to handle hazardous substances with more care. The heart of this tool, called the Stoffenmanager, is a risk banding scheme. It combines a hazard banding scheme...
report 2007
document
Marquart, H. (author), Warren, N.D. (author), Laitinen, J. (author), van Hemmen, J.J. (author), TNO Kwaliteit van Leven (author)
Dermal exposure needs to be addressed in regulatory risk assessment of chemicals. The models used so far are based on very limited data. The EU project RISKOFDERM has gathered a large number of new measurements on dermal exposure to industrial chemicals in various work situations, together with information on possible determinants of exposure....
article 2006
document
Warren, N.D. (author), Marquart, H. (author), Christopher, Y. (author), Laitinen, J. (author), van Hemmen, J.J. (author), TNO Kwaliteit van Leven (author)
The regulatory risk assessment of chemicals requires the estimation of occupational dermal exposure. Until recently, the models used were either based on limited data or were specific to a particular class of chemical or application. The EU project RISKOFDERM has gathered a considerable number of new measurements of dermal exposure together with...
article 2006
document
Marquart, H. (author), Visser, R. (author), Nossent, S. (author)
14e symposium Nederlandse Vereniging voor Arbeidshygiëne: Voorbij de grenzen van de arbeidshygiëne 27 en 28 april 2005, Zeist.
article 2005
Searched for: author:"Marquart, H."
(1 - 20 of 47)

Pages