Searched for: author%3A%22Luider%2C+T.M.%22
(1 - 8 of 8)
document
Paauw, A. (author), Scholz, H.C. (author), Mars-Groenendijk, R.H. (author), Dekker, L.J.M. (author), Luider, T.M. (author), Leeuwen, H.C. (author)
Meliodosis and glanders are both potential biological threat agents. Glanders is endemic in Southeast Asia and Northern Australia but occasionally found in other countries. Meliodosis is caused by Burkholderia pseudomallei, while glanders is caused by Burkholderia mallei. The diagnosis of these diseases is difficult because the clinical picture...
article 2023
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de Marchi, T. (author), Braakman, R.B.H. (author), Stingl, C. (author), van Duijn, M.M. (author), Smid, M. (author), Foekens, J.A. (author), Luider, T.M. (author), Martens, J.W.M. (author), Umar, A. (author)
article 2016
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Coulier, L. (author), Muilwijk, B. (author), Bijlsma, S. (author), Noga, M. (author), Tienstra, M. (author), Attali, A. (author), van Aken, H. (author), Suidgeest, E. (author), Tuinstra, T. (author), Luider, T.M. (author), Hankemeier, T. (author), Bobeldijk, I. (author)
Analysis of metabolites in biofluids by gas chromatography-mass spectrometry (GC-MS) after oximation and silylation is a key method in metabolomics. The GC-MS method was modified by a modified vial design and sample work-up procedure in order to make the method applicable to small volumes of cerebrospinal fluid (CSF), i. e. 10 μL, with similar...
article 2013
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Coulier, L. (author), Gerritsen, H. (author), van Kampen, J.J.A. (author), Reedijk, M.L. (author), Luider, T.M. (author), Osterhaus, A.D.M.E. (author), Gruters, R.A. (author), Brüll, L. (author)
Nucleoside reverse transcriptase inhibitors (NRTIs) are a key class of drugs for the treatment of HIV infection. NRTIs are intracellularly phosphorylated to their active triphosphate metabolites and compete with endogenous deoxynucleotides (dNTP) for substrate binding. It is therefore important to analyze the intracellular concentrations of...
article 2011
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Rosenling, T. (author), Stoop, M.P. (author), Smolinska, A. (author), Muilwijk, B. (author), Coulier, L. (author), Shi, S. (author), Dane, A. (author), Christin, C. (author), Suits, F. (author), Horvatovich, P.L. (author), Wijmenga, S.S. (author), Buydens, L.M.C. (author), Vreeken, R. (author), Hankemeier, T. (author), van Gool, A.J. (author), Luider, T.M. (author), Bischoff, R. (author)
BACKGROUND: Because cerebrospinal fluid (CSF) is in close contact with diseased areas in neurological disorders, it is an important source of material in the search for molecular biomarkers. However, sample handling for CSF collected from patients in a clinical setting might not always be adequate for use in proteomics and metabolomics studies....
article 2011
document
Stoop, M.P. (author), Coulier, L. (author), Rosenling, T. (author), Shi, S. (author), Smolinska, A.M. (author), Buydens, L. (author), Ampt, K. (author), Stingl, C. (author), Dane, A. (author), Muilwijk, B. (author), Luitwieler, R.L. (author), Sillevis Smitt, P.A.E. (author), Hintzen, R.Q. (author), Bischoff, R. (author), Wijmenga, S.S. (author), Hankemeier, T. (author), van Gool, A.J. (author), Luider, T.M. (author), TNO Kwaliteit van Leven (author)
The analysis of cerebrospinal fluid (CSF) is used in biomarker discovery studies for various neurodegenerative central nervous system (CNS) disorders. However, little is known about variation of CSF proteins and metabolites between patients without neurological disorders. A baseline for a large number of CSF compounds appears to be lacking. To...
article 2010
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Rosenling, T. (author), Slim, C.L. (author), Christin, C. (author), Coulier, L. (author), Shi, S. (author), Stoop, M.P. (author), Bosman, J. (author), Suits, F. (author), Horvatovich, P.L. (author), Stockhofe-Zurwieden, N. (author), Vreeken, R. (author), Hankemeier, T. (author), van Gool, A.J. (author), Luider, T.M. (author), Bischoff, R. (author), TNO Kwaliteit van Leven (author)
To standardize the use of cerebrospinal fluid (CSF) for biomarker research, a set of stability studies have been performed on porcine samples to investigate the influence of common sample handling procedures on proteins, peptides, metabolites and free amino acids. This study focuses at the effect on proteins and peptides, analyzed by applying...
article 2009
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Coulier, L. (author), van Kampen, J.J.A. (author), de Groot, R. (author), Gerritsen, H.W. (author), Bas, R.C. (author), van Dongen, W.D. (author), Brüll, L.P. (author), Luider, T.M. (author), TNO Kwaliteit van Leven (author), KvL (author)
Nucleoside reverse transcriptase inhibitors (NRTIs) are activated intracellularly to their triphosphate (TP) form, which compete with endogenous deoxynucleotide-triphosphates (dNTP) as substrate for HIV reverse transcriptase. The activity of NRTIs is thus described by the NRTI-TP to-dNTP ratio in relevant cell types. Therefore, we developed an...
article 2008
Searched for: author%3A%22Luider%2C+T.M.%22
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