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Meerhoff, G.F. (author), Vester, S.M. (author), Hesseling, P. (author), Klaassen, S.D. (author), Cornelissen, A.S. (author), Lucassen, P.J. (author), Joosen, J.A. (author)Organophosphate (OP) induced seizures are commonly treated with anticholinergics, oximes and anticonvulsants. Inhibition of P-glycoprotein (PgP) has been shown to enhance the efficacy of nerve agent treatment in soman exposed rats. In the present study, the promising effects of the PgP inhibitor tariquidar were investigated in more detail in...article 2018
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Joosen, M.J.A. (author), Jousma, E. (author), van den Boom, T.M. (author), Kuijpers, W.C. (author), Smit, A.B. (author), Lucassen, P.J. (author), van Helden, H.P.M. (author), TNO Defensie en Veiligheid (author)To date, treatment of organophosphate (OP) poisoning shows several shortcomings, and OP-victims might suffer from lasting cognitive deficits and sleep–wake disturbances. In the present study, long-term effects of soman poisoning on learning ability, memory and neurogenesis were investigated in rats, treated with the anticholinergic atropine and...article 2009
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Oitzl, M.S. (author), Mulder, M. (author), Lucassen, P.J. (author), Havekes, L.M. (author), Grootendorst, J. (author), de Kloet, E.R. (author), Gaubius Instituut TNO (author)Recent studies on apolipoprotein E (apoE) have stressed the importance of this protein in neuronal viability, especially in the hippocampal area. In the present study, we used the Morris water maze to assess spatial learning and memory in 6-month-old homozygous apoE-deficient and heterozygous control mice. The apoE status was checked by...article 1997
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- te Koppele, J.M. (author), Lucassen, P.J. (author), Sakkee, A.N. (author), van Asten, J.G. (author), Ravid, R. (author), Swaab, D.F. (author), van Bezooijen, C.F.A. (author), Gaubius Instituut TNO (author) article 1996