Searched for: author%3A%22Lijnen%2C+H.R.%22
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Gaubius Instituut TNO (author), Sakharov, D.V. (author), Lijnen, H.R. (author), Rijken, D.C. (author)
Staphylokinase (STA), a protein of bacterial origin, induces highly fibrin-specific thrombolysis both in human plasma in vitro and in pilot clinical trials. Using fluorescence microscopy, we investigated the spatial distribution of fluorescein isothiocyanate (FITC)-labeled STA during lysis of a plasma clot and its binding to purified fibrin...
article 1996
Lijnen, H.R. (author), Bachmann, F. (author), Collen, D. (author), Ellis, V. (author), Pannekoek, H. (author), Rijken, D.C. (author), Thorsen, S. (author), TNO Preventie en Gezondheid (author)
The fibrinolytic system consists of an inactive proenzyme, plasminogen, that is converted by plasminogen activators to the active enzyme, plasmin, that degrades fibrin. Two immunologically distinct plasminogen activators have been identified: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Plasminogen...
article 1994
Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Fleury, V. (author), Loyau, S. (author), Lijnen, H.R. (author), Nieuwenhuizen, W. (author), Angl├ęs-Cano, E. (author)
A well characterized model of an intact and a degraded surface of fibrin that represents the states of fibrin during the initiation and the progression of fibrinolysis was used to quantitatively characterize the molecular interplay between tissue-type plasminogen activator (t-PA), plasminogen and fibrin. The molecular assembly of t-PA and...
article 1993