Association between apolipoprotein E ε4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia

Objective: To determine whether the apolipoprotein E ε4 allele (apoE ε4) is associated with cognitive decline in individuals with and without dementia, we conducted a 4-year longitudinal study of subjects with a range of cognitive function Setting: At baseline, respondents (n = 511) were randomly selected according to age and Mini-Mental State...

Apolipoprotein e4 allele and cognitive decline in elderly men

Objectives - To determine whether polymorphism of apolipoprotein E - notably, the e4 allele - predicts cognitive deterioration in the general population. Design - Population based cohort investigated in 1990 and in 1993. Setting - Zutphen, the Netherlands. Subjects - Representative cohort of 538 Dutch men aged 70-89 at baseline. Main outcome...