Searched for: author%3A%22Lansbergen%2C+M.J.%22
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Willems, M.I. (author), de Raat, W.K. (author), Baan, R.A. (author), Wilmer, J.W.G.M. (author), Lansbergen, M.J. (author), Lohman, P.H.M. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The sensitivity of various methods suitable for biomonitoring the exposure to genotoxicants was compared in an animal model. The results were related to the presence of genotoxic effects in the target organ. Groups of male Wistar rats were given one oral dose of 0, 0.1, 1, 10 or 200 mg 2-acetylaminofluorene (2-AAF)/5 ml dimethyl sulphoxide/kg...
article 1987
Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author), Baan, R.A. (author), Lansbergen, M.J. (author), de Bruin, P.A.F. (author), Willems, M.I. (author), Lohman, P.H.M. (author)
Exposure of cells to chemical carcinogens and mutagens may result in the formation of DNA adducts, which can give rise to mutations in the genome and to cellular transformation. Methods to measure DNA-adduct formation may be useful for 'biomonitoring', to establish exposure of laboratory animals or humans to DNA-damaging agents. For such...
article 1985