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Maassen, C.B.M. (author), van Holten-Neelen, C. (author), Balk, F. (author), den Bak-Glashouwer, M.-J.H. (author), Leer, R.J. (author), Laman, J.D. (author), Boersma, W.J.A. (author), Claassen, E. (author)Different Lactobacillus strains are frequently used in consumer food products. In addition, recombinant lactobacilli which contain novel expression vectors can now be used in immunotherapeutic applications such as oral vaccination strategies and in T cell tolerance induction approaches for autoimmune disease. Both for food and clinical...article 2000
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TNO Preventie en Gezondheid (author), Huisman, J.G. (author), Carotenuto, A. (author), Labrijn, A.F. (author), Papavoine, C.H.M. (author), Laman, J.D. (author), Schellekens, M.M. (author), Koppelman, M.H.G.M. (author), Hilbers, C.W. (author)To identify structural constraints and amino acid sequences important for antibody recognition of the third variable domain (V3) of HIV-1 gp120, we have studied the solution conformation of three 35-mer circular V3 loop peptides derived from HIV-1 strains which differ in syncytium- (SI) and non-syncytium-inducing (NSI) capacity. In addition to...article 2000
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Maassen, C.B.M. (author), Laman, J.D. (author), Heijne den Bak-Glashouwer, M.J. (author), Tielen, F.J. (author), van Holten-Neelen, J.C.P.A. (author), Hoogteijling, L. (author), Antonissen, C. (author), Leer, R.J. (author), Pouwels, P.H. (author), Boersma, W.J.A. (author), Shaw, D.M. (author)Lactobacillus strains possess properties that make them attractive candidates as vehicles for oral administration of therapeutics. In this report we describe the construction and analysis of recombinant Lactobacillus casei applicable in oral vaccination against an infectious disease (tetanus) and in oral tolerance induction for intervention in...article 1999
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TNO Preventie en Gezondheid (author), Howard, L.M. (author), Miga, A.J. (author), Vanderlugt, C.L. (author), Dal Canto, M.C. (author), Laman, J.D. (author), Noelle, R.J. (author), Miller, S.D. (author)Relapsing experimental autoimmune encephalomyelitis (R-EAE) in the SJL mouse is a Th1-mediated autoimmune demyelinating disease model for human multiple sclerosis and is characterized by infiltration of the central nervous system (CNS) by Th1 cells and macrophages. Disease relapses are mediated by T cells specific for endogenous myelin epitopes...article 1999
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Laman, J.D. (author), de Boer, M. (author), 't Hart, B.A. (author), TNO Preventie en Gezondheid (author)The interactions of CD40 and CD40L have been known for some time to critically regulate B-cell responses with respect to proliferation, isotype switching, antibody production, and memory formation. More recent findings demonstrated that CD40 can be expressed on several other antigen-presenting cell (APC) types such as macrophages, dendritic...article 1998
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Laman, J.D. (author), Thompson, E.J. (author), Kappos, L. (author), TNO Preventie en Gezondheid (author)The need for reliable markers of disease activity in multiple sclerosis (MS) to better guide basic research, diagnosis, treatment, and monitoring of therapy is well-recognized. A recent European Charcot Foundation Symposium (Body fluid markers for course and activity of disease in multiple sclerosis (Madrid, Spain, October 2-4, 1997) organized...article 1998
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Laman, J.D. (author), Maassen, C.B.M. (author), Schellekens, M.M. (author), Visser, L. (author), Kap, M. (author), de Jong, E. (author), van Puijenbroek, M. (author), van Stipdonk, M.J.B. (author), van Meurs, M. (author), Schwärzler, C. (author), Günthert, U. (author), TNO Preventie en Gezondheid (author)Interactions between mononuclear cells are required for the formation of inflammatory infiltrates in the CNS and the activation of cellular effector functions provoking demyelination in MS. Membrane-expressed costimulatory molecules are crucial to such interactions. We therefore investigated whether two costimulatory molecules, CD40L (CD154,...article 1998
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- Laman, J.D. (author), Thompson, E.J. (author), Kappos, L. (author), TNO Preventie en Gezondheid (author) article 1998
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Vyth-Dreese, F.A. (author), Boot, H. (author), Dellemijn, T.A.M. (author), Majoor, D.M. (author), Oomen, L.C.J.M. (author), Laman, J.D. (author), van Meurs, M. (author), de Weger, R.A. (author), de Jong, D. (author), TNO Preventie en Gezondheid (author)Costimulatory molecules are essential in cognate interactions between T and B lymphocytes. To study the prerequisites of functional interactions between malignant B cells and intermingled T cells in B-cell non-Hodgkin's lymphomas (B-NHL), we examined the expression of CD40, CD80 and CD86 and their ligands CD40 ligand (CD40L, CD154), CD28 and...article 1998
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Laman, J.D. (author), van Meurs, M. (author), Schellekens, M.M. (author), de Boer, M. (author), Melchers, B. (author), Massacesi, L. (author), Lassmann, H. (author), Claassen, E. (author), 't Hart, B.A. (author), TNO Preventie en Gezondheid (author)Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the expression of selected...article 1998
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Maassen, C.B.M. (author), van Holten, J.C.A.M. (author), Balk, F. (author), Heijne den Bak-Glashouwer, M.J. (author), Leer, R. (author), Laman, J.D. (author), Boersma, W.J.A. (author), Claassen, E. (author), TNO Preventie en Gezondheid (author)In mice, strain dependent cytokine production profiles are induced after oral administration of Lactobacillus. Such a cytokine profile seems to determine the direction and efficacy of the humoral response. In SJL mice lactobacilli are able to enhance or inhibit the development of disease after induction of experimental autoimmune...article 1998
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Laman, J.D. (author), van Meurs, M. (author), de Smet, B.J.G.L. (author), Schoneveld, A. (author), TNO Preventie en Gezondheid (author)The abundant presence of macrophages and activated T cells in atherosclerotic plaques suggests an active involvement of the immune system in this cardiovascular disease. However, insight into cellular interactions inducing relevant effector functions is still limited. Here, Jon Laman and colleagues propose that local interactions between CD40...article 1997
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Laman, J.D. (author), Claassen, E. (author), Noelle, R.J. (author), TNO Preventie en Gezondheid (author)Initially, a role for the interaction between CD40, expressed on B cells, and gp39 (CD40L), expressed on activated T cells, has been defined in humoral immunity. CD40-CD40L interaction is an essential signal for B cell proliferation, expression of activation markers, immunoglobulin production, and isotype switching. CD40-CD40L interaction is...article 1996
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Gaubius Instituut TNO (author), Gerritse, K. (author), Laman, J.D. (author), Noelle, R.J. (author), Aruffo, A. (author), Ledbetter, J.A. (author), Boersma, W.J.A. (author), Claassen, E. (author)We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Activated helper T cells expressing CD40L (gp39) surface protein were found in MS patient brain sections, but not in brain tissue sections of normal controls or patients with other neurological diseases....article 1996
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Foy, T.M. (author), Laman, J.D. (author), Ledbetter, J.A. (author), Aruffo, A. (author), Claassen, E. (author), Noelle, R.J. (author), Medisch Biologisch Laboratorium TNO (author)gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the generation of antibody responses to T-dependent (TD) antigens. Treatment of mice with anti-gp39 in vivo inhibits both primary and secondary antibody formation to TD, but not T-independent antigens. However, the role of this receptor-ligand pair in the...article 1994
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van den Eertwegh, A.J.M. (author), Laman, J.D. (author), Schellekens, M.M. (author), Boersma, W.J.A. (author), Claassen, E. (author), Medisch Biologisch Laboratorium TNO (author)In this study we demonstrate a hitherto undescribed phenomenon, namely that thymus-independent type-2 antigens (TI-2 Ag) localize in splenic follicles within 1 h after administration. The follicular localization of 2,4,6-trinitrophenyl (TNP)-Ficoll was not antibody mediated. In addition in case of high-dose administration we observed a...article 1992
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- Laman, J.D. (author), van den Eertwegh, A.J.M. (author), Parmentier, H.K. (author), Schuurman, H.J. (author), Medisch Biologisch Laboratorium TNO (author) article 1992
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Laman, J.D. (author), ter Hart, H. (author), Boorsma, D.M. (author), Claassen, E. (author), van Rooijen, N. (author), Medisch Biologisch Laboratorium TNO (author)Studies concerning the localization of immune complexes in lymphoid follicles and the involvement of these trapped immune complexes in the regulation of the immune response have thus far been performed with poorly defined complexes in terms of size and composition. For that reason, the minimum requirements for trapping in terms of number of...article 1992
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- Claassen, E. (author), Gerritse, K. (author), Laman, J.D. (author), Boersma, W.J.A. (author), Medisch Biologisch Laboratorium TNO (author) article 1992
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Gaubius instituut TNO (author), Laman, J.D. (author)The aim of the studies presented in this thesis was to investigate the formation of epitope-specific antibody and the mechanisms involved in the localization of resulting antigen-antibody immune complexes in lymphoid follicles. These issues were addressed both in experimental animals and in clinical material. HIV-1 (human immunodeficiency virus...doctoral thesis 1992
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