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Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes

Price, R.J. (author), Scott, M.P. (author), Giddings, A.M. (author), Walters, D.G. (author), Stierum, R.H. (author), Meredith, C. (author), Lake, B.G. (author), TNO Kwaliteit van Leven (author)

1. The objective of this study was to investigate the effects of four food chemicals, namely butylated hydroxytoluene (BHT), curcumin (CC), propyl gallate (PG) and thiabendazole (TB), on cytochrome P450 (CYP) forms in cultured human hepatocytes. 2. Treatment of human hepatocytes for 72 h with 2-200 μM TB produced concentration-dependent...

article 2008

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Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole

Stierum, R. (author), Conesa, A. (author), Heijne, W. (author), Ommen, B.v. (author), Junker, K. (author), Scott, M.P. (author), Price, R.J. (author), Meredith, C. (author), Lake, B.G. (author), Groten, J. (author), TNO Kwaliteit van Leven (author), KvL (author)

Transcriptomics was performed to gain insight into mechanisms of food additives butylated hydroxytoluene (BHT), curcumin (CC), propyl gallate (PG), and thiabendazole (TB), additives for which interactions in the liver can not be excluded. Additives were administered in diets for 28 days to Sprague-Dawley rats and cDNA microarray experiments were...

article 2008

document

Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes

Price, R.J. (author), Scott, M.P. (author), Walters, D.G. (author), Stierum, R.H. (author), Groten, J.P. (author), Meredith, C. (author), Lake, B.G. (author), TNO Voeding (author)

The effect of thiabendazole (TB) on some rat hepatic xenobiotic metabolising enzymes has been investigated. Male Sprague-Dawley rats were fed control diet or diets containing 102-5188 ppm TB for 28 days. As a positive control for induction of hepatic xenobiotic metabolism, rats were also fed diets containing 1457 and 10,155 ppm butylated...

article 2004

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Studies on the disposition, metabolism and hepatotoxicity of coumarin in the rat and Syrian hamster

Lake, B.G. (author), Evans, J.G. (author), Chapuis, F. (author), Walters, D.G. (author), Price, R.J. (author), TNO Voeding (author)

article 2002

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Species differences in coumarin metabolism: A molecular modelling evaluation of CYP2A interactions

Lewis, D.F.V. (author), Lake, B.G. (author), TNO Voeding (author)

article 2002

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Dose-related effects of the peroxisome proliferator methylclofenapate in rat liver

Lake, B.G. (author), Rumsby, P.C. (author), Cunninghame, M.E. (author), Price, R.J. (author), TNO Voeding (author)

article 2002

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Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYPIA, CYP2B and CYP4A forms in precision-cut rat liver slices

Pan, J. (author), Xiang, Q. (author), Renwick, A.B. (author), Price, R.J. (author), Ball, S.E. (author), Kao, J. (author), Scatina, J.A. (author), Lake, B.G. (author), TNO Voeding (author)

article 2002

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Inhibition of zaleplon metabolism by cimetidine in the human liver: In vitro studies with subcellular fractions and precision-cut liver slices

Renwick, A.B. (author), Ball, S.E. (author), Tredger, J.M. (author), Price, R.J. (author), Walters, D.G. (author), Kao, J. (author), Scatina, J.A. (author), Lake, B.G. (author), TNO Voeding (author)

The effect of cimetidine on the metabolism of zaleplon (ZAL) in human liver subcellular fractions and precision-cut liver slices was investigated. 2. ZAL was metabolized to a number of products including 5-oxo-ZAL (M2), which is known to be formed by aldehyde oxidase, N-desethyl-ZAL (DZAL), which is known to be formed by CYP3A forms, and N...

article 2002

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Quantitative structure: Activity relationships for inducers of cytochromes P450 and nuclear receptor ligands involved in P450 regulation within the CYP1, CYP2, CYP3 and CYP4 families

Lewis, D.F.V. (author), Jacobs, M.N. (author), Dickins, M. (author), Lake, B.G. (author), TNO Voeding (author)

article 2002

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Metabolism of a novel phosphodiesterase-IV inhibitor (V11294) by human hepatic cytochrome P450 forms

Subrahmanyam, V. (author), Renwick, A.B. (author), Waters, D.G. (author), Price, R.J. (author), Tonelli, A.P. (author), Lake, B.G. (author), TNO Voeding (author)

article 2002

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Metabolism of zaleplon by human liver: Evidence for involvement of aldehyde oxidase

Lake, B.G. (author), Ball, S.E. (author), Kao, J. (author), Renwick, A.B. (author), Price, R.J. (author), Scatina, J.A. (author), TNO Voeding (author)

article 2002

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Molecular modelling of the peroxisome proliferator-activated receptor alpha (PPARalpha) from human, rat and mouse, based on homology with the human PPARypsilon crystal structure

Lewis, D.F.V. (author), Jacobs, M.N. (author), Dickins, M. (author), Lake, B.G. (author), TNO Voeding (author)

article 2002

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Lack of effect of furfural on unscheduled DNA synthesis in the in vivo rat and mouse hepatocyte DNA repair assays and in precision-cut human liver slices

Lake, B.G. (author), Edwards, A.J. (author), Price, R.J. (author), Phillips, B.J. (author), Renwick, A.B. (author), Beamand, J.A. (author), Adams, T.B. (author), TNO Voeding (author)

article 2001

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Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethyl- coumarin by human hepatic CYP isoforms: Evidence for selectivity towards CYP3A4

Renwick, A.B. (author), Lewis, D.F.V. (author), Fulfords, S. (author), Surry, D. (author), Williams, B. (author), Worboys, P.D. (author), Cai, X. (author), Wang, R.W. (author), Price, R.J. (author), Lake, B.G. (author), Evans, D.C. (author), TNO Voeding (author)

article 2001

document

Carbamazapine: A 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems

Pelkonen, O. (author), Myllynen, P. (author), Taavitsainen, P. (author), Boobis, A.R. (author), Watts, P. (author), Lake, B.G. (author), Price, R.J. (author), Renwick, A.B. (author), Gómez-Lechón, M.J. (author), Castell, J.V. (author), Ingelman-Sundberg, M. (author), Hidestrand, M. (author), Guillouzo, A. (author), Corcos, L. (author), Goldfarb, P.S. (author), Lewis, D.F.V. (author), TNO Voeding (author)

article 2001

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Evaluation of 7-benzyloxy-4-trifluoromethyl-coumarin, some other 7-hydroxy-4-trifluoro-methylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes

Renwick, A.B. (author), Lavignette, G. (author), Worboys, P.D. (author), Williams, B. (author), Surry, D. (author), Lewis, D.F.V. (author), Price, R.J. (author), Lake, B.G. (author), Evans, D.C. (author), TNO Voeding (author)

article 2001

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Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

Subrahmanyam, V. (author), Renwick, A.B. (author), Walters, D.G. (author), Young, P.J. (author), Price, R.J. (author), Tonelli, A.P. (author), Lake, B.G. (author), TNO Voeding (author)

article 2001

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An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant

Andersson, T.B. (author), Sjöberg, H. (author), Hoffmann, K.J. (author), Boobis, A.R. (author), Watts, P. (author), Edwards, R.J. (author), Lake, B.G. (author), Price, R.J. (author), Renwick, A.B. (author), Gómez-Lechón, M.J. (author), Castell, J.V. (author), Ingelman-Sundberg, M. (author), Hidestrand, M. (author), Goldfarb, P.S. (author), Lewis, D.F.V. (author), Corcos, L. (author), Guillouzo, A. (author), Taavitsainen, P. (author), Pelkonen, O. (author), TNO Voeding (author)

article 2001

document

Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms

Renwick, A.B. (author), Surry, D. (author), Price, R.J. (author), Lake, B.G. (author), Evans, D.C. (author)

article 2000

document

Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices

Renwick, A.B. (author), Watts, P.S. (author), Edwards, R.J. (author), Barton, P.T. (author), Guyonnet, I. (author), Price, R.J. (author), Tredger, J.M. (author), Pelkonen, O. (author), Boobis, A.R. (author), Lake, B.G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)

The maintenance of the major hepatic cytochrome P450 (CYP) enzymes has been studied in precision-cut human liver slices cultured for up to 72 h in supplemented RPMI 1640 medium. The relative apoprotein levels of 11 CYP enzymes were determined using a panel of antipeptide antibodes. In addition, 7-ethoxyresorufin O-deethylase, tolbutamide...

article 2000