Searched for: author%3A%22Lafeber%2C+F.P.J.G.%22
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Kozijn, A.E. (author), Tartjiono, M.T. (author), Ravipati, S. (author), van der Ham, F. (author), Barrett, D.A. (author), Mastbergen, S.C. (author), Korthagen, N.M. (author), Lafeber, F.P.J.G. (author), Zuurmond, A.M. (author), Bobeldijk, I. (author), Weinans, H. (author), Stoop, R. (author)
Objective. C-reactive protein (CRP) levels can be elevated in osteoarthritis (OA) patients. In addition to indicating systemic inflammation, it is suggested that CRP itself can play a role in OA development. Obesity and metabolic syndrome are important risk factors for OA and also induce elevated CRP levels. Here we evaluated in a human CRP ...
article 2019
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Kozijn, A.E. (author), Gierman, L.M. (author), van der Ham, F. (author), Mulder, P. (author), Morrison, M.C. (author), Kühnast, S. (author), van der Heijden, R.A. (author), Stavro, P.M. (author), van Koppen, A. (author), Pieterman, E.J. (author), van den Hoek, A.M. (author), Kleemann, R. (author), Princen, H.M.G. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author), Zuurmond, A.M. (author), Bobeldijk, I. (author), Weinans, H. (author), Stoop, R. (author)
Objective. Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation in the knees of mice from different genetic backgrounds in which a metabolic phenotype was...
article 2018
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Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...
article 2018
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de Visser, H.M. (author), Mastbergen, S.C. (author), Kozijn, A.E. (author), Coeleveld, K. (author), Pouran, B. (author), van Rijen, M.H. (author), Lafeber, F.P.J.G. (author), Weinans, H. (author)
Evidence is growing for the existence of an obesity-related phenotype of osteoarthritis in which low-grade inflammation and a disturbed metabolic profile play a role. The contribution of an obesity-induced metabolic dysbalance to the progression of the features of osteoarthritis upon mechanically induced cartilage damage was studied in a rat in...
article 2018
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Schoeman, J.C. (author), Harms, A.C. (author), van Wietmarschen, H.A. (author), Vreeken, R.J. (author), Berger, R. (author), Cuppen, B.V.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author), Hankemeier, T. (author)
Oxidised lipids, covering enzymatic and auto-oxidation-synthesised mediators, are important signalling metabolites in inflammation while also providing a readout for oxidative stress, both of which are prominent physiological processes in a plethora of diseases. Excretion of these metabolites via urine is enhanced through the phase-II...
article 2016
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Cuppen, B.V.J. (author), Fu, J. (author), van Wietmarschen, H.A. (author), Harms, A.C. (author), Koval, S. (author), Marijnissen, A.C.A. (author), Peeters, J.J.W. (author), Bijlsma, J.W.J. (author), Tekstra, J. (author), van Laar, J.M. (author), Hankemeier, T. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
In clinical practice, approximately one-Third of patients with rheumatoid arthritis(RA) respond insufficiently to TNF-alpha inhibitors (TNFis). The aim of the study was to explore the use of a metabolomics to identify predictors for the outcome of TNFi therapy, and study the metabolomic fingerprint in active RA irrespective of patients' response...
article 2016
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Vos, P.A.J.M. (author), Welsing, P.M.J. (author), de Groot, J. (author), Huisman, A.M. (author), Oostveen, J.C.M. (author), Reijman, M. (author), Damen, J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)
Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced glycation end products (AGEs). The present study evaluates whether pentosidine can predict radiographic progression and/or burden over 5 years follow-up in...
article 2013
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Vos, P.A.J.M. (author), Mastbergen, S.C. (author), Huisman, A.M. (author), de Boer, T.N. (author), de Groot, J. (author), Polak, A.A. (author), Lafeber, F.P.J.G. (author)
Objectives: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence...
article 2012
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Vos, P.A.J.M. (author), Degroot, J. (author), Barten-Van Rijbroek, A.D. (author), Zuurmond, A.-M. (author), Bijlsma, J.W.J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)
Osteoarthritis is a highly prevalent disease, age being the main risk factor. The age-related accumulation of advanced-glycation-endproducts (AGEs) adversely affects the mechanical and biochemical properties of cartilage. The hypothesis that accumulation of cartilage AGEs in combination with surgically induced damage predisposes to the...
article 2012
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van Spil, W.E. (author), Jansen, N.W.D. (author), Bijlsma, J.W.J. (author), Reijman, M. (author), de Groot, J. (author), Welsing, P.M.J. (author), Lafeber, F.P.J.G. (author)
Objective: To assess a wide spectrum of biochemical markers (biomarkers) in a large cohort of individuals with (very) early symptomatic knee and/or hip osteoarthritis (OA). Secondly, to investigate associations between biomarkers and between biomarkers and demographics to demonstrate validity of the obtained dataset and further investigate the...
article 2012
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Vos, P.A.J.M. (author), de Groot, J. (author), Huisman, A.M. (author), Oostveen, J.C.M. (author), Marijnissen, A.C.A. (author), Bijlsma, J.W.J. (author), van El, B. (author), Zuurmond, A.M. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Objectives: Age-related changes in articular cartilage are likely to play a role in the aetiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced-glycation-endproducts (AGEs). Since, cartilage tissue is not readily available from patients for studying AGE levels, alternative approaches...
article 2010
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van Spil, W.E. (author), de Groot, J. (author), Lems, W.F. (author), Oostveen, J.C.M. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Context: Molecules that are released into biological fluids during matrix metabolism of articular cartilage, subchondral bone, and synovial tissue could serve as biochemical markers of the process of osteoarthritis (OA). Unfortunately, actual breakthroughs in the biochemical OA marker field are limited so far. Objective: By reviewing the status...
article 2010
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Frost-Christensen, L.N. (author), Mastbergen, S.C. (author), Vianen, M.E. (author), Hartog, A. (author), de Groot, J. (author), Voorhout, G. (author), van Wees, A.M.C. (author), Lafeber, F.P.J.G. (author), Hazewinkel, H.A.W. (author), TNO Kwaliteit van Leven (author)
Objective: The most used model for joint instability is the canine anterior cruciate ligament transection (ACLT)-model. The ACLT-model can be extended with a medial meniscectomy (MX) (i.e., ACLT-MX-model) to avoid unintentional, and with that variable, meniscal damage. The present study compares the ACLT-MX-model with the more recently...
article 2008
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TNO Kwaliteit van Leven (author), Jansen, N.W.D. (author), Roosendaal, G. (author), Bijlsma, J.W.J. (author), de Groot, J. (author), Theobald, M. (author), Lafeber, F.P.J.G. (author)
Background: Joint bleeds have a direct adverse effect on joint cartilage, leading to joint deterioration and, ultimately, to disability. Objective: To examine the hypothesis that because degenerated cartilage has a limited repair capacity, it is more susceptible than healthy cartilage to blood-induced cartilage damage. Methods: Healthy,...
article 2008
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Jansen, N.W.D. (author), Roosendaal, G. (author), Bijlsma, J.W.J. (author), de Groot, J. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Objective. Joint bleeding, or hemarthrosis, leads in time to severe joint damage. This study was carried out to test the in vitro thresholds of exposure time and concentration that lead to irreversible joint damage, to add to the discussion on the usefulness of aspiration of the joint after a hemorrhage. Methods. Explants of healthy human...
article 2007
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Kamphorst, J.J. (author), van der Heijden, R. (author), de Groot, J. (author), Lafeber, F.P.J.G. (author), Reijmers, T.H. (author), van El, B. (author), Tjaden, U.R. (author), van der Greef, J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Synovial fluid potentially contains markers for early diagnosis and disease progression in degenerative joint diseases such as osteoarthritis. Here, a method is described for profiling endogenous peptides in human synovial fluid, using ultrafiltration, solid-phase extraction, nanoscale liquid chromatography, and high-resolution mass spectrometry...
article 2007
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TNO Kwaliteit van Leven (author), Steenvoorden, M.M.C. (author), Huizinga, T.W.J. (author), Verzijl, N. (author), Bank, R.A. (author), Ronday, H.K. (author), Luning, H.A.F. (author), Lafeber, F.P.J.G. (author), Toes, R.E.M. (author), de Groot, J. (author)
Objective. The major risk factor for osteoarthritis (OA) is aging, but the mechanisms underlying this risk are only partly understood. Age-related accumulation of advanced glycation end products (AGEs) could be one of these mechanisms. We undertook this study to investigate the role of the receptor for AGEs (RAGE) in mediating the cellular...
article 2006
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de Groot, J. (author), Verzijl, N. (author), van Wenting-Wijk, M.J.G. (author), Jacobs, K.M.G. (author), van El, B. (author), van Roermund, P.M. (author), Bank, R.A. (author), Bijlsma, J.W.J. (author), TeKoppele, J.M. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)
Objective. Osteoarthritis (OA) is one of the most prevalent and disabling chronic conditions affecting the elderly. Its etiology is largely unknown, but age is the most prominent risk factor. The current study was designed to test whether accumulation of advanced glycation end products (AGEs), which are known to adversely affect cartilage...
article 2004
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Bank, R.A. (author), Verzijl, N. (author), Lafeber, F.P.J.G. (author), Tekoppele, J.M. (author), Gaubius instituut TNO TNO Preventie en Gezondheid (author)
Objective: The collagen network in human articular cartilage experiences a large number of stress cycles during life as it shows hardly any turnover after adolescence. We hypothesized that, to withstand fatigue failure, the physical condition of the collagen network laid down at adolescence is of crucial importance for the age of onset of...
article 2002
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Verzijl, N. (author), de Groot, J. (author), Zaken, C.B. (author), Braun-Benjamin, O. (author), Maroudas, A. (author), Bank, R.A. (author), Mizrahi, J. (author), Schalkwijk, C.G. (author), Thorpe, S.R. (author), Baynes, J.W. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author), Gaubius Instituut TNO (author)
Objective. Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic glycation results in the accumulation of advanced glycation end products (AGEs) in cartilage collagen. We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage. Methods. To increase AGE levels,...
article 2002
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